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The map label for this gene is xdhA

Identifier: 218701575

GI number: 218701575

Start: 3427631

End: 3429889

Strand: Direct

Name: xdhA

Synonym: ECIAI39_3281

Alternate gene names: 218701575

Gene position: 3427631-3429889 (Clockwise)

Preceding gene: 218701569

Following gene: 218701576

Centisome position: 66.79

GC content: 52.77

Gene sequence:

>2259_bases
ATGCGCGTAGATGCCATTGCTAAGGTCACCGGGCGGGCACGATATACTGACGATTATGTTATGGCGGGCATGTGTTACGC
GAAATATGTACGTAGCCCTATCGCACATGGTTATGCCGTAAGTATTAATGATGAACAAGCCAGAAGTTTACCGGGCGTAC
TAGCGATTTTTACCTGGGAAGATGTGCCTGATATCCCATTCGCTACAGCTGGGCATGCCTGGACACTTGACGAAAACAAG
CGCGATACCGCCGATCGCGCACTGCTAACTCGCCATGTTCGTCACCATGGTGACGCCGTTGCCATCGTCGTGGCCCGTGA
TGAACTCACGGCAGAAAAAGCGGCGCAATTGGTCAGCATTGAGTGGCAAGAATTACCCGTTATCACCACCCCAGAAGCGG
CGCTGGCTGATGACGCTGAACCAATCCATAACGGCGGCAATTTACTAAAACAAAGCACTATGTCGACGGGCAATGTCCAA
CAAACAATCGATGCCGCCGACTACCAGGTTCAGGGGCACTATCAGACTCCCGTTATTCAACATTGTCACATGGAAAGCGT
GACATCGCTGGCATGGATGGAGGATGACTCGCGAATTACCATCGTTTCCAGCACCCAGATCCCGCACATTGTTCGCCGCG
TGGTTGGTCAGGCGCTGGATATTCCCTGGTCATGCGTACGAGTCATCAAACCGTTTGTCGGTGGCGGTTTTGGTAATAAA
CAGGATGTACTGGAAGAGCCAATGGCGGCATTCCTGACCAGCAAGCTTGGCGGCATTCCGGTGAAAGTTTCCCTTAGCCG
TGAAGAGTGTTTCCTCGCAACCCGTACCCGCCACGCTTTTACTATTGACGGGAAAATGGGCGTGAACCGCGACGGAACAT
TGAAAGGTTATAGTCTGGATGTTCTGTCTAACACCGGCGCTTACGCATCTCACGGGCACTCCATTGCTTCTGCTGGGGGG
AATAAAGTCGCTTACCTTTATCCTCGTTGTGCCTACGCTTACAGTTCAAAGACCTGCTATACCAACCTCCCCTCGGCTGG
TGCGATGCGTGGTTATGGCGCGCCACAAGTCGTATTTGCCGTTGAGTCTATGCTTGATGATGCCGCGACAGCGTTAGGTA
TTGATCCTGTTGAAATTCGTTTACGCAACGCCGCCCGCGAAGGAGATGCTAATCCGCTCACGGGCAAACGTATTTACAGC
GCAGGGTTGCCGGAGTGTCTTGAAAAAGGCCGGAAAATCTTTGAATGGGAAAAACGCCGTGCAGAGTGCCAGAACCAGAA
AGGCAATTTACGCCGCGGCGTTGGCGTCGCCTGTTTTAGCTACACCTCGAACACCTGGCCTGTCGGCGTAGAAATAGCAG
GCGCGCGCCTTCTGATGAATCAGGATGGAACCATCAACGTGCAAAGCGGCGCGACGGAAATCGGTCAGGGTGCCGACACC
GTCTTCTCGCAAATGGTGGCAGAAACCGTGGGGGTTCCGGTCAGCGACGTTCGCGTTATTTCAACACAAGATACCGATGT
TACGCCGTTCGATCCCGGCGCATTTGCCTCACGCCAGAGCTATGTTGCCGCGCCTGCGCTGCGCAGTGCGGCACTGTTAT
TAAAAGAGAAAATCATCGCTCACGCCGCAGTCATGCTACATCAGTCAGCGATGAATCTGACCCTGATAAAAGGCCATATC
GTGCTGATTGAACGACCGGAAGAACCGTTAATGTCGTTAAAAGATTTGGCGATGGACGCTTTCTACCACCCTGAACGCGG
CGGGCAGCTCTCTGCTGAAAGCTCCATCAAAACCACCACTAACCCACCGGCGTTCGGCTGTACCTTTGTTGATCTGACGG
TCGATATTGCACTGTGCAAAGTCACCATCAACCGCATCCTCAACGTTCATGATTCGGGGCATATTCTAAATCCGCTGCTG
GCAGAAGGTCAGGTACACGGCGGAATGGGAATGGGCATTGGCTGGGCGCTATTTGAAGAGATGATCATCGATGCGAAAAG
CGGCGTGGTCCGTAACCCCAATCTGCTGGATTACAAAATGCCGACCATGCCGGATCTGCCACAACTGGAAAGCGCGTTCG
TCGAAATCAATGAGCCGCAATCCGCATACGGACATAAGTCACTGGGTGAGCCACCAATAATTCCTGTTGCCGCTGCTATT
CGTAACGCGGTGAAGATGGCTACCGGTGTTGCAATCAATACACTGCCGCTGACGCCAAAACGGTTATATGAAGAGTTCCA
TCTGGCAGGATTGATTTGA

