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The map label for this gene is neuC [H]

Identifier: 218695660

GI number: 218695660

Start: 2337896

End: 2339059

Strand: Reverse

Name: neuC [H]

Synonym: EC55989_2293

Alternate gene names: 218695660

Gene position: 2339059-2337896 (Counterclockwise)

Preceding gene: 218695661

Following gene: 218695659

Centisome position: 45.38

GC content: 31.79

Gene sequence:

>1164_bases
ATGAAAAAGATTTTATATGTAACAGGTTCTCGTGCTGAATATGGAATAATGAAAAGATTATTACAGCAACTAAAAGAAGA
TGATAGTATAGATCTATCTATAGTTGCAACTGGAATGCACTGTGATAAGAAGTATGGAATGACATACAAAGTTATTGAAA
ATGATGGTTTTCGTGTCGATAAAATAATAGATATCGAGATTAATAATGACACGAACGCTGAGATAATAAAAACCATGTCG
AGATGTTTATCTGAATTTGGTATATATTTTCAAGATAATAAGTTTGATGCTGTGATGATACTTGGGGATAGGTATGAAAT
CATGTCGGTAGCATTAGCAGCAGCTATGCATAACTTACCAATTATTCATTTTCATGGAGGTGAGAAAACTTTAGGTAATT
ATGACGAATTTATTAGGCATTCAATCACTAAAATGAGTTCATTACATCTGGCCTCAACGCATGAATACAGAAAAAGGATA
ATTCAGATGGGGGAGCATCCATCTAACGTTTATGATATAGGTGCTCTTGGAGCTGAAAATTCACTTTTACTTACTCTACC
ACCAAAAGATGTTCTTGAACAAAAATTTGGAGGGTTATCTAAACCTTATTTTGTGGTTGTTTTTCATCCTGAAACGCTTA
GTGGTGTTTCTCCTGAAATTCAAGTTCAATCTTTATTAAAAAGTTTACACTCCTTCATTAAAAAATATAATTTTGTTTTC
ATTGGTTCTAATTCTGACACTGGTTCAGACAAAATCACACAAAAAATTAAAAATTTTTGTAAAGAGAATAATACGAAATA
TTTTGTTTCTATACTACCAGAGGAATATCTTGCACTATGTAAGTACTCGCAAGGTTTAATAGGTAATTCTTCTTCTGGTT
TAATTGAAGTTCCTTCGCTTGGAGTACCCACAGTTAATATTGGAGACAGGCAAAAAGGGAGGGTTCACGGAACTACTGTT
ATAAATTGTGAATGCAGTACTGAAGGCATTTCTGAAGCAATAAAAAAATGCTTAGATGAACATTACATTAATGGTATTAA
GAATGCGGTGAACCCTTATTATAAACATAATGTGATGAATAATGCCTATAAGCATATCAAAGAATTCCTGTTAAGTAACC
ATGAACAATATAAGGATTTTTATGATGTGTCATTTGAACTTTAA

Upstream 100 bases:

>100_bases
ATGACTTTGGGAATTTATCTGCTGATTTTACATATGATGGGTTACATTTCAACGGAAAAGCATATAGACAACTAAAAAAA
GAACTTATGGAGTTAATAAA

Downstream 100 bases:

>100_bases
GGTAACAGCCCTAAGTTTATTTAAGCCTTACTGTAAACTAGGTGTTTAAAAATAGACAAACCTTTCGTAGTATAGAGCTA
TATAATGAAAATGAGAAATA

Product: NnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKKILYVTGSRAEYGIMKRLLQQLKEDDSIDLSIVATGMHCDKKYGMTYKVIENDGFRVDKIIDIEINNDTNAEIIKTMS
RCLSEFGIYFQDNKFDAVMILGDRYEIMSVALAAAMHNLPIIHFHGGEKTLGNYDEFIRHSITKMSSLHLASTHEYRKRI
IQMGEHPSNVYDIGALGAENSLLLTLPPKDVLEQKFGGLSKPYFVVVFHPETLSGVSPEIQVQSLLKSLHSFIKKYNFVF
IGSNSDTGSDKITQKIKNFCKENNTKYFVSILPEEYLALCKYSQGLIGNSSSGLIEVPSLGVPTVNIGDRQKGRVHGTTV
INCECSTEGISEAIKKCLDEHYINGIKNAVNPYYKHNVMNNAYKHIKEFLLSNHEQYKDFYDVSFEL

Sequences:

