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The map label for this gene is acrE

Identifier: 218702038

GI number: 218702038

Start: 3928431

End: 3929588

Strand: Direct

Name: acrE

Synonym: ECIAI39_3765

Alternate gene names: 218702038

Gene position: 3928431-3929588 (Clockwise)

Preceding gene: 218702036

Following gene: 218702039

Centisome position: 76.55

GC content: 52.85

Gene sequence:

>1158_bases
ATGACGAAACATGCCAGGTTTTTCCTCCTGCCCTCCTTTATTCTGATCTCCGCGGCTTTAATCGCCGGTTGTAACGATAA
GGGAGAAGAGAAAGCTCACGTCGGTGAACCGCAGGTTACCGTTCATATTGTGAAAACGGCCCCGTTAGAAGTTAAGACTG
AATTACCAGGCCGCACCAATGCTTACCGTATAGCCGAAGTTCGCCCACAGGTTAGCGGGATCGTACTGAGTCGCAATTTC
ACTGAAGGCAGCGATGTGCAAGCAGGCCAGTCTCTGTACCAGATCGATCCCGCGACCTATCAGGCAAGTTATGACAGCGC
GAAAGGCGAACTGGCGAAAAGTGAAGCCGCCGCCGCCATCGCGCATTTGACGGTAAAACGTTACGTTCCGCTCGTGGGTA
CGAAATACATCAGTCAGCAGGAGTACGACCAGGCCATTGCTGATGCTCGCCAGGCCGATGCCGCCGTGATTGCCGCAAAA
GCCACAGTCGAAAGCGCTCGCATCAATCTCGCTTATACCAAAGTGACTGCGCCAATTAGCGGACGTATCGGCAAATCGAC
CGTGACCGAAGGCGCTCTTGTCACTAATGGGCAAACGACTGAACTGGCGACTGTCCAGCAGCTCGATCCTATCTACGTTG
ATGTGACCCAATCCAGCAACGATTTTATGAGGCTGAAGCAATCCGTAGAGCAAGGAAATTTGCATAAGGAAAACGCCACC
AGCAACGTAGAGTTGGTCATGGAGAACGGTCAAACCTATCCCCTGAAAGGTACGCTGCAATTCTCCGATGTGACCGTTGA
TGAAAGCACCGGCTCCATAACCCTACGTGCTGTCTTCCCTAACCCGCAACATACGCTTTTGCCGGGTATGTTTGTGCGCG
CACGGATTGATGAAGGCGTCCAACCTGACGCCATTCTTATCCCGCAACAAGGCGTTAGCCGCACACCACGTGGTGATGCA
ACCGTGCTGATTGTTAACGATAAAAGTCAGGTTGAAGCGCGCCCTGTCGTTGCCAGCCAGGCGATTGGCGATAAATGGTT
GATTAGCGAAGGGCTGAAATCTGGCGATCAAGTCATTGTCAGCGGCCTGCAAAAAGCGCGTCCGGGAGAGCAGGTTAAAG
CCACTACCGATACCCCCGCAGATTCTGCATCGAAGTAA

Upstream 100 bases:

>100_bases
ATGATAATTTGTAGGATAGCGAACTGTATTTTTCTTTCTGCGAGTTAACGCGTTGCCTTTTTGGGTAAATAACGCGCTTT
TGGTTTTTTGAGGAATAGTA

Downstream 100 bases:

>100_bases
GGCAATCTGACATGGCAAACTTTTTTATTCGACGACCGATATTTGCATGGGTGCTGGCCATTATTCTGATGATGGCGGGT
GTACTGGCGATCCTACAATT

Product: cytoplasmic membrane lipoprotein

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLSRNF
TEGSDVQAGQSLYQIDPATYQASYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAK
ATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDA
TVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADSASK

Sequences:

>Translated_385_residues
MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLSRNF
TEGSDVQAGQSLYQIDPATYQASYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAK
ATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDA
TVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADSASK
>Mature_384_residues
TKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLSRNFT
EGSDVQAGQSLYQIDPATYQASYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKA
TVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENATS
NVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDAT
VLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADSASK

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=385, Percent_Identity=99.2207792207792, Blast_Score=780, Evalue=0.0,
Organism=Escherichia coli, GI1786668, Length=375, Percent_Identity=69.3333333333333, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789929, Length=380, Percent_Identity=48.6842105263158, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=29.0625, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI87081796, Length=205, Percent_Identity=27.3170731707317, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87081951, Length=142, Percent_Identity=31.6901408450704, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41250; Mature: 41119

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTN
CCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCEEEEECCCCCCC
AYRIAEVRPQVSGIVLSRNFTEGSDVQAGQSLYQIDPATYQASYDSAKGELAKSEAAAAI
CEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
AHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPIS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEEEEEEEECCCC
GRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
CCCCCCCCCCCEEEECCCCCEEEHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGV
CCEEEEEECCCEECEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
QPDAILIPQQGVSRTPRGDATVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHCCCCHHHHH
SGLQKARPGEQVKATTDTPADSASK
HHHHHCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTN
CCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCEEEEECCCCCCC
AYRIAEVRPQVSGIVLSRNFTEGSDVQAGQSLYQIDPATYQASYDSAKGELAKSEAAAAI
CEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
AHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPIS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEEEEEEEECCCC
GRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
CCCCCCCCCCCEEEECCCCCEEEHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGV
CCEEEEEECCCEECEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
QPDAILIPQQGVSRTPRGDATVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHCCCCHHHHH
SGLQKARPGEQVKATTDTPADSASK
HHHHHCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]