Upstream 100 bases:

>100_bases
CTTGCCTGCTTAGACTAAATCTTTGCCATAAGAACCAAATGTTCAAATCGAGGGGATTTCTATGGAAGCGCGGGAAGCAA
CCGCTACAGGTGAATCATGC

Downstream 100 bases:

>100_bases
GGATAACATCATGTTTGATTTTGCTTCTTACCATCGCGCAGCAACCCTTGCCGATGCCATCAAACTGCTGGCTGACAACC
CGCAGGCCAAACTGCTCGCC

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPFATAGHAWTLDENK
RDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALADDAEPIHNGGNLLKQSTMSTGNVQ
QTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGKMGVNRDGTLKGYSLDVLSNTGAYASHGHSIASAGG
NKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYS
AGLPECLEKGRKIFEWEKRRAECQNQKGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHI
VLIERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLL
AEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Sequences:

>Translated_752_residues
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPFATAGHAWTLDENK
RDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALADDAEPIHNGGNLLKQSTMSTGNVQ
QTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGKMGVNRDGTLKGYSLDVLSNTGAYASHGHSIASAGG
NKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYS
AGLPECLEKGRKIFEWEKRRAECQNQKGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHI
VLIERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLL
AEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
>Mature_752_residues
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPFATAGHAWTLDENK
RDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALADDAEPIHNGGNLLKQSTMSTGNVQ
QTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGKMGVNRDGTLKGYSLDVLSNTGAYASHGHSIASAGG
NKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYS
AGLPECLEKGRKIFEWEKRRAECQNQKGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHI
VLIERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLL
AEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=783, Percent_Identity=26.6922094508301, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI91823271, Length=764, Percent_Identity=25, Blast_Score=171, Evalue=3e-42,
Organism=Escherichia coli, GI1789230, Length=752, Percent_Identity=99.3351063829787, Blast_Score=1551, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=793, Percent_Identity=29.8865069356873, Blast_Score=309, Evalue=4e-85,
Organism=Escherichia coli, GI1786478, Length=763, Percent_Identity=29.2267365661861, Blast_Score=226, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17540638, Length=766, Percent_Identity=26.7624020887728, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17539860, Length=734, Percent_Identity=23.7057220708447, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32566215, Length=734, Percent_Identity=23.5694822888283, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17737937, Length=743, Percent_Identity=26.1103633916555, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24647193, Length=769, Percent_Identity=24.1872561768531, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24647199, Length=747, Percent_Identity=23.8286479250335, Blast_Score=136, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24647201, Length=746, Percent_Identity=23.1903485254692, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647195, Length=713, Percent_Identity=21.0378681626928, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24647197, Length=709, Percent_Identity=21.1565585331453, Blast_Score=97, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 81380; Mature: 81380

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWE
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEEEEEEEC
DVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSI
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHCHHHHHHEEEE
EWQELPVITTPEAALADDAEPIHNGGNLLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQ
EHHHCCEEECCCHHHCCCCCHHHCCCHHHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHH
HCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
HHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCH
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGKMGVNRDGTLKGYSLD
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEEE
VLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFA
EECCCCCCCCCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCCCCCCCCCCHHHHH
VESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECLEKGRKIFEWEKRR
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
AECQNQKGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
HHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEECCCCCHHCCCHHH
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIA
HHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HAAVMLHQSAMNLTLIKGHIVLIERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTT
HHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEE
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
MIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
HHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCCCCCCCCHHHHHHH
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
HHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWE
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEEEEEEEC
DVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSI
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHCHHHHHHEEEE
EWQELPVITTPEAALADDAEPIHNGGNLLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQ
EHHHCCEEECCCHHHCCCCCHHHCCCHHHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHH
HCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
HHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCH
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGKMGVNRDGTLKGYSLD
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEEE
VLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFA
EECCCCCCCCCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCCCCCCCCCCHHHHH
VESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECLEKGRKIFEWEKRR
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
AECQNQKGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
HHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEECCCCCHHCCCHHH
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIA
HHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HAAVMLHQSAMNLTLIKGHIVLIERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTT
HHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEE
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
MIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
HHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCCCCCCCCHHHHHHH
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
HHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]