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The map label for this gene is ilvC [H]

Identifier: 218708133

GI number: 218708133

Start: 51041

End: 52525

Strand: Direct

Name: ilvC [H]

Synonym: VS_0061

Alternate gene names: 218708133

Gene position: 51041-52525 (Clockwise)

Preceding gene: 218708131

Following gene: 218708138

Centisome position: 1.55

GC content: 46.13

Gene sequence:

>1485_bases
ATGGCTAACTATTTCAATACATTAAACCTTCGTGAGCAACTAGACCAATTAGGTCGCTGCCGTTTCATGGATCGTGAAGA
ATTTACGACTGAAGCTGAATACCTTGAAGGTAAGAAGATCGTCATTGTTGGCTGTGGTGCTCAAGGCCTGAACCAAGGTC
TAAACATGCGTGATTCTGGTCTAGACGTATCTTACGCTCTACGCCAAGCTGCAATTGATGAGAAGCGTCAATCATTCAAG
AATGCCGACGAAAACGGCTTTGTAGTTGGTAGCTACGAAACGCTAATCCCTCAAGCAGACCTAGTTATTAACCTTACTCC
CGACAAGCAACACACTAATGTTGTTGAGACAGTAATGCCTCTAATGAAAGAAGGCGCTGCTCTTGGTTACTCTCACGGCT
TTAACGTTGTGGAAGAAGGCATGCAATTACGAGCTGACCTTACTGTAGTAATGGTTGCACCTAAGTGTCCAGGTTCTGAA
GTTCGCGAAGAGTACAAGCGTGGCTTCGGTGTACCAACACTTATCGCTGTTCACCCAGAAAACGACCCTAAAGGTGAAGG
TTGGGATATCGCTAAAGCTTGGGCTGCAGGTACTGGTGGTCACCGTGCTGGTTGCCTAGAGTCTTCTTTCGTAGCAGAAG
TTAAATCTGACCTGATGGGTGAGCAAACAATCCTTTGTGGCATGCTACAAGCGGGTTCTATCGTATCTTACGAGAAGATG
ATTGCTGATGGTATCGAACCTGGCTACGCAGGCAAGCTTCTACAATACGGTTGGGAAACGATCACTGAAGCACTTAAGTT
TGGTGGCGTAACTCACATGATGGATCGCTTATCTAACCCAGCTAAAGTTAAAGCGTTTGAGCTTTCTGAAGAGCTTAAAG
ACCTAATGCGTCCGCTTTACAACAAGCACATGGATGACATCATCTCTGGTCACTTCTCTAGCACAATGATGGCTGACTGG
GCGAACGATGACGTGAACCTACTAGGCTGGCGTGAAGAGACAGGCGAAACTGCATTCGAAAACTACCCAGCTTCTGACGT
AGAAATCTCAGAGCAAGAGTACTTCGACAACGGTATCCTAATGGTTGCTATGGTTCGTGCCGGTGTTGAGCTAGCATTCG
AAGCTATGACGGCATCAGGCATCATTGATGAGTCTGCTTACTACGAATCTCTACATGAGCTTCCACTAATTGCAAACACA
GTTGCTCGTAAGCGTCTTTACGAAATGAACGTTGTAATCTCTGATACTGCTGAGTACGGTAACTACCTATTCGCTAACGT
AGCAACACCGCTACTACGTGAGAAGTTCATGCCTTCAGTAGCGACAGACGTAATCGGCCGTGGTCTAGGTGGAACATCTA
ACCAAGTTGATAACGCTAAGCTAATTGAAGTAAACGAAGCTATCCGTAACCACCCTGTAGAGTACATTGGTGAAGAGCTA
CGTAGCTACATGAGCGACATGAAGCGTATCGCTGTAGGCGGTTAA

Upstream 100 bases:

>100_bases
GAATATATCACTTTCAGCAACGGAGTGTCTGTTTTAGTATGAAGTCATTCGATAGAGAGATATCGACCTTACGGACTTAT
TTTTAAAGGAGTGCCCTACA

Downstream 100 bases:

