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The map label for this gene is exuT [H]

Identifier: 218704240

GI number: 218704240

Start: 1037096

End: 1038403

Strand: Reverse

Name: exuT [H]

Synonym: ECUMN_1006

Alternate gene names: 218704240

Gene position: 1038403-1037096 (Counterclockwise)

Preceding gene: 218704241

Following gene: 218704239

Centisome position: 19.96

GC content: 53.75

Gene sequence:

>1308_bases
GTGCATATGAGTCAGGGTATCAATAACGATATGACTGCCAGTAAACCGCGCCATATCGTCAAAAATCTGCGTTGGTGGAT
ACTGGTCCTTTTTTTGCTCGGTGTTACTGTCAACTACATCACGCGTAACTCGCTGGGTATTCTCGCCCCCGAACTGAAAA
GCAACCTGGGGATTACCACCGAACAATATTCCTGGATTGTAGGTGCTTTCCAGCTCGCCTATACCCTATTCCAACCGTTG
TGTGGATGGCTGATTGACGTCATTGGCCTCAAACTGGGCTTTATGATCTGCGCGGGACTGTGGGCGCTGGCCTGTCTGAT
GCATGCGGGGGCGGGAAACTGGGTACATCTGGCGCTGTTGCGCTTCTTTATGGGCGGTGCGGAAGCCGCGGCAACCCCAG
CAAACGCCAAAACCATCGGTGAATGGTTTCCAAAATCAGAACGCCCGATCGCCGCAGGCTGGGCAGGCGTCGGTTTTTCC
ATCGGTGCCATGCTGGCCCCACCGATTATCTATTTTGCCCACGCTTCATTCGGCTGGCAGGGTGCATTTATGTTCACTGG
CATCCTGGCGATGCTGTGGGTGGTGCTGTGGTGGGCGTTCTATCACAACCCGGATAAGCATCCTAACCTCAGCAAAGCCG
AGCTGGACTTTATCCGCCAGGATAACGAAGCGCCCCCTGTCAAGTTACCCTTTCTGACCGCACTGAAAACCGTAGGCAAA
AATAAACGCTTTTACGGTATCGCTATCCCGGCCTTTATGGCAGAACCGGCGTGGGCGGTGATGAGTTTCTGGGTTCCGCT
ATACCTGTCCAAAACCTATGGCATGGACCTTAAGCAGATCGCATTATTCGCCTGGTTGCCGTTCCTCGCCGCTGATCTTG
GCAGTATTGCCAGCGGCTATCTGACCAAACTTTACACCCGCCTGTTTGGGCTGAGTCGTGTGAACTCCGTTGTCGCATCA
TCGGTCAGTGGCGCATTCCTGATGGTTTCGCTGGCGGTGATGGCCTTTACCAATAACCCGTATATCGCCATCGTCCTTAT
TTCCATCGGCGGCTTCGGTCACCAGATCATCTCCTGCATGCTGAGCGCACTGGTGGTGGAATCCTTCGACAAAGGTCAGA
TGGCCACTGTTAACGGCATGCGCGGTTCTGCCGCGTGGATCGCAAGTTTCCTGTTCTCCCTGATTATCGGGGTTACCGCT
GACAAAATCGGCTTTAACCCCCTGTTTATCGCCATGGGCTTCTTTGACCTGATTGGTGCTTTCTTCCTGGTCACCTTTAT
TGCTGAACGTCGCGCAAAACGCGCCTGA

Upstream 100 bases:

>100_bases
TGGAAAAACGAACAATAAAGACTTTATTTATCAAAAAGTTAAAAGTGGTGTGACAACTCCATTCTGACGTTGCCACACAA
ACCCTATACCATTCTGTGGA

Downstream 100 bases:

