Click here to switch to the map view.

The map label for this gene is arcB [H]

Identifier: 218692637

GI number: 218692637

Start: 5042060

End: 5043091

Strand: Reverse

Name: arcB [H]

Synonym: ECED1_5103

Alternate gene names: 218692637

Gene position: 5043091-5042060 (Counterclockwise)

Preceding gene: 218692638

Following gene: 218692636

Centisome position: 96.8

GC content: 48.16

Gene sequence:

>1032_bases
TTGATCCATTTTTATAAGGACATCCCCATGGCTACTTCACTGAAAAACCGTAATTTTCTTAAGCTGCTTGATTACACCCC
AGCAGAGATTCAATACCTGATTGATTTGGCTATCAATCTTAAAGCCGCCAAGAAATCTGGAAACGAAAAACAAACGCTGG
TCGGTAAAAACATTGCGTTGATTTTTGAAAAATCCTCTACCCGTACCCGCTGTGCCTTTGAAGTCGCGGCCTTTGATCAA
GGTGCGCAGGTGACTTACATCGGCCCCAGCGGCTCACAAATCGGCCATAAAGAATCAATGAAAGATACCGCTCGTGTACT
CGGACGCATGTATGACGGTATTGAGTATCGCGGTTATGGTCAGAATATCGTTGAAGAATTAGGTGAGTTCGCTGGTGTTC
CGGTATGGAACGGACTGACCAATGAATTTCACCCGACACAGATCCTCGCGGATTTAATGACCATGCTGGAACATGCGCCA
GGCAAAACGCTGCCAGAGCTGAGCTTTGCGTATCTTGGTGATGCCCGAAATAACATGGGGAACTCGCTGATGGTTGGTGC
TGCAAAAATGGGGATGGATATCCGTCTGGTGGCACCGAAATCTTTCTGGCCAGATGAAGCGCTGGTAACACAATGCCGTG
AGATCGCCAGCGTGACTGGGGCGAGAATCACCCTGACAGAGAATGTGGAAGAAGGCGTATACGACGTGGATTTTCTCTAT
ACGGATGTTTGGGTTTCGATGGGAGAGCCAAAAGAAGCCTGGGCAGAACGAGTGAGTCTTATGACACCTTATCAGATCAA
TCAACAGGTGATTACTGCCACGCGTAACCCTGAAGTCAAATTTATGCACTGCCTGCCCGCCTTCCATAATGAGCACACCA
CAGTAGGACGCGAGATCGAGATGGCCTACGGCCTCAAAGGACTGGAAGTAACTGATGAGGTTTTTGAATCTGCCCACTCC
ATTGTTTTCGATGAAGCAGAAAACCGGATGCACACCATTAAAGCGGTGATGGTAGCAACTCTCGGCGACTAA

Upstream 100 bases:

>100_bases
GCCGGGGCATTGCAGGGATCGGCTCTCTTGCAGATGGTCCGGAAATTCTCGCCGGAGACAAAGGCACTCTTATTCGCCTT
GATACCCCCCATAACCACGC

Downstream 100 bases:

>100_bases
CCCTGACGGGCATGCGTCGACGAGTGGCGTATGCCCGTGATTATGGAGATCACATTATGGGTAAATTCAAATTTCCCACC
GCTTATACCATCTTGTTCGT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MIHFYKDIPMATSLKNRNFLKLLDYTPAEIQYLIDLAINLKAAKKSGNEKQTLVGKNIALIFEKSSTRTRCAFEVAAFDQ
GAQVTYIGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYGQNIVEELGEFAGVPVWNGLTNEFHPTQILADLMTMLEHAP
GKTLPELSFAYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPDEALVTQCREIASVTGARITLTENVEEGVYDVDFLY
TDVWVSMGEPKEAWAERVSLMTPYQINQQVITATRNPEVKFMHCLPAFHNEHTTVGREIEMAYGLKGLEVTDEVFESAHS
IVFDEAENRMHTIKAVMVATLGD

Sequences:

