Click here to switch to the map view.

The map label for this gene is neuA [H]

Identifier: 218695661

GI number: 218695661

Start: 2339056

End: 2340321

Strand: Reverse

Name: neuA [H]

Synonym: EC55989_2294

Alternate gene names: 218695661

Gene position: 2340321-2339056 (Counterclockwise)

Preceding gene: 218695662

Following gene: 218695660

Centisome position: 45.4

GC content: 32.07

Gene sequence:

>1266_bases
ATGACTAATAGGATAGCGATAATTCCGGCTAGAGCGGGATCAAAAGGGTTACCAAATAAAAATGTTTTAATGTTAATAGA
TAAACCTCTTATAGCTTATACTATAGAGGCGGCAAAAGAATCGCAGTGCTTTAATAAAATTATTGTTTCAACAGATTCAT
TAGAATACAAAAGTATCGCTGAGAGATACGGTGCAGAAGTTATTATTAGAAGTGAAGAGCTTGCATCAGATACTGCAACT
ACATATATGGTTATAGAGAATGTATTGAGTCACAATAAAGATTGTGACTATTTTATGTTATTACAACCGACGTCTCCTTT
TAGAAATGCCCATCATATAAAGGAAGCCATTACGCTTTTTGAGGGGGATGTTGAAGCCAATTTTTTAGTTTCAATGACAG
AAAGCGAAATATCCTCAGATTTAATGAAAACTTTAGATTCCTCAATGCGACTGAGTAATTTCAATAATGACTACAGTGGC
TATAGACGACAAGATAATCAAAAAGAATACAGTCCCAATGGCGCAATTTTTATTGGCACAGTTGAAGAGTATCTTAAAAA
GAAACATTTTTTTGGCGCTGATAGCTTGGCTTATATTATGAATAAGGCTGATTCAATAGATATTGATGATAGGCTGGATT
TTGAATTTGCTATTTCACGGATGTTACAAAAAAATAAAAATAAAATAGACAAAGAAGCTGTTGCGCGACGAATTAAACAA
AAATTTTCGATAACTCATGCCATAAAACCGATCACATTAATAGGTCACTCCATATTTGATAACTGGGAGTTATCTGATTT
AGCAGGTAAGGAGGTAAATAATTATGGTGTCTCAGGTATTACATCTGAAGATTATTATAACCTTATCCTTGATGCTAATC
TCATAAAAGAAATTGGTGATGTGGTTTTTTTAATGTTGGGTACAAATGATATTGTTATTCAGGGTTGGGATGAGAATGAC
ACCTTAAGATGGCTCATGAAAATAATTGATAAAATAGTAAAACTTAATCCAAATGTAATTATCTACTTTTTATCATTGCC
TCCAGTTAATGGAAGGGTTGATAGAAATAATAAAGTCATTGAGCATTTGAATGCTTTCTTGTTTAAGGGTTTAGATAAAA
TTAATCACGTCAGATGGGTATCACTTTCTGATATGTTTTATGATGACTTTGGGAATTTATCTGCTGATTTTACATATGAT
GGGTTACATTTCAACGGAAAAGCATATAGACAACTAAAAAAAGAACTTATGGAGTTAATAAAATGA

Upstream 100 bases:

>100_bases
TGTATTGGTATGATATCTTAGGCAAGAAGGCGGAAAAAAATTTCGATGAGGATCAATTAATAAGTCATTCTGGATTCGAT
GAACAGGAGATCTAATTTAA

Downstream 100 bases:

>100_bases
AAAAGATTTTATATGTAACAGGTTCTCGTGCTGAATATGGAATAATGAAAAGATTATTACAGCAACTAAAAGAAGATGAT
AGTATAGATCTATCTATAGT

Product: NnaC

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTNRIAIIPARAGSKGLPNKNVLMLIDKPLIAYTIEAAKESQCFNKIIVSTDSLEYKSIAERYGAEVIIRSEELASDTAT
TYMVIENVLSHNKDCDYFMLLQPTSPFRNAHHIKEAITLFEGDVEANFLVSMTESEISSDLMKTLDSSMRLSNFNNDYSG
YRRQDNQKEYSPNGAIFIGTVEEYLKKKHFFGADSLAYIMNKADSIDIDDRLDFEFAISRMLQKNKNKIDKEAVARRIKQ
KFSITHAIKPITLIGHSIFDNWELSDLAGKEVNNYGVSGITSEDYYNLILDANLIKEIGDVVFLMLGTNDIVIQGWDEND
TLRWLMKIIDKIVKLNPNVIIYFLSLPPVNGRVDRNNKVIEHLNAFLFKGLDKINHVRWVSLSDMFYDDFGNLSADFTYD
GLHFNGKAYRQLKKELMELIK

Sequences:

