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The map label for this gene is lldP [H]

Identifier: 218550881

GI number: 218550881

Start: 3686925

End: 3688580

Strand: Direct

Name: lldP [H]

Synonym: EFER_3597

Alternate gene names: 218550881

Gene position: 3686925-3688580 (Clockwise)

Preceding gene: 218550880

Following gene: 218550882

Centisome position: 80.35

GC content: 53.86

Gene sequence:

>1656_bases
ATGAATCTCTGGCAACAAAACTATGATCCGGCTGGCAACATTTGGCTTTCCAGCCTGATCGCATCGCTTCCGATTCTCTT
TTTCTTCTTCGCGCTGATAAAGCTGAAGTTAAAAGGCTATATCGCCGCGTCATGGACGGTGGCTATCGCCCTTGCCGTCG
CCCTGTTGTTCTACAAAATGCCTGTCGCTAATGCGCTGGCCTCGGTGGTGTATGGCTTCTTCTACGGGTTGTGGCCCATC
GCCTGGATTATTATCGCTGCGGTCTTCGTTTATAAAATCTCTGTGAAAACCGGGCAGTTCGACATTATCCGTTCATCAAT
ACTCTCGATAACACCGGATCAACGTCTGCAAATGCTGATTGTCGGTTTCTCCTTCGGCGCATTTCTCGAAGGGGCTGCTG
GCTTTGGCGCACCAGTGGCGATAACCGCCGCTCTGCTGGTCGGACTGGGCTTTAACCCGTTGTATGCTGCTGGTTTGTGT
CTGATCGTCAATACCGCGCCTGTCGCCTTTGGTGCGATGGGTATCCCGATTCTGGTTGCCGGGCAAGTGACCGGGCTGGA
CAGCTTTGAAATCGGCCAGATGGTAGGCCGCCAGCTGCCGTTCCTGACCATTATCGTTCTGTTCTGGATTATGGCGATTA
TGGACGGCTGGCGAGGTGTGAAAGAAACCTGGCCTGCAGTAATGGTCGCTGGCGGTTCGTTTGCTATCGCTCAGTATCTC
AGCTCTAACTTTATCGGCCCGGAACTGCCAGACATCATCTCTTCGCTGGTATCGCTGGTTTGCCTGACACTGTTCCTGAA
ACGCTGGCAGCCAGTGCGTATTTTCCGCTTTGGCGATTTGGGTGCGTCGCAGGTCGATCAGACACTGGCTCGTACCGGAT
ACACCGCAGGGCAAGTTGTTCGCGCCTGGTCACCATTCCTGTTCCTGACAGCAACTGTCACCTTATGGAGTATTCCGCCG
TTCAAAGCGCTGTTTGCACCTGGCGGCGCGTTGTATGACTGGGTGATTAACATTCCGGTTCCGTTCCTCGACAAACTGGT
TGCCCGTATGCCTCCGGTGGTACACGAAGCGACAGCCTACGCTGCGGTGTATAAGTTCGACTGGTTCTCAGCAACGGGTA
CTGCCATTTTGTTTGCCGCCCTGCTCTCTATTGTCTGGCTGAAAATGAAACCCTCAGCGGCTATCCAGACTTTTGGCAGC
ACGCTGAAAGAGTTGGCGCTGCCGATTTACTCCATCGGCATGGTGCTGGCGTTCGCCTTTATCTCTAACTATTCGGGACT
TTCTTCAACGCTGGCTCTGGCTCTGGCGCATACCGGAAGCGCATTTACTTTCTTCTCGCCGTTCCTTGGCTGGCTGGGGG
TATTCCTGACCGGATCAGATACATCATCAAACGCCCTGTTTGCTGCCTTACAGGCTACCGCAGCCCAGCAAATCGGCGTC
TCGGATGTTCTGATGGTGGCAGCTAACACCACAGGCGGAGTTACCGGAAAAATGATCTCCCCACAGTCTATCGCTATCGC
CTGCGCCGCGGTTGGCCTTGTTGGCAAGGAGTCAGACCTGTTCCGCTTTACCGTCAAACACAGCCTGATATTCACCTGCA
TGGTCGGCGTGATCACCACGCTTCAGGCCTATGTTTTAACCTGGATGATCCCGTAA

Upstream 100 bases:

>100_bases
CCTACAATACAATATTGGCAGGGCCACTTTTACACATAGTGTGACGAAGAAGTGAGCACAGACTCATTGCACTATGCGCA
CGGCCCTCAGGAGACCTGCA

Downstream 100 bases:

>100_bases
TGATTGTTATACCCAGACGCCTGTCAGACGAGGTCGCCTCTCGTGTGCGAGCGCTGATTGAAGAGCAGCAACTGGAAGCG
GGTATGAAATTACCCGCCGA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVAGGSFAIAQYL
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGASQVDQTLARTGYTAGQVVRAWSPFLFLTATVTLWSIPP
FKALFAPGGALYDWVINIPVPFLDKLVARMPPVVHEATAYAAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Sequences:

>Translated_551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVAGGSFAIAQYL
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGASQVDQTLARTGYTAGQVVRAWSPFLFLTATVTLWSIPP
FKALFAPGGALYDWVINIPVPFLDKLVARMPPVVHEATAYAAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP
>Mature_551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVAGGSFAIAQYL
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGASQVDQTLARTGYTAGQVVRAWSPFLFLTATVTLWSIPP
FKALFAPGGALYDWVINIPVPFLDKLVARMPPVVHEATAYAAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=95.6442831215971, Blast_Score=1020, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=63.0824372759857, Blast_Score=685, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59156; Mature: 59156

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAASWTVAIALAVALLFYKM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCHHEEEEE
VGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVA
EEEHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCHHEEECCCHHHCCCCCCEEEE
GQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVAGGSFAIAQYL
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCHHHHHHHH
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGASQVDQTLARTGYTAGQVV
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHH
RAWSPFLFLTATVTLWSIPPFKALFAPGGALYDWVINIPVPFLDKLVARMPPVVHEATAY
HHHCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHEECCHHHHHHHHHHCCCHHHHHHHH
AAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGSTLKELALPIYSIGMVLAFAF
HHHEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCC
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITT
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHH
LQAYVLTWMIP
HHHHHHHHCCC
>Mature Secondary Structure
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAASWTVAIALAVALLFYKM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCHHEEEEE
VGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVA
EEEHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCHHEEECCCHHHCCCCCCEEEE
GQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVAGGSFAIAQYL
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCHHHHHHHH
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGASQVDQTLARTGYTAGQVV
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHH
RAWSPFLFLTATVTLWSIPPFKALFAPGGALYDWVINIPVPFLDKLVARMPPVVHEATAY
HHHCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHEECCHHHHHHHHHHCCCHHHHHHHH
AAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGSTLKELALPIYSIGMVLAFAF
HHHEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCC
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITT
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHH
LQAYVLTWMIP
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]