>Translated_387_residues
MKKILYVTGSRAEYGIMKRLLQQLKEDDSIDLSIVATGMHCDKKYGMTYKVIENDGFRVDKIIDIEINNDTNAEIIKTMS
RCLSEFGIYFQDNKFDAVMILGDRYEIMSVALAAAMHNLPIIHFHGGEKTLGNYDEFIRHSITKMSSLHLASTHEYRKRI
IQMGEHPSNVYDIGALGAENSLLLTLPPKDVLEQKFGGLSKPYFVVVFHPETLSGVSPEIQVQSLLKSLHSFIKKYNFVF
IGSNSDTGSDKITQKIKNFCKENNTKYFVSILPEEYLALCKYSQGLIGNSSSGLIEVPSLGVPTVNIGDRQKGRVHGTTV
INCECSTEGISEAIKKCLDEHYINGIKNAVNPYYKHNVMNNAYKHIKEFLLSNHEQYKDFYDVSFEL
>Mature_387_residues
MKKILYVTGSRAEYGIMKRLLQQLKEDDSIDLSIVATGMHCDKKYGMTYKVIENDGFRVDKIIDIEINNDTNAEIIKTMS
RCLSEFGIYFQDNKFDAVMILGDRYEIMSVALAAAMHNLPIIHFHGGEKTLGNYDEFIRHSITKMSSLHLASTHEYRKRI
IQMGEHPSNVYDIGALGAENSLLLTLPPKDVLEQKFGGLSKPYFVVVFHPETLSGVSPEIQVQSLLKSLHSFIKKYNFVF
IGSNSDTGSDKITQKIKNFCKENNTKYFVSILPEEYLALCKYSQGLIGNSSSGLIEVPSLGVPTVNIGDRQKGRVHGTTV
INCECSTEGISEAIKKCLDEHYINGIKNAVNPYYKHNVMNNAYKHIKEFLLSNHEQYKDFYDVSFEL

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=329, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI4885285, Length=329, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI190014632, Length=329, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI298566325, Length=297, Percent_Identity=28.6195286195286, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI298566315, Length=274, Percent_Identity=24.0875912408759, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: NA

Molecular weight: Translated: 43786; Mature: 43786

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILYVTGSRAEYGIMKRLLQQLKEDDSIDLSIVATGMHCDKKYGMTYKVIENDGFRVD
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHCCCEEEEEECCCEEEE
KIIDIEINNDTNAEIIKTMSRCLSEFGIYFQDNKFDAVMILGDRYEIMSVALAAAMHNLP
EEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHCCC
IIHFHGGEKTLGNYDEFIRHSITKMSSLHLASTHEYRKRIIQMGEHPSNVYDIGALGAEN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
SLLLTLPPKDVLEQKFGGLSKPYFVVVFHPETLSGVSPEIQVQSLLKSLHSFIKKYNFVF
CEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEE
IGSNSDTGSDKITQKIKNFCKENNTKYFVSILPEEYLALCKYSQGLIGNSSSGLIEVPSL
EECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCEEECCCC
GVPTVNIGDRQKGRVHGTTVINCECSTEGISEAIKKCLDEHYINGIKNAVNPYYKHNVMN
CCCEECCCCCCCCEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NAYKHIKEFLLSNHEQYKDFYDVSFEL
HHHHHHHHHHHCCCHHHHHHHCEEECC
>Mature Secondary Structure
MKKILYVTGSRAEYGIMKRLLQQLKEDDSIDLSIVATGMHCDKKYGMTYKVIENDGFRVD
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHCCCEEEEEECCCEEEE
KIIDIEINNDTNAEIIKTMSRCLSEFGIYFQDNKFDAVMILGDRYEIMSVALAAAMHNLP
EEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHCCC
IIHFHGGEKTLGNYDEFIRHSITKMSSLHLASTHEYRKRIIQMGEHPSNVYDIGALGAEN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
SLLLTLPPKDVLEQKFGGLSKPYFVVVFHPETLSGVSPEIQVQSLLKSLHSFIKKYNFVF
CEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEE
IGSNSDTGSDKITQKIKNFCKENNTKYFVSILPEEYLALCKYSQGLIGNSSSGLIEVPSL
EECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCEEECCCC
GVPTVNIGDRQKGRVHGTTVINCECSTEGISEAIKKCLDEHYINGIKNAVNPYYKHNVMN
CCCEECCCCCCCCEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NAYKHIKEFLLSNHEQYKDFYDVSFEL
HHHHHHHHHHHCCCHHHHHHHCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]