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The map label for this gene is kdpE

Identifier: 218699050

GI number: 218699050

Start: 690196

End: 690873

Strand: Reverse

Name: kdpE

Synonym: ECIAI39_0653

Alternate gene names: 218699050

Gene position: 690873-690196 (Counterclockwise)

Preceding gene: 218699051

Following gene: 218699048

Centisome position: 13.46

GC content: 57.52

Gene sequence:

>678_bases
GTGACAAACGTTCTGATTGTTGAAGATGAACAGGCTATTCGTCGCTTTCTGCGCACGGCGCTGGAGGGCGACGGGATGCG
CGTCTTTGAGGCCGAAACGCTGCAACGCGGCTTGCTGGAAGCGGCAACCCGTAAGCCAGATTTGATTATTCTCGATCTCG
GCCTGCCCGATGGTGATGGGATTGAGTTTATCCGCGACCTGCGCCAGTGGAGCGCGGTGCCGGTGATTGTGCTTTCCGCA
CGCAGCGAAGAGAGCGACAAAATCGCCGCGCTGGATGCCGGAGCGGATGATTACCTGAGTAAGCCGTTTGGCATTGGCGA
ATTGCAGGCCCGTCTGCGCGTCGCTTTACGCCGCCACTCCGCCACCACCGCGCCCGATCCGCTGGTGAAATTTTCCGATG
TGACCGTCGATTTAGCCGCCCGCGTGATCCATCGCGGTGAGGAAGAGGTGCATCTCACCCCGATTGAGTTTCGCCTGCTG
GCGGTGCTGCTCAACAATGCCGGAAAAGTGCTCACCCAGCGCCAGCTCCTTAACCAGGTGTGGGGGCCAAACGCGGTCGA
ACACAGCCATTATTTGCGTATTTATATGGGACATCTGCGACAAAAACTGGAACAGGATCCCGCTCGCCCCCGCCATTTCA
TTACTGAAACCGGTATTGGGTATCGGTTTATGCTTTGA

Upstream 100 bases:

>100_bases
GCACCATTACCGCATTCAACCGACCGGAAGGTGGTGCCTGTTTTCGTGTTACACTTCCCCAGCAAACAGCCCCTGAACTT
GAAGAATTTCATGAGGATAT

Downstream 100 bases:

>100_bases
ATATTAATTTTAATACATCCTGCCTTTTATTAATTAAAGCCGTAATAATAAATACGGCTTTTTATCTTAAACAACACACA
AAAATAACAATTCAATATTT

Product: DNA-binding transcriptional activator KdpE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAVPVIVLSA
RSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLL
AVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML

Sequences:

>Translated_225_residues
MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAVPVIVLSA
RSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLL
AVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML
>Mature_224_residues
TNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAVPVIVLSAR
SEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLA
VLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=100, Blast_Score=453, Evalue=1e-129,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=36.7713004484305, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=35.2678571428571, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.7713004484305, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=35.5855855855856, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=35.4545454545455, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=31.981981981982, Blast_Score=116, Evalue=9e-28,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.2727272727273, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.8777292576419, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=33.6363636363636, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.9559471365639, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=31.140350877193, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.9661016949153, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=33.8842975206612, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=30.8823529411765, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1790437, Length=131, Percent_Identity=30.5343511450382, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDPE_ECOLI (P21866)

Other databases:

- EMBL:   M36066
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   E64804
- RefSeq:   AP_001332.1
- RefSeq:   NP_415222.1
- PDB:   1ZH2
- PDB:   1ZH4
- PDBsum:   1ZH2
- PDBsum:   1ZH4
- ProteinModelPortal:   P21866
- SMR:   P21866
- DIP:   DIP-10063N
- STRING:   P21866
- EnsemblBacteria:   EBESCT00000000310
- EnsemblBacteria:   EBESCT00000016264
- GeneID:   945302
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5096
- KEGG:   eco:b0694
- EchoBASE:   EB0512
- EcoGene:   EG10517
- eggNOG:   COG0745
- GeneTree:   EBGT00050000008651
- HOGENOM:   HBG753323
- OMA:   LEGEGCR
- ProtClustDB:   PRK10529
- BioCyc:   EcoCyc:KDPE-MONOMER
- Genevestigator:   P21866
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 25363; Mature: 25231

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDG
CCCEEEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
IEFIRDLRQWSAVPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHS
HHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHCC
ATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQV
CCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHHH
WGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEECC
>Mature Secondary Structure 
TNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDG
CCEEEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
IEFIRDLRQWSAVPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHS
HHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHCC
ATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQV
CCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHHH
WGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503