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The map label for this gene is hdeA [H]

Identifier: 218550343

GI number: 218550343

Start: 3106580

End: 3106963

Strand: Reverse

Name: hdeA [H]

Synonym: EFER_3035

Alternate gene names: 218550343

Gene position: 3106963-3106580 (Counterclockwise)

Preceding gene: 218550348

Following gene: 218550342

Centisome position: 67.71

GC content: 41.41

Gene sequence:

>384_bases
ATGTCGAATTGGTTACAGATGGCTCTTCTACTTTTTAATGAGGATATTACGATGAAAAAAGCAATTAGCATTCTTCTTGG
TGGTCTACTCCTGATGCCGGTAATCAGCAATGCCGCAGAAACCCAAAAAGCAGCTGATAACCAAAAACCGGTTAATAGCT
GGACATGTGAAGACTTCCTGGCTCTGGATGCTACTTTCCAACCAACTGCTGTTGGTTTTGCTGAAGCGCTGAACAAAAAA
GATAAGCCTGAAGATGCTGTAATGGATGTTCAGGGTATCGAAACTGTAACACCTGCTATCGTTCAGGCATGTACTCAGGA
CAAAAAAGCCAGCTTTAAAGAAAAAGCACAAGGTGAATGGGCAAAAATTAAGAAAGATCTCTGA

Upstream 100 bases:

>100_bases
TACTTAGTATATTATTATTGCTTTGAAAAATAAGGATTTTTATATTTTGTTGGTATTGCCATCAACATGACAGTCTGCAG
ATTCCAGGTTATAACTCGTA

Downstream 100 bases:

>100_bases
TTTAGCCGGAATTAATAATGGTATTTCGACAGGAGGAGCATCCATGCATATTATGGATACCCTCTTGCCTGGACGTCATT
CTTGAACGGATAGGTAACGA

Product: acid-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MSNWLQMALLLFNEDITMKKAISILLGGLLLMPVISNAAETQKAADNQKPVNSWTCEDFLALDATFQPTAVGFAEALNKK
DKPEDAVMDVQGIETVTPAIVQACTQDKKASFKEKAQGEWAKIKKDL

Sequences:

>Translated_127_residues
MSNWLQMALLLFNEDITMKKAISILLGGLLLMPVISNAAETQKAADNQKPVNSWTCEDFLALDATFQPTAVGFAEALNKK
DKPEDAVMDVQGIETVTPAIVQACTQDKKASFKEKAQGEWAKIKKDL
>Mature_126_residues
SNWLQMALLLFNEDITMKKAISILLGGLLLMPVISNAAETQKAADNQKPVNSWTCEDFLALDATFQPTAVGFAEALNKKD
KPEDAVMDVQGIETVTPAIVQACTQDKKASFKEKAQGEWAKIKKDL

Specific function: Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hdeA family [H]

Homologues:

Organism=Escherichia coli, GI1789926, Length=110, Percent_Identity=79.0909090909091, Blast_Score=160, Evalue=2e-41,

Paralogues:

None

Copy number: 8460 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1060 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5460 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 1020 Molecules/Cell In: Early St

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010486
- ProDom:   PD065392 [H]

Pfam domain/function: PF06411 HdeA [H]

EC number: NA

Molecular weight: Translated: 13928; Mature: 13797

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWLQMALLLFNEDITMKKAISILLGGLLLMPVISNAAETQKAADNQKPVNSWTCEDFL
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ALDATFQPTAVGFAEALNKKDKPEDAVMDVQGIETVTPAIVQACTQDKKASFKEKAQGEW
HHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
AKIKKDL
HHHHCCC
>Mature Secondary Structure 