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The map label for this gene is fbaA [H]

Identifier: 218691941

GI number: 218691941

Start: 4266798

End: 4267658

Strand: Reverse

Name: fbaA [H]

Synonym: ECED1_4343

Alternate gene names: 218691941

Gene position: 4267658-4266798 (Counterclockwise)

Preceding gene: 218691942

Following gene: 218691940

Centisome position: 81.92

GC content: 52.15

Gene sequence:

>861_bases
ATGTTAGTTTCGATGAAAGAATTACTGCAACCTACCCGCCAGCACGGCTTTGCCATTGGCGCATTTAATGTGGCGGATAA
CTGTTTCCTTCGCGCAGTCGTGGATGAAGCAGAAGCGACAAATACTCCGGCGATTATTGCCATCCATCCCAGCGAACATG
ATTTTGTGGGCGATGCCTTTTTCGCTCACGTTCGCGAAATTACCCAGCGTAGTCCGGTCCCGTTTGTACTGCACCTCGAT
CATGGTGCCTCTGTAGAGCATGTTTTGCGTGCGATTCGCTGCGGATTTACCTCAGTAATGATCGACGGTTCGCTGCTGCC
GTATGAAGAAAACGTGGCGCTGACCGCAGAAGTGGTTCGCCTCGCTCACGCGGTTGGCGTGTCGGTTGAGGGTGAACTGG
AAACCATCGGACAAACAGGAACGTCGGTAGAAGGTGGTGTTTCACAAGTGACCTACACAGATCCGGCGCAGGCCGCCGAT
TTTATTGCTCGTACAGGTGCCGACACACTGGCTGTGGCGATTGGTACAGCGCATGGCATCTATCCAAAAGGGATGCAGCC
GAAGCTGCAAATGAACATTTTGCGCGACATTGCCGGACGTATTGATATTCCGCTGGTGCTACACGGTGGTTCGGCAAACC
CGGACGCGGAGATTGCTGAATCAGTTACGCTCGGCGTCGGCAAAATCAATATCTCCAGCGATATGAAATACGCCTATTTC
CAGAAAGTGCGTGAAATTCTCGCTAAAGAGAGCTGGTGGGACCCGAACGTCATCTATCCGGATGCGATTAACGCGGCGCG
GGAAGTCATTCGCCACAAAATGAAACTGTTCGGTTCGTTCGGTAAAGCATCACTGTACTAA

Upstream 100 bases:

>100_bases
GCTCTATCGGCAAAGCCTGATTCATTTTCTGTCATGGCCTTTATGCCAGTGCAATAACGCACCGGCAGGGCGGACTACAC
GCTGAAACTGGAGATTTAAC

Downstream 100 bases:

>100_bases
GCCAGAAGGGCGGGGTGACCCGCCTTTTACGCAACAAGGAACGAGATATGCACTATCTGGGGTTGGATATTGGTGGGACC
AAAATCGCCGCCGTTGTCAT

Product: hypothetical protein

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MLVSMKELLQPTRQHGFAIGAFNVADNCFLRAVVDEAEATNTPAIIAIHPSEHDFVGDAFFAHVREITQRSPVPFVLHLD
HGASVEHVLRAIRCGFTSVMIDGSLLPYEENVALTAEVVRLAHAVGVSVEGELETIGQTGTSVEGGVSQVTYTDPAQAAD
FIARTGADTLAVAIGTAHGIYPKGMQPKLQMNILRDIAGRIDIPLVLHGGSANPDAEIAESVTLGVGKINISSDMKYAYF
QKVREILAKESWWDPNVIYPDAINAAREVIRHKMKLFGSFGKASLY

Sequences:

>Translated_286_residues
MLVSMKELLQPTRQHGFAIGAFNVADNCFLRAVVDEAEATNTPAIIAIHPSEHDFVGDAFFAHVREITQRSPVPFVLHLD
HGASVEHVLRAIRCGFTSVMIDGSLLPYEENVALTAEVVRLAHAVGVSVEGELETIGQTGTSVEGGVSQVTYTDPAQAAD
FIARTGADTLAVAIGTAHGIYPKGMQPKLQMNILRDIAGRIDIPLVLHGGSANPDAEIAESVTLGVGKINISSDMKYAYF
QKVREILAKESWWDPNVIYPDAINAAREVIRHKMKLFGSFGKASLY
>Mature_286_residues
MLVSMKELLQPTRQHGFAIGAFNVADNCFLRAVVDEAEATNTPAIIAIHPSEHDFVGDAFFAHVREITQRSPVPFVLHLD
HGASVEHVLRAIRCGFTSVMIDGSLLPYEENVALTAEVVRLAHAVGVSVEGELETIGQTGTSVEGGVSQVTYTDPAQAAD
FIARTGADTLAVAIGTAHGIYPKGMQPKLQMNILRDIAGRIDIPLVLHGGSANPDAEIAESVTLGVGKINISSDMKYAYF
QKVREILAKESWWDPNVIYPDAINAAREVIRHKMKLFGSFGKASLY

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=285, Percent_Identity=34.3859649122807, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1788072, Length=288, Percent_Identity=36.4583333333333, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI87082041, Length=284, Percent_Identity=34.8591549295775, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1789293, Length=285, Percent_Identity=24.9122807017544, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=294, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30919; Mature: 30919

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSMKELLQPTRQHGFAIGAFNVADNCFLRAVVDEAEATNTPAIIAIHPSEHDFVGDAF
CCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
FAHVREITQRSPVPFVLHLDHGASVEHVLRAIRCGFTSVMIDGSLLPYEENVALTAEVVR
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHEEECCCCCCCCCCCHHHHHHHH
LAHAVGVSVEGELETIGQTGTSVEGGVSQVTYTDPAQAADFIARTGADTLAVAIGTAHGI
HHHHHCCCCCCCHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCEEEEEECCCCC
YPKGMQPKLQMNILRDIAGRIDIPLVLHGGSANPDAEIAESVTLGVGKINISSDMKYAYF
CCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHEEEEEEEECCCCCHHHHH
QKVREILAKESWWDPNVIYPDAINAAREVIRHKMKLFGSFGKASLY
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLVSMKELLQPTRQHGFAIGAFNVADNCFLRAVVDEAEATNTPAIIAIHPSEHDFVGDAF
CCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
FAHVREITQRSPVPFVLHLDHGASVEHVLRAIRCGFTSVMIDGSLLPYEENVALTAEVVR
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHEEECCCCCCCCCCCHHHHHHHH
LAHAVGVSVEGELETIGQTGTSVEGGVSQVTYTDPAQAADFIARTGADTLAVAIGTAHGI
HHHHHCCCCCCCHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCEEEEEECCCCC
YPKGMQPKLQMNILRDIAGRIDIPLVLHGGSANPDAEIAESVTLGVGKINISSDMKYAYF
CCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHEEEEEEEECCCCCHHHHH
QKVREILAKESWWDPNVIYPDAINAAREVIRHKMKLFGSFGKASLY
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]