>100_bases
GAATGGATGTAAACATGAAAACGCTGAAAAACTGGACCCTGCACAAACAGTCTGCCCACCACGTTGAACTGCTGGTCGAT
GGCCAGCATATCCTGTGCCT

Product: putative hexuronate transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MHMSQGINNDMTASKPRHIVKNLRWWILVLFLLGVTVNYITRNSLGILAPELKSNLGITTEQYSWIVGAFQLAYTLFQPL
CGWLIDVIGLKLGFMICAGLWALACLMHAGAGNWVHLALLRFFMGGAEAAATPANAKTIGEWFPKSERPIAAGWAGVGFS
IGAMLAPPIIYFAHASFGWQGAFMFTGILAMLWVVLWWAFYHNPDKHPNLSKAELDFIRQDNEAPPVKLPFLTALKTVGK
NKRFYGIAIPAFMAEPAWAVMSFWVPLYLSKTYGMDLKQIALFAWLPFLAADLGSIASGYLTKLYTRLFGLSRVNSVVAS
SVSGAFLMVSLAVMAFTNNPYIAIVLISIGGFGHQIISCMLSALVVESFDKGQMATVNGMRGSAAWIASFLFSLIIGVTA
DKIGFNPLFIAMGFFDLIGAFFLVTFIAERRAKRA

Sequences:

>Translated_435_residues
MHMSQGINNDMTASKPRHIVKNLRWWILVLFLLGVTVNYITRNSLGILAPELKSNLGITTEQYSWIVGAFQLAYTLFQPL
CGWLIDVIGLKLGFMICAGLWALACLMHAGAGNWVHLALLRFFMGGAEAAATPANAKTIGEWFPKSERPIAAGWAGVGFS
IGAMLAPPIIYFAHASFGWQGAFMFTGILAMLWVVLWWAFYHNPDKHPNLSKAELDFIRQDNEAPPVKLPFLTALKTVGK
NKRFYGIAIPAFMAEPAWAVMSFWVPLYLSKTYGMDLKQIALFAWLPFLAADLGSIASGYLTKLYTRLFGLSRVNSVVAS
SVSGAFLMVSLAVMAFTNNPYIAIVLISIGGFGHQIISCMLSALVVESFDKGQMATVNGMRGSAAWIASFLFSLIIGVTA
DKIGFNPLFIAMGFFDLIGAFFLVTFIAERRAKRA
>Mature_435_residues
MHMSQGINNDMTASKPRHIVKNLRWWILVLFLLGVTVNYITRNSLGILAPELKSNLGITTEQYSWIVGAFQLAYTLFQPL
CGWLIDVIGLKLGFMICAGLWALACLMHAGAGNWVHLALLRFFMGGAEAAATPANAKTIGEWFPKSERPIAAGWAGVGFS
IGAMLAPPIIYFAHASFGWQGAFMFTGILAMLWVVLWWAFYHNPDKHPNLSKAELDFIRQDNEAPPVKLPFLTALKTVGK
NKRFYGIAIPAFMAEPAWAVMSFWVPLYLSKTYGMDLKQIALFAWLPFLAADLGSIASGYLTKLYTRLFGLSRVNSVVAS
SVSGAFLMVSLAVMAFTNNPYIAIVLISIGGFGHQIISCMLSALVVESFDKGQMATVNGMRGSAAWIASFLFSLIIGVTA
DKIGFNPLFIAMGFFDLIGAFFLVTFIAERRAKRA

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Escherichia coli, GI2367193, Length=430, Percent_Identity=42.5581395348837, Blast_Score=344, Evalue=5e-96,
Organism=Escherichia coli, GI87082320, Length=435, Percent_Identity=25.9770114942529, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789515, Length=366, Percent_Identity=26.775956284153, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1789152, Length=354, Percent_Identity=25.4237288135593, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI2367379, Length=384, Percent_Identity=23.9583333333333, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17532009, Length=294, Percent_Identity=22.4489795918367, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561498, Length=255, Percent_Identity=25.4901960784314, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573708, Length=302, Percent_Identity=25.1655629139073, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573707, Length=302, Percent_Identity=25.1655629139073, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573299, Length=299, Percent_Identity=23.0769230769231, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24658658, Length=435, Percent_Identity=22.7586206896552, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550495, Length=457, Percent_Identity=24.0700218818381, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24648416, Length=367, Percent_Identity=23.1607629427793, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356189, Length=367, Percent_Identity=23.1607629427793, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24639764, Length=335, Percent_Identity=21.4925373134328, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584153, Length=390, Percent_Identity=23.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24658666, Length=303, Percent_Identity=22.1122112211221, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45550460, Length=311, Percent_Identity=23.7942122186495, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24655255, Length=276, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641682, Length=365, Percent_Identity=23.013698630137, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47743; Mature: 47743

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]