>Translated_421_residues
MTNRIAIIPARAGSKGLPNKNVLMLIDKPLIAYTIEAAKESQCFNKIIVSTDSLEYKSIAERYGAEVIIRSEELASDTAT
TYMVIENVLSHNKDCDYFMLLQPTSPFRNAHHIKEAITLFEGDVEANFLVSMTESEISSDLMKTLDSSMRLSNFNNDYSG
YRRQDNQKEYSPNGAIFIGTVEEYLKKKHFFGADSLAYIMNKADSIDIDDRLDFEFAISRMLQKNKNKIDKEAVARRIKQ
KFSITHAIKPITLIGHSIFDNWELSDLAGKEVNNYGVSGITSEDYYNLILDANLIKEIGDVVFLMLGTNDIVIQGWDEND
TLRWLMKIIDKIVKLNPNVIIYFLSLPPVNGRVDRNNKVIEHLNAFLFKGLDKINHVRWVSLSDMFYDDFGNLSADFTYD
GLHFNGKAYRQLKKELMELIK
>Mature_420_residues
TNRIAIIPARAGSKGLPNKNVLMLIDKPLIAYTIEAAKESQCFNKIIVSTDSLEYKSIAERYGAEVIIRSEELASDTATT
YMVIENVLSHNKDCDYFMLLQPTSPFRNAHHIKEAITLFEGDVEANFLVSMTESEISSDLMKTLDSSMRLSNFNNDYSGY
RRQDNQKEYSPNGAIFIGTVEEYLKKKHFFGADSLAYIMNKADSIDIDDRLDFEFAISRMLQKNKNKIDKEAVARRIKQK
FSITHAIKPITLIGHSIFDNWELSDLAGKEVNNYGVSGITSEDYYNLILDANLIKEIGDVVFLMLGTNDIVIQGWDENDT
LRWLMKIIDKIVKLNPNVIIYFLSLPPVNGRVDRNNKVIEHLNAFLFKGLDKINHVRWVSLSDMFYDDFGNLSADFTYDG
LHFNGKAYRQLKKELMELIK

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=220, Percent_Identity=30, Blast_Score=90, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329
- InterPro:   IPR013830
- InterPro:   IPR013831 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 48143; Mature: 48011

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRIAIIPARAGSKGLPNKNVLMLIDKPLIAYTIEAAKESQCFNKIIVSTDSLEYKSIA
CCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHH
ERYGAEVIIRSEELASDTATTYMVIENVLSHNKDCDYFMLLQPTSPFRNAHHIKEAITLF
HHCCCEEEEECHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
EGDVEANFLVSMTESEISSDLMKTLDSSMRLSNFNNDYSGYRRQDNQKEYSPNGAIFIGT
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEC
VEEYLKKKHFFGADSLAYIMNKADSIDIDDRLDFEFAISRMLQKNKNKIDKEAVARRIKQ
HHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
KFSITHAIKPITLIGHSIFDNWELSDLAGKEVNNYGVSGITSEDYYNLILDANLIKEIGD
HHHHHHHCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCHHEEEECHHHHHHHHH
VVFLMLGTNDIVIQGWDENDTLRWLMKIIDKIVKLNPNVIIYFLSLPPVNGRVDRNNKVI
HEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCHHHH
EHLNAFLFKGLDKINHVRWVSLSDMFYDDFGNLSADFTYDGLHFNGKAYRQLKKELMELI
HHHHHHHHHHHHHHCCEEEEEEHHHHHHHCCCCCCCEEECCEEECCHHHHHHHHHHHHHH
K
C
>Mature Secondary Structure 
TNRIAIIPARAGSKGLPNKNVLMLIDKPLIAYTIEAAKESQCFNKIIVSTDSLEYKSIA
CCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHH
ERYGAEVIIRSEELASDTATTYMVIENVLSHNKDCDYFMLLQPTSPFRNAHHIKEAITLF
HHCCCEEEEECHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
EGDVEANFLVSMTESEISSDLMKTLDSSMRLSNFNNDYSGYRRQDNQKEYSPNGAIFIGT
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEC
VEEYLKKKHFFGADSLAYIMNKADSIDIDDRLDFEFAISRMLQKNKNKIDKEAVARRIKQ
HHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
KFSITHAIKPITLIGHSIFDNWELSDLAGKEVNNYGVSGITSEDYYNLILDANLIKEIGD
HHHHHHHCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCHHEEEECHHHHHHHHH
VVFLMLGTNDIVIQGWDENDTLRWLMKIIDKIVKLNPNVIIYFLSLPPVNGRVDRNNKVI
HEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCHHHH
EHLNAFLFKGLDKINHVRWVSLSDMFYDDFGNLSADFTYDGLHFNGKAYRQLKKELMELI
HHHHHHHHHHHHHHCCEEEEEEHHHHHHHCCCCCCCEEECCEEECCHHHHHHHHHHHHHH
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2549035 [H]