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The map label for this gene is cysJ [H]

Identifier: 218690884

GI number: 218690884

Start: 3145896

End: 3147695

Strand: Reverse

Name: cysJ [H]

Synonym: ECED1_3213

Alternate gene names: 218690884

Gene position: 3147695-3145896 (Counterclockwise)

Preceding gene: 218690889

Following gene: 218690883

Centisome position: 60.42

GC content: 56.11

Gene sequence:

>1800_bases
ATGACGACACAGGTCCCACCTTCCGCGTTGCTTCCGTTGAACCCGGAGCAACTGGCACGCCTTCAGGCGGCCACGACCGA
TTTAACTCCTACCCAGCTTGCCTGGGTTTCTGGCTATTTCTGGGGCGTGCTCAACCAGCAGCCTGCTGCGCTTGCAGCGA
CGCCAGCGCCCGCCGCAGAAATGCCGGGTATAACTATTATCTCCGCCTCGCAAACTGGCAATGCGCGTCGGGTTGCTGAA
GCATTACGCGATGATTTATTAGCGGCAAAACTGAACGTTAAGCTGGTGAACGCGGGCGACTATAAATTCAAACAAATCGC
CAGCGAAAAACTGCTTATCGTGGTGACGTCAACGCAAGGGGAAGGGGAACCGCCGGAAGAAGCCGTCGCGCTGCATAAGT
TCCTGTTCTCCAAAAAAGCGCAAAAGCTGGAAAACACCGCGTTTGCCGTGTTTAGCCTCGGCGATAGCTCTTATGAATTT
TTCTGCCAGTCCGGGAAAGATTTTGACAGTAAGCTGGCGGAACTGGGCGGTGAACGCCTGCTCGACCGTGTCGATGCCGA
CGTTGAATACCAGCCTGCTGCCAGCGAGTGGCGCGCCCGCGTGGTTGATGCGCTTAAATCGCGTGCGCCTGTCGCGGCAC
CTTCGCAATCCGTCGCTACTGGCACGGTAAATGAAATCCACACCAGCCCGTATAGCAAAGACGCGCCGCTGGTGGCGAGC
CTCTCTGTTAACCAGAAAATTACCGGGCGTAACTCTGAAAAAGACGTTCGTCACATTGAAATTGACTTAGGTGACTCTGG
CCTGCGTTACCAGCCGGGTGACGCGCTGGGCGTCTGGTATCAAAACGATCCGGCACTGGTGAAAGAACTTGTCGAACTGC
TGTGGCTGAAAGGCGATGAACCTGTCACCGTCGAGGGCAAAACGTTGCCTCTGAACGAAGCGCTACAGTGGCACTTCGAA
CTGACCGTCAACACCGCCAACATTGTTGAGAACTATGCCACGCTTACCCGCAGCGAAACGCTGCTGCCGCTGGTGGGCGA
TAAAGCGAAGTTACAGCATTACGCCGCGACGACGCCGATTGTCGACATGGTGCGTTTCTCTCCGGCGCAACTGGATGCCG
AAGCGCTGATTAATCTGCTGCGCCCGCTGACACCGCGCCTGTATTCCATCGCCTCCTCGCAGGCGGAAGTCGAGAACGAA
GTGCACGTTACCGTTGGTGTGGTGCGTTACGACGTGGAAGGCCGTGCCCGTGCCGGTGGTGCCTCCAGCTTCCTCGCGGA
TCGTGTGGAAGAAGAGGGTGAAGTCCGCGTCTTTATCGAACATAACGACAACTTCCGCCTGCCAACCAATCCGGAAACCC
CGGTGATCATGATTGGCCCTGGCACCGGCATCGCGCCGTTCCGTGCCTTTATGCAGCAGCGTGCTGCCGACGAAGCGCCG
GGTAAAAACTGGCTATTCTTTGGCAACCCACACTTTACGGAAGATTTCCTCTACCAGGTGGAATGGCAGCGTTACGTCAA
AGAAGGCGTGCTGACGCGCATCGATCTCGCCTGGTCGCGCGATCAAAAAGAAAAAATTTACGTACAAGACAAACTGCGCG
AACAGGGCGCAGAGCTGTGGCGCTGGATCAATGATGGTGCCCACATTTATGTCTGCGGCGACGCTAATCGCATGGCGAAA
GACGTTGAGCAGGCACTTCTGGAAGTGATTGCCGAATTTGGTGGCATGGACACCGAAGCGGCGGATGAATTTTTAAGTGA
GCTGCGCGTAGAGCGCCGTTATCAGCGAGATGTCTACTAA

Upstream 100 bases:

>100_bases
TTAATCCACACCGTTTACCCCGTTAACCTTACCTTCTCTTCTGTTTTATGGGCGCTGACAGGGCGCAGAAACAGCTTTGC
TTACTGGAACATAACAACGC

Downstream 100 bases:

>100_bases
TGAGCGAAAAACATCCTGGGCCTTTAGTGGTCGAAGGAAAACTGACAGACGCCGAGCGCATGAAGCTTGAAAGCAACTAC
CTGCGCGGCACCATTGCGGA

Product: sulfite reductase subunit alpha

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAEMPGITIISASQTGNARRVAE
ALRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKAQKLENTAFAVFSLGDSSYEF
FCQSGKDFDSKLAELGGERLLDRVDADVEYQPAASEWRARVVDALKSRAPVAAPSQSVATGTVNEIHTSPYSKDAPLVAS
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKTLPLNEALQWHFE
LTVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPIVDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENE
VHVTVGVVRYDVEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPTNPETPVIMIGPGTGIAPFRAFMQQRAADEAP
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDANRMAK
DVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY

