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The map label for this gene is yjcR [H]

Identifier: 218551506

GI number: 218551506

Start: 4392560

End: 4393591

Strand: Direct

Name: yjcR [H]

Synonym: EFER_4289

Alternate gene names: 218551506

Gene position: 4392560-4393591 (Clockwise)

Preceding gene: 218551505

Following gene: 218551507

Centisome position: 95.73

GC content: 53.29

Gene sequence:

>1032_bases
ATGGAAAGTACGCCAAAAAACGCTACGCGCAATAAATTACCCGCGTTGATCCTGACCGTTGCGGCAGTCGTTGCTCTTGT
TTATGTGATCTGGCGTGTCGATAGCGCCCCGGCAACTAACGACGCTTACGCATCTGCGGATACCGTTGATGTGGTGCCAG
AAGTCAGTGGCCGCATTGTGGAACTTGCGGTCAAAGATAACCAACTGGTGAAACAGGGCGATCTTCTATTTCGTATTGAT
CCGCGCCCCTATGAAGCAAGCCTCGCAAAAGCCCAGGCGTCGCTGACCGCGCTGGATAAACAAATTATGCTCACCCAGCG
TAGCGTTGAAGCCCAGCAACTCGGAGCCGCGGCAGTGAAGACATCGGTGGAGAAAGCCCTGGCGATTGTTCATCAGACCA
GTAAAACCTTTCAACGTACCGAGTCTCTGTTGGCAGAGGGCTATGTATCAGATGAAGATGTGGATCGCGCCAGAACGGCC
CATCGCTCAGCACAGGTTGACTATGCAGCACTGTTACTACAGGCACAATCTGCGGTCAGTGGTGTGGGAGGCGTGGATGC
GCTGGTCGCCCAACGTGAGGCCGTTCTCGCCGATATTGCACTGACAAAGTTGCATCTGGAGATGGCTACCGTTCGTGCGC
CTTTTGATGGACGCGTGGTGTCGCTGAAAACATCTGTCGGGCAGTTTGCTTCGGCGATGCGGCCGATTTTCACACTGATC
GACACCCGCCACTGGTATGTCATCGCTAACTTCCGTGAAACAGAGCTGAATAATATCCGCGCCGGAACACCCGCGACAGT
TCGCCTGATGAGTGACAGCGGTAAAACCTTTGAAGGCAAAGTCGATTCCATTGGTTATGGCGTATTACCAGACGATGGCG
GCATGGTATTAGGTGGGCTACCACGTGTATCTCGCTCAATCAACTGGGTACGTGTTGCCCAGCGTTTCCCGGTAAAAATC
ATGGTAGATAACCCTGACCCTGAGATGTTCCGTATAGGTGCTTCGGCGGTTGCTAACCTTGAGCCACAATAA

Upstream 100 bases:

>100_bases
ACAACCTGTCATGTGCCGGGCTGGTTTACACCGCGCTGTTTGCCCTCTACTCCACGCTGTTCTGGCTGGTTTTTTTCTAA
CTTATTTTTGAGATGCGCTC

Downstream 100 bases:

>100_bases
TGAGCGCGCTCAACTACCTTCCGCTACCAATGGTTCGGCTGTTGGCTTTTCTTCATGAGGAGTTAAACGAACAGCGACCG
GGGCGTATGGCACAAACCTT

Product: multidrug resistance protein MdtN

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MESTPKNATRNKLPALILTVAAVVALVYVIWRVDSAPATNDAYASADTVDVVPEVSGRIVELAVKDNQLVKQGDLLFRID
PRPYEASLAKAQASLTALDKQIMLTQRSVEAQQLGAAAVKTSVEKALAIVHQTSKTFQRTESLLAEGYVSDEDVDRARTA
HRSAQVDYAALLLQAQSAVSGVGGVDALVAQREAVLADIALTKLHLEMATVRAPFDGRVVSLKTSVGQFASAMRPIFTLI
DTRHWYVIANFRETELNNIRAGTPATVRLMSDSGKTFEGKVDSIGYGVLPDDGGMVLGGLPRVSRSINWVRVAQRFPVKI
MVDNPDPEMFRIGASAVANLEPQ