>100_bases
TGAGTCTCTTAGATACTGACAAATTTGCAAAACAAGCGAAGCAGTATCATTAGCTCCTTACTGGTTGGAGTTATAAATAA
GCAACACAACATCTAATAGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MANYFNTLNLREQLDQLGRCRFMDREEFTTEAEYLEGKKIVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEKRQSFK
NADENGFVVGSYETLIPQADLVINLTPDKQHTNVVETVMPLMKEGAALGYSHGFNVVEEGMQLRADLTVVMVAPKCPGSE
VREEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVSYEKM
IADGIEPGYAGKLLQYGWETITEALKFGGVTHMMDRLSNPAKVKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDVNLLGWREETGETAFENYPASDVEISEQEYFDNGILMVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPSVATDVIGRGLGGTSNQVDNAKLIEVNEAIRNHPVEYIGEEL
RSYMSDMKRIAVGG

Sequences:

>Translated_494_residues
MANYFNTLNLREQLDQLGRCRFMDREEFTTEAEYLEGKKIVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEKRQSFK
NADENGFVVGSYETLIPQADLVINLTPDKQHTNVVETVMPLMKEGAALGYSHGFNVVEEGMQLRADLTVVMVAPKCPGSE
VREEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVSYEKM
IADGIEPGYAGKLLQYGWETITEALKFGGVTHMMDRLSNPAKVKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDVNLLGWREETGETAFENYPASDVEISEQEYFDNGILMVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPSVATDVIGRGLGGTSNQVDNAKLIEVNEAIRNHPVEYIGEEL
RSYMSDMKRIAVGG
>Mature_493_residues
ANYFNTLNLREQLDQLGRCRFMDREEFTTEAEYLEGKKIVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEKRQSFKN
ADENGFVVGSYETLIPQADLVINLTPDKQHTNVVETVMPLMKEGAALGYSHGFNVVEEGMQLRADLTVVMVAPKCPGSEV
REEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVSYEKMI
ADGIEPGYAGKLLQYGWETITEALKFGGVTHMMDRLSNPAKVKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWA
NDDVNLLGWREETGETAFENYPASDVEISEQEYFDNGILMVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTV
ARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPSVATDVIGRGLGGTSNQVDNAKLIEVNEAIRNHPVEYIGEELR
SYMSDMKRIAVGG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=494, Percent_Identity=73.8866396761134, Blast_Score=751, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=276, Percent_Identity=29.3478260869565, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54581; Mature: 54449

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLREQLDQLGRCRFMDREEFTTEAEYLEGKKIVIVGCGAQGLNQGLNMRDSG
CCCCHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDVSYALRQAAIDEKRQSFKNADENGFVVGSYETLIPQADLVINLTPDKQHTNVVETVMP
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKEGAALGYSHGFNVVEEGMQLRADLTVVMVAPKCPGSEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVSYEKM
CCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
IADGIEPGYAGKLLQYGWETITEALKFGGVTHMMDRLSNPAKVKAFELSEELKDLMRPLY
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDVNLLGWREETGETAFENYPASDVEISEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCHHHHCCCCCCCCCCHHHHHCCCHH
MVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVATPLLREKFMPSVATDVIGRGLGGTSNQVDNAKLIEVNEAIRNHPVEYIGEEL
CEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHH
RSYMSDMKRIAVGG
HHHHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLREQLDQLGRCRFMDREEFTTEAEYLEGKKIVIVGCGAQGLNQGLNMRDSG
CCCHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDVSYALRQAAIDEKRQSFKNADENGFVVGSYETLIPQADLVINLTPDKQHTNVVETVMP
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKEGAALGYSHGFNVVEEGMQLRADLTVVMVAPKCPGSEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVSYEKM
CCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
IADGIEPGYAGKLLQYGWETITEALKFGGVTHMMDRLSNPAKVKAFELSEELKDLMRPLY
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDVNLLGWREETGETAFENYPASDVEISEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCHHHHCCCCCCCCCCHHHHHCCCHH
MVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVATPLLREKFMPSVATDVIGRGLGGTSNQVDNAKLIEVNEAIRNHPVEYIGEEL
CEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHH
RSYMSDMKRIAVGG
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA