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The map label for this gene is uidB [H]

Identifier: 218705116

GI number: 218705116

Start: 1927667

End: 1929040

Strand: Reverse

Name: uidB [H]

Synonym: ECUMN_1905

Alternate gene names: 218705116

Gene position: 1929040-1927667 (Counterclockwise)

Preceding gene: 218705117

Following gene: 218705115

Centisome position: 37.08

GC content: 51.97

Gene sequence:

>1374_bases
ATGAATCAACAACTCTCCTGGCGCACCATCGTCGGCTACAGCCTCGGTGACGTCGCCAATAACTTCGCCTTCGCAATGGG
GGCGCTCTTCCTGTTGAGTTACTACACCGACGTCGCTGGCGTCGGTGCCGCTGCGGCGGGCACCATGCTGTTACTGGTGC
GGGTATTCGATGCCTTCGCCGACGTCTTTGCCGGACGAGTGGTGGACAGTGTGAATACCCGCTGGGGAAAATTCCGCCCG
TTTTTACTCTTCGGTACCGCGCCGTTAATGATCTTCAGCGTGCTGGTATTCTGGGCACCGACCGACTGGAGCCATAGCAG
CAAAGTAGTGTATGCATATTTGACCTACATGGGCCTCGGGCTTTGCTACAGCCTGGTGAATATTCCTTATGGTTCACTTG
CTACCGCAATGACCCAACAACCACAATCCCGCGCCCGTCTGGGCGCGGCTCGTGGGATTGCCGCTTCATTGACCTTTGTC
TGCCTGGCATTTCTGATAGGACCGAGCATTAAGAACTCTAGCCCGGAAGAGATGGTGTCGGTATACCATTTCTGGACGAT
TGTGCTGGCGATTGCCGGAATGGTGCTTTACTTCATCTGCTTCAAATCGACGCGTGAAAATGTGGTACGTATCGTGGCGC
AGCCGTCATTGAAGATCAGTCTGCAAACCCTGAAACGGAATCGCCCGCTGTTTATGTTGTGCATCGGTGCGCTGTGTGTG
CTGATTTCGACCTTCGCGGTCAGCGCCTCGTCGTTGTTCTACGTGCGCTATGTGTTAAATGATACCGGGCTGTTCACTGT
GCTGGTACTGGTGCAAAACCTGGTCGGTACTGTGGCATCGGCACCGCTGGTGCCGGGGATGGTCGCGAGGATCGGTAAAA
AGAATACCTTCCTGATTGGCGCTTTGCTGGGAAGCTGCGGTTATCTGCTGTTCTTCTGGGTTTCGGTCTGGTCACTGCCG
GTGGCGTTGGTTGCGTTGGCCATCGCTTCAATTGGTCAGGGCGTTACCATGACCGTGATGTGGGCACTGGAAGCTGATAC
TGTAGAATACGGTGAATACCTGACCGGCGTGCGAATAGAAGGGCTCACCTATTCACTATTCTCATTTACCCGTAAATGCG
GTCAGGCAATCGGAGGTTCAATTCCTGCCTTTATTTTGGGATTAAGCGGATATATTGCCAATCAGGTGCAAGCGCCGGAA
GTTATTATGGGCATCCGCACATCAATTGCCTTAGTACCTTGCGGATTTATGCTGCTGGCATTCGTCATTATCTGGTTTTA
TCCGCTCACGGATAAAAAATTCAAAGAAATCGTGGTTGAAATTGATAATCGTAAAAAAATGCAGCAGCAATTAATCCGCG
ATATCACTAATTAA

Upstream 100 bases:

>100_bases
TCTTCACCCGCGACCGCAAACCGAAGTCGGCGGCTTTTCTGCTGCAAAAACGCTGGACTGGCATGAACTTCGGTGAAAAA
CCGCAGCAGGGAGGCAAACA

Downstream 100 bases:

>100_bases
TATTCAATAAAAATAATCAGAACATCAAAGGTGCAACTATGAGAAAAATAGTGGCCATGGCCGTTATTTGCCTGACGGCT
GCCTCTGGCCTTACCTCTGC

Product: glucuronide transporter

Products: Proton [Cytoplasm]; Glucuronides [Cytoplasm] [C]

Alternate protein names: Glucuronide permease [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRP
FLLFGTAPLMIFSVLVFWAPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFV
CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGSCGYLLFFWVSVWSLP
VALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQAPE
VIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKMQQQLIRDITN

Sequences:

>Translated_457_residues
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRP
FLLFGTAPLMIFSVLVFWAPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFV
CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGSCGYLLFFWVSVWSLP
VALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQAPE
VIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKMQQQLIRDITN
>Mature_457_residues
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRP
FLLFGTAPLMIFSVLVFWAPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFV
CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGSCGYLLFFWVSVWSLP
VALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQAPE
VIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKMQQQLIRDITN

Specific function: Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by uidC (gusC, AC Q47706) [H]

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Escherichia coli, GI1787902, Length=457, Percent_Identity=98.2494529540481, Blast_Score=906, Evalue=0.0,
Organism=Escherichia coli, GI145693206, Length=453, Percent_Identity=33.112582781457, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI48994989, Length=457, Percent_Identity=32.8227571115974, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1786466, Length=460, Percent_Identity=31.304347826087, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI87082306, Length=456, Percent_Identity=28.2894736842105, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1790561, Length=461, Percent_Identity=27.5488069414317, Blast_Score=151, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49966; Mature: 49966

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00527 RIBOSOMAL_S14 ; PS00872 NA_GALACTOSIDE_SYMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; Glucuronides [Periplasm] [C]

Specific reaction: Proton [Periplasm] + Glucuronides [Periplasm] = Proton [Cytoplasm] + Glucuronides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3534890 [H]