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The map label for this gene is qacF [H]

Identifier: 218702462

GI number: 218702462

Start: 4389038

End: 4389373

Strand: Direct

Name: qacF [H]

Synonym: ECIAI39_4217

Alternate gene names: 218702462

Gene position: 4389038-4389373 (Clockwise)

Preceding gene: 218702461

Following gene: 218702465

Centisome position: 85.52

GC content: 40.18

Gene sequence:

>336_bases
TTGCTCATGTTTAATATTGGATTTTTATGGCTGGCACTTTCCATCGGTTCTGAAATAACCGGTACGTCAATGATCAAAAA
AACCAATGGTTTTAGGCGACTGTGGCCTTCTGTTCTGGTGGTATGTGCTTATTCAACGTGTTATTTCGCTCTGACCAGAG
CAATGAGTACTATTCCGGTTGGTGTTGCCTATTCACTCTGGTGCGGCTTTGGGATTGTTGGCGTGACAATTTTCTCGATG
ATTCTTTATAAACAAAAGCCCGATTTACCTGCCATATTCTCCATGTTGCTGATTATTAGTGGCGGCATTATTATGAATGT
ATTTTCAAACATGTAA

Upstream 100 bases:

>100_bases
TATTATCATTATGAATCTGTTCTCAAAAATGGGCAGTGAAGAGGCGGAAGAAACTCCAGTTACCAACCTCGATAAAAAAA
TCGCTAACTGACAAAAGGAA

Downstream 100 bases:

>100_bases
TGACCCCAAAAGTCTGCTTTCACGCACAATGCGGATCAGTTAAGGAGCAGTTGACCGGTCCTTAAACTGCGGCACTATAG
CGGCTTCCACAACAGGGAGC

Product: putative multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 111; Mature: 111

Protein sequence:

>111_residues
MLMFNIGFLWLALSIGSEITGTSMIKKTNGFRRLWPSVLVVCAYSTCYFALTRAMSTIPVGVAYSLWCGFGIVGVTIFSM
ILYKQKPDLPAIFSMLLIISGGIIMNVFSNM

Sequences:

>Translated_111_residues
MLMFNIGFLWLALSIGSEITGTSMIKKTNGFRRLWPSVLVVCAYSTCYFALTRAMSTIPVGVAYSLWCGFGIVGVTIFSM
ILYKQKPDLPAIFSMLLIISGGIIMNVFSNM
>Mature_111_residues
MLMFNIGFLWLALSIGSEITGTSMIKKTNGFRRLWPSVLVVCAYSTCYFALTRAMSTIPVGVAYSLWCGFGIVGVTIFSM
ILYKQKPDLPAIFSMLLIISGGIIMNVFSNM

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=103, Percent_Identity=38.8349514563107, Blast_Score=85, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12249; Mature: 12249

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
7.2 %Met     (Translated Protein)
9.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
9.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMFNIGFLWLALSIGSEITGTSMIKKTNGFRRLWPSVLVVCAYSTCYFALTRAMSTIPV
CEEEHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
GVAYSLWCGFGIVGVTIFSMILYKQKPDLPAIFSMLLIISGGIIMNVFSNM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MLMFNIGFLWLALSIGSEITGTSMIKKTNGFRRLWPSVLVVCAYSTCYFALTRAMSTIPV
CEEEHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
GVAYSLWCGFGIVGVTIFSMILYKQKPDLPAIFSMLLIISGGIIMNVFSNM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]