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The map label for this gene is gmhB

Identifier: 218698847

GI number: 218698847

Start: 482861

End: 483433

Strand: Reverse

Name: gmhB

Synonym: ECIAI39_0443

Alternate gene names: 218698847

Gene position: 483433-482861 (Counterclockwise)

Preceding gene: 218698854

Following gene: 218698846

Centisome position: 9.42

GC content: 50.96

Gene sequence:

>573_bases
GTGGCGAAGAGCGTACCCGCAATTTTTCTTGACCGTGATGGCACCATTAATGTCGATCACGGCTATGTCCATGAGATCGA
CAACTTTGAATTTATCGACGGTGTTATTGACGCCATGCGCGAGCTAAAAAAAATGGGCTTTGCGCTGGTGGTAGTAACCA
ACCAGTCTGGCATTGCTCGCGGTAAATTTACTGAAGCACAGTTTGAAACGCTGACCGAGTGGATGGACTGGTCGCTGGCG
GACCGCGATGTCGATCTGGATGGTATCTATTATTGCCCGCATCATCCGCAGGGGAGTGTTGAAGAGTTTCGCCAGGTCTG
CGACTGCCGCAAACCACATCCGGGGATGCTTTTATCGGCACGCGATTATTTGCATATTGATATGGCCGCTTCTTATATGG
TGGGCGATAAATTAGAAGATATGCAGGCAGCGGCTGCGGCGAACGTGGGAACAAAAGTGCTGGTGCGTACGGGTAAACCT
GTTACGCCTGAAGCAGAAAACGCGGCGGATTGGGTGTTAAATAGCCTGGCAGACCTGCCGCAAGCGATAAAAAAGCAGCA
AAAACCGGCGTAA

Upstream 100 bases:

>100_bases
TCCAGACGTCTAAATCAATCAGGTTTATGCGAAGAGCACTTTCTTGCAGGTCGAAACATGCGATACTAGCGTCACATGCC
TTATTAAGGAGCTATAAAAG

Downstream 100 bases:

>100_bases
TGATTAAAAGATGAGCGGTTGAAATAAAAATGCATTTTTCCGCTTGTCTTCCTGAGCCGACTCCCTATAATGCGCCTCCA
TCGACACGGCGGATGTGAAT

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLA
DRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKP
VTPEAENAADWVLNSLADLPQAIKKQQKPA

Sequences:

>Translated_190_residues
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLA
DRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKP
VTPEAENAADWVLNSLADLPQAIKKQQKPA
>Mature_189_residues
AKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLAD
RDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKPV
TPEAENAADWVLNSLADLPQAIKKQQKPA

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=190, Percent_Identity=98.9473684210526, Blast_Score=396, Evalue=1e-112,
Organism=Escherichia coli, GI87082027, Length=149, Percent_Identity=31.5436241610738, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- InterPro:   IPR013954 [H]

Pfam domain/function: PF08645 PNK3P [H]

EC number: 3.1.1.-

Molecular weight: Translated: 21124; Mature: 20993

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIAR
CCCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
GKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEC
RDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKPVTPEAENAADWVLNSLADLP
CCEEEEEHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QAIKKQQKPA
HHHHHHCCCC
>Mature Secondary Structure 
AKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIAR
CCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
GKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEC
RDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKPVTPEAENAADWVLNSLADLP
CCEEEEEHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QAIKKQQKPA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11108008; 11206551; 11258796 [H]