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The map label for this gene is xdhB

Identifier: 218701576

GI number: 218701576

Start: 3429900

End: 3430778

Strand: Direct

Name: xdhB

Synonym: ECIAI39_3282

Alternate gene names: 218701576

Gene position: 3429900-3430778 (Clockwise)

Preceding gene: 218701575

Following gene: 218701577

Centisome position: 66.83

GC content: 53.47

Gene sequence:

>879_bases
ATGTTTGATTTTGCTTCTTACCATCGCGCAGCAACCCTTGCCGATGCCATCAAACTGCTGGCTGACAACCCGCAGGCCAA
ACTGCTCGCCGGTGGCACTGACGTACTGATTCAGCTCCACCATCACAATGACCGTTATCGCCATATTGTTGATATCCACA
ATCTGGCGGAGCTGCGGGGAATTACGCTGGCGGAAGATGGCTCAATACGTATCGGCTCTGCAACGACATTTACCCAGCTC
ATTGAAGATCCTGTAACTCAACGTCATCTCCCGGCGTTATGTGCTGCGGCCTCGTCCATTGCCGGACCGCAGATCCGTAA
CGTCGCTACCTACGGTGGAAATATTTGCAACGGTGCCACCAGCGCAGATTCTGCCACGCCAACGCTAATTTATGACGCAA
AGCTGGAGATCCACTCCCCACGCGGTGTTCGTTTCGTCCCGATTAATGGCTTTCACACTGGGCCAGGCAAAGTGTCTCTT
GAGCATGACGAAATCCTTGTCGCCTTTCATTTTCCGCCCCAGCCGAAAGAACACGCGGGCAGCGCGCATTTTAAATATGC
CATGCGCGACGCAATGGATATTTCAACGATTGGCTGCGCCGCACATTGCCGACTGGATAACGGCAATTTCAGCGAATTAC
GTCTGGCATTTGGTGTTGCCGCGCCAACGCCGATTCGCTGCCAACATGCCGAACAGACTGCACAAAATGCGCCATTAAAC
CTGCAAACGCTGGAAGCTATCAGCGAATCTGTCCTGCAAGATGTCGCCCCGCGTTCTTCATGGCGGGCCAGTAAAGAGTT
TCGTCTGCATCTCATCCAGACGATGACCAAAAAAGTGATTAGCGAAGCCGTCGCCGCGGCGGGGGGAAAATTGCAATGA

Upstream 100 bases:

>100_bases
GTGAAGATGGCTACCGGTGTTGCAATCAATACACTGCCGCTGACGCCAAAACGGTTATATGAAGAGTTCCATCTGGCAGG
ATTGATTTGAGGATAACATC

Downstream 100 bases:

>100_bases
ATCACAGCGAAACAATTACCATCGAATGCACCATTAACGGGATGCCTTTTCAGCTTCACGCCGCACCAGGCACGCCGCTC
TCGGAATTACTCCGCGAACA

Product: xanthine dehydrogenase subunit XdhB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFDFASYHRAATLADAIKLLADNPQAKLLAGGTDVLIQLHHHNDRYRHIVDIHNLAELRGITLAEDGSIRIGSATTFTQL
IEDPVTQRHLPALCAAASSIAGPQIRNVATYGGNICNGATSADSATPTLIYDAKLEIHSPRGVRFVPINGFHTGPGKVSL
EHDEILVAFHFPPQPKEHAGSAHFKYAMRDAMDISTIGCAAHCRLDNGNFSELRLAFGVAAPTPIRCQHAEQTAQNAPLN
LQTLEAISESVLQDVAPRSSWRASKEFRLHLIQTMTKKVISEAVAAAGGKLQ

Sequences:

>Translated_292_residues
MFDFASYHRAATLADAIKLLADNPQAKLLAGGTDVLIQLHHHNDRYRHIVDIHNLAELRGITLAEDGSIRIGSATTFTQL
IEDPVTQRHLPALCAAASSIAGPQIRNVATYGGNICNGATSADSATPTLIYDAKLEIHSPRGVRFVPINGFHTGPGKVSL
EHDEILVAFHFPPQPKEHAGSAHFKYAMRDAMDISTIGCAAHCRLDNGNFSELRLAFGVAAPTPIRCQHAEQTAQNAPLN
LQTLEAISESVLQDVAPRSSWRASKEFRLHLIQTMTKKVISEAVAAAGGKLQ
>Mature_292_residues
MFDFASYHRAATLADAIKLLADNPQAKLLAGGTDVLIQLHHHNDRYRHIVDIHNLAELRGITLAEDGSIRIGSATTFTQL
IEDPVTQRHLPALCAAASSIAGPQIRNVATYGGNICNGATSADSATPTLIYDAKLEIHSPRGVRFVPINGFHTGPGKVSL
EHDEILVAFHFPPQPKEHAGSAHFKYAMRDAMDISTIGCAAHCRLDNGNFSELRLAFGVAAPTPIRCQHAEQTAQNAPLN
LQTLEAISESVLQDVAPRSSWRASKEFRLHLIQTMTKKVISEAVAAAGGKLQ

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1319

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789231, Length=292, Percent_Identity=98.6301369863014, Blast_Score=597, Evalue=1e-172,
Organism=Drosophila melanogaster, GI17737937, Length=273, Percent_Identity=27.1062271062271, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 31543; Mature: 31543

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDFASYHRAATLADAIKLLADNPQAKLLAGGTDVLIQLHHHNDRYRHIVDIHNLAELRG
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCCHHEEHHHHHHHHHCC
ITLAEDGSIRIGSATTFTQLIEDPVTQRHLPALCAAASSIAGPQIRNVATYGGNICNGAT
CEEECCCCEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
SADSATPTLIYDAKLEIHSPRGVRFVPINGFHTGPGKVSLEHDEILVAFHFPPQPKEHAG
CCCCCCCEEEEEEEEEEECCCCEEEEEECCEECCCCCEEEECCCEEEEEECCCCCHHHCC
SAHFKYAMRDAMDISTIGCAAHCRLDNGNFSELRLAFGVAAPTPIRCQHAEQTAQNAPLN
CHHHHHHHHHHCCHHHCCEEEEEEECCCCHHHEEEEEECCCCCCCEECCHHHHHHCCCCC
LQTLEAISESVLQDVAPRSSWRASKEFRLHLIQTMTKKVISEAVAAAGGKLQ
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFDFASYHRAATLADAIKLLADNPQAKLLAGGTDVLIQLHHHNDRYRHIVDIHNLAELRG
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCCHHEEHHHHHHHHHCC
ITLAEDGSIRIGSATTFTQLIEDPVTQRHLPALCAAASSIAGPQIRNVATYGGNICNGAT
CEEECCCCEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
SADSATPTLIYDAKLEIHSPRGVRFVPINGFHTGPGKVSLEHDEILVAFHFPPQPKEHAG
CCCCCCCEEEEEEEEEEECCCCEEEEEECCEECCCCCEEEECCCEEEEEECCCCCHHHCC
SAHFKYAMRDAMDISTIGCAAHCRLDNGNFSELRLAFGVAAPTPIRCQHAEQTAQNAPLN
CHHHHHHHHHHCCHHHCCEEEEEEECCCCHHHEEEEEECCCCCCCEECCHHHHHHCCCCC
LQTLEAISESVLQDVAPRSSWRASKEFRLHLIQTMTKKVISEAVAAAGGKLQ
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]