>Translated_343_residues
MIHFYKDIPMATSLKNRNFLKLLDYTPAEIQYLIDLAINLKAAKKSGNEKQTLVGKNIALIFEKSSTRTRCAFEVAAFDQ
GAQVTYIGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYGQNIVEELGEFAGVPVWNGLTNEFHPTQILADLMTMLEHAP
GKTLPELSFAYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPDEALVTQCREIASVTGARITLTENVEEGVYDVDFLY
TDVWVSMGEPKEAWAERVSLMTPYQINQQVITATRNPEVKFMHCLPAFHNEHTTVGREIEMAYGLKGLEVTDEVFESAHS
IVFDEAENRMHTIKAVMVATLGD
>Mature_343_residues
MIHFYKDIPMATSLKNRNFLKLLDYTPAEIQYLIDLAINLKAAKKSGNEKQTLVGKNIALIFEKSSTRTRCAFEVAAFDQ
GAQVTYIGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYGQNIVEELGEFAGVPVWNGLTNEFHPTQILADLMTMLEHAP
GKTLPELSFAYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPDEALVTQCREIASVTGARITLTENVEEGVYDVDFLY
TDVWVSMGEPKEAWAERVSLMTPYQINQQVITATRNPEVKFMHCLPAFHNEHTTVGREIEMAYGLKGLEVTDEVFESAHS
IVFDEAENRMHTIKAVMVATLGD

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=331, Percent_Identity=36.5558912386707, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI18105007, Length=341, Percent_Identity=23.4604105571848, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790703, Length=327, Percent_Identity=69.1131498470948, Blast_Score=489, Evalue=1e-140,
Organism=Escherichia coli, GI1786469, Length=333, Percent_Identity=66.966966966967, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI48994908, Length=385, Percent_Identity=25.1948051948052, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367364, Length=250, Percent_Identity=30, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322373, Length=329, Percent_Identity=33.1306990881459, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6322331, Length=293, Percent_Identity=24.5733788395904, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24642586, Length=236, Percent_Identity=26.6949152542373, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 38274; Mature: 38274

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHFYKDIPMATSLKNRNFLKLLDYTPAEIQYLIDLAINLKAAKKSGNEKQTLVGKNIAL
CCEEECCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHHEEEHHHCCCCCCCEEECCCEEE
IFEKSSTRTRCAFEVAAFDQGAQVTYIGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYG
EEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCC
QNIVEELGEFAGVPVWNGLTNEFHPTQILADLMTMLEHAPGKTLPELSFAYLGDARNNMG
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHCCCC
NSLMVGAAKMGMDIRLVAPKSFWPDEALVTQCREIASVTGARITLTENVEEGVYDVDFLY
CEEEEEHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEHHHEE
TDVWVSMGEPKEAWAERVSLMTPYQINQQVITATRNPEVKFMHCLPAFHNEHTTVGREIE
EEHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEH
MAYGLKGLEVTDEVFESAHSIVFDEAENRMHTIKAVMVATLGD
HHHCCCCCCHHHHHHHHHHHEEHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MIHFYKDIPMATSLKNRNFLKLLDYTPAEIQYLIDLAINLKAAKKSGNEKQTLVGKNIAL
CCEEECCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHHEEEHHHCCCCCCCEEECCCEEE
IFEKSSTRTRCAFEVAAFDQGAQVTYIGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYG
EEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCC
QNIVEELGEFAGVPVWNGLTNEFHPTQILADLMTMLEHAPGKTLPELSFAYLGDARNNMG
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHCCCC
NSLMVGAAKMGMDIRLVAPKSFWPDEALVTQCREIASVTGARITLTENVEEGVYDVDFLY
CEEEEEHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEHHHEE
TDVWVSMGEPKEAWAERVSLMTPYQINQQVITATRNPEVKFMHCLPAFHNEHTTVGREIE
EEHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEH
MAYGLKGLEVTDEVFESAHSIVFDEAENRMHTIKAVMVATLGD
HHHCCCCCCHHHHHHHHHHHEEHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]