Sequences:

>Translated_343_residues
MESTPKNATRNKLPALILTVAAVVALVYVIWRVDSAPATNDAYASADTVDVVPEVSGRIVELAVKDNQLVKQGDLLFRID
PRPYEASLAKAQASLTALDKQIMLTQRSVEAQQLGAAAVKTSVEKALAIVHQTSKTFQRTESLLAEGYVSDEDVDRARTA
HRSAQVDYAALLLQAQSAVSGVGGVDALVAQREAVLADIALTKLHLEMATVRAPFDGRVVSLKTSVGQFASAMRPIFTLI
DTRHWYVIANFRETELNNIRAGTPATVRLMSDSGKTFEGKVDSIGYGVLPDDGGMVLGGLPRVSRSINWVRVAQRFPVKI
MVDNPDPEMFRIGASAVANLEPQ
>Mature_343_residues
MESTPKNATRNKLPALILTVAAVVALVYVIWRVDSAPATNDAYASADTVDVVPEVSGRIVELAVKDNQLVKQGDLLFRID
PRPYEASLAKAQASLTALDKQIMLTQRSVEAQQLGAAAVKTSVEKALAIVHQTSKTFQRTESLLAEGYVSDEDVDRARTA
HRSAQVDYAALLLQAQSAVSGVGGVDALVAQREAVLADIALTKLHLEMATVRAPFDGRVVSLKTSVGQFASAMRPIFTLI
DTRHWYVIANFRETELNNIRAGTPATVRLMSDSGKTFEGKVDSIGYGVLPDDGGMVLGGLPRVSRSINWVRVAQRFPVKI
MVDNPDPEMFRIGASAVANLEPQ

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790519, Length=343, Percent_Identity=83.0903790087464, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI87081951, Length=308, Percent_Identity=31.4935064935065, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789637, Length=321, Percent_Identity=27.7258566978193, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788711, Length=352, Percent_Identity=25.5681818181818, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789041, Length=310, Percent_Identity=26.1290322580645, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790012, Length=256, Percent_Identity=30.859375, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790024, Length=259, Percent_Identity=28.1853281853282, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37038; Mature: 37038

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTPKNATRNKLPALILTVAAVVALVYVIWRVDSAPATNDAYASADTVDVVPEVSGRIV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEE
ELAVKDNQLVKQGDLLFRIDPRPYEASLAKAQASLTALDKQIMLTQRSVEAQQLGAAAVK
EEEECCCCCEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSVEKALAIVHQTSKTFQRTESLLAEGYVSDEDVDRARTAHRSAQVDYAALLLQAQSAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHC
GVGGVDALVAQREAVLADIALTKLHLEMATVRAPFDGRVVSLKTSVGQFASAMRPIFTLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECHHHHHHHHHHHHHHHH
DTRHWYVIANFRETELNNIRAGTPATVRLMSDSGKTFEGKVDSIGYGVLPDDGGMVLGGL
CCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCEEEECC
PRVSRSINWVRVAQRFPVKIMVDNPDPEMFRIGASAVANLEPQ
HHHHHCCHHEEHHHHCCEEEEEECCCCCCEEECHHHHCCCCCC
>Mature Secondary Structure
MESTPKNATRNKLPALILTVAAVVALVYVIWRVDSAPATNDAYASADTVDVVPEVSGRIV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEE
ELAVKDNQLVKQGDLLFRIDPRPYEASLAKAQASLTALDKQIMLTQRSVEAQQLGAAAVK
EEEECCCCCEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSVEKALAIVHQTSKTFQRTESLLAEGYVSDEDVDRARTAHRSAQVDYAALLLQAQSAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHC
GVGGVDALVAQREAVLADIALTKLHLEMATVRAPFDGRVVSLKTSVGQFASAMRPIFTLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECHHHHHHHHHHHHHHHH
DTRHWYVIANFRETELNNIRAGTPATVRLMSDSGKTFEGKVDSIGYGVLPDDGGMVLGGL
CCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCEEEECC
PRVSRSINWVRVAQRFPVKIMVDNPDPEMFRIGASAVANLEPQ
HHHHHCCHHEEHHHHCCEEEEEECCCCCCEEECHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]