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The map label for this gene is dtd [H]

Identifier: 218708191

GI number: 218708191

Start: 121228

End: 121662

Strand: Direct

Name: dtd [H]

Synonym: VS_0127

Alternate gene names: 218708191

Gene position: 121228-121662 (Clockwise)

Preceding gene: 218708190

Following gene: 218708192

Centisome position: 3.67

GC content: 47.13

Gene sequence:

>435_bases
GTGATAGCACTGATCCAGAGAGTAAGTGAAGCTGCCGTCCGTGTTGATGGCGAAGTAGTGGGTGAGATTGAGCAAGGCTT
ATTAGTTCTGTTAGGTGTAGAAAAAGGTGATGACGAAGCCAAAGCCAAACGTTTGATGGAACGAGTGACCACTTATCGTG
TCTTTGGAGATGAAGACGATAAAATGAACCTTAACGTGAAGCAGGTAGAAGGTAAGGTATTAGTGGTGTCTCAATTCACT
TTGCCAGCTGACACCAAGAAAGGGACACGAGCTGGATTTTCTCGCGGTGCTCACCCAGAAGATGCAGAGCGTCTTTACAA
CTACTTCTCTGACCAATGTGAATCAGTGTTGCCAACGGAACGTGGCCGATTCGCAGCCGACATGAAAGTGTCTTTGGTTA
ATGATGGCCCAGTGACATTCTGGCTGCAGGTTTAG

Upstream 100 bases:

>100_bases
GAAGTGACGGCCGCGTTGGGCGAGCAGGAACAGTGGAGTGACTCTCAAGAAATGGTACACTCGTCGGATAAAGACAAAAT
TACAGAGCAAGGAAACAACA

Downstream 100 bases:

>100_bases
GCTTAAAGGAATAAGCATGTTTAAACTCATAACCCCGACCACCGAAAATCAACTGAACAAGTATTACCATTTTCGTTGGC
AAATGCTCCGTGAACCTTGG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MIALIQRVSEAAVRVDGEVVGEIEQGLLVLLGVEKGDDEAKAKRLMERVTTYRVFGDEDDKMNLNVKQVEGKVLVVSQFT
LPADTKKGTRAGFSRGAHPEDAERLYNYFSDQCESVLPTERGRFAADMKVSLVNDGPVTFWLQV

Sequences:

>Translated_144_residues
MIALIQRVSEAAVRVDGEVVGEIEQGLLVLLGVEKGDDEAKAKRLMERVTTYRVFGDEDDKMNLNVKQVEGKVLVVSQFT
LPADTKKGTRAGFSRGAHPEDAERLYNYFSDQCESVLPTERGRFAADMKVSLVNDGPVTFWLQV
>Mature_144_residues
MIALIQRVSEAAVRVDGEVVGEIEQGLLVLLGVEKGDDEAKAKRLMERVTTYRVFGDEDDKMNLNVKQVEGKVLVVSQFT
LPADTKKGTRAGFSRGAHPEDAERLYNYFSDQCESVLPTERGRFAADMKVSLVNDGPVTFWLQV

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine [H]

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family [H]

Homologues:

Organism=Homo sapiens, GI30795227, Length=147, Percent_Identity=36.734693877551, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=67.5862068965517, Blast_Score=195, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI115533292, Length=143, Percent_Identity=38.4615384615385, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=39.8648648648649, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=36.986301369863, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003732 [H]

Pfam domain/function: PF02580 Tyr_Deacylase [H]

EC number: NA

Molecular weight: Translated: 16006; Mature: 16006

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALIQRVSEAAVRVDGEVVGEIEQGLLVLLGVEKGDDEAKAKRLMERVTTYRVFGDEDD
CHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEEECCCCC
KMNLNVKQVEGKVLVVSQFTLPADTKKGTRAGFSRGAHPEDAERLYNYFSDQCESVLPTE
CCCCEEEEECCEEEEEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RGRFAADMKVSLVNDGPVTFWLQV
CCCEEECEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MIALIQRVSEAAVRVDGEVVGEIEQGLLVLLGVEKGDDEAKAKRLMERVTTYRVFGDEDD
CHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEEECCCCC
KMNLNVKQVEGKVLVVSQFTLPADTKKGTRAGFSRGAHPEDAERLYNYFSDQCESVLPTE
CCCCEEEEECCEEEEEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RGRFAADMKVSLVNDGPVTFWLQV
CCCEEECEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]