Sequences:

>Translated_599_residues
MTTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAEMPGITIISASQTGNARRVAE
ALRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKAQKLENTAFAVFSLGDSSYEF
FCQSGKDFDSKLAELGGERLLDRVDADVEYQPAASEWRARVVDALKSRAPVAAPSQSVATGTVNEIHTSPYSKDAPLVAS
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKTLPLNEALQWHFE
LTVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPIVDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENE
VHVTVGVVRYDVEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPTNPETPVIMIGPGTGIAPFRAFMQQRAADEAP
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDANRMAK
DVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY
>Mature_598_residues
TTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAEMPGITIISASQTGNARRVAEA
LRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKAQKLENTAFAVFSLGDSSYEFF
CQSGKDFDSKLAELGGERLLDRVDADVEYQPAASEWRARVVDALKSRAPVAAPSQSVATGTVNEIHTSPYSKDAPLVASL
SVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKTLPLNEALQWHFEL
TVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPIVDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENEV
HVTVGVVRYDVEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPTNPETPVIMIGPGTGIAPFRAFMQQRAADEAPG
KNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDANRMAKD
VEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=601, Percent_Identity=30.2828618968386, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI7657393, Length=601, Percent_Identity=29.2845257903494, Blast_Score=226, Evalue=6e-59,
Organism=Homo sapiens, GI24041029, Length=596, Percent_Identity=30.7046979865772, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI221316709, Length=601, Percent_Identity=29.2845257903494, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI221316705, Length=610, Percent_Identity=28.8524590163934, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI10835173, Length=651, Percent_Identity=30.1075268817204, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI221316707, Length=531, Percent_Identity=29.5668549905838, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI40254422, Length=644, Percent_Identity=28.416149068323, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI169790956, Length=437, Percent_Identity=28.604118993135, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI169790958, Length=437, Percent_Identity=28.604118993135, Blast_Score=161, Evalue=2e-39,
Organism=Escherichia coli, GI1789123, Length=599, Percent_Identity=98.8313856427379, Blast_Score=1215, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17554134, Length=637, Percent_Identity=29.5133437990581, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17566446, Length=583, Percent_Identity=26.4150943396226, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17531441, Length=394, Percent_Identity=25.3807106598985, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321832, Length=636, Percent_Identity=27.9874213836478, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321143, Length=397, Percent_Identity=31.7380352644836, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325305, Length=626, Percent_Identity=23.0031948881789, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17137192, Length=624, Percent_Identity=28.2051282051282, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24582192, Length=510, Percent_Identity=30, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI78706872, Length=525, Percent_Identity=32.3809523809524, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24583543, Length=525, Percent_Identity=32.3809523809524, Blast_Score=185, Evalue=9e-47,
Organism=Drosophila melanogaster, GI78706876, Length=525, Percent_Identity=32.3809523809524, Blast_Score=185, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24660907, Length=595, Percent_Identity=26.0504201680672, Blast_Score=156, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24660903, Length=595, Percent_Identity=26.0504201680672, Blast_Score=156, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 66398; Mature: 66266

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAE
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHH
MPGITIISASQTGNARRVAEALRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQG
CCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHCCCCEEEEEECCCC
EGEPPEEAVALHKFLFSKKAQKLENTAFAVFSLGDSSYEFFCQSGKDFDSKLAELGGERL
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCCCHHHHHHHHCHHHH
LDRVDADVEYQPAASEWRARVVDALKSRAPVAAPSQSVATGTVNEIHTSPYSKDAPLVAS
HHHHCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEE
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDE
EECCCEECCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHCCCCC
PVTVEGKTLPLNEALQWHFELTVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPI
CEEECCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCH
VDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENEVHVTVGVVRYDVEGRARAGG
HHHHHCCCHHCCHHHHHHHHHCCCHHHHHHHCCHHHCCCCEEEEEEEEEEECCCCCCCCC
ASSFLADRVEEEGEVRVFIEHNDNFRLPTNPETPVIMIGPGTGIAPFRAFMQQRAADEAP
HHHHHHHHHCCCCCEEEEEEECCCEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKIYVQDKLREQGAELW
CCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHH
RWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAE
CCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHH
MPGITIISASQTGNARRVAEALRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQG
CCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHCCCCEEEEEECCCC
EGEPPEEAVALHKFLFSKKAQKLENTAFAVFSLGDSSYEFFCQSGKDFDSKLAELGGERL
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCCCHHHHHHHHCHHHH
LDRVDADVEYQPAASEWRARVVDALKSRAPVAAPSQSVATGTVNEIHTSPYSKDAPLVAS
HHHHCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEE
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDE
EECCCEECCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHCCCCC
PVTVEGKTLPLNEALQWHFELTVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPI
CEEECCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCH
VDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENEVHVTVGVVRYDVEGRARAGG
HHHHHCCCHHCCHHHHHHHHHCCCHHHHHHHCCHHHCCCCEEEEEEEEEEECCCCCCCCC
ASSFLADRVEEEGEVRVFIEHNDNFRLPTNPETPVIMIGPGTGIAPFRAFMQQRAADEAP
HHHHHHHHHCCCCCEEEEEEECCCEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKIYVQDKLREQGAELW
CCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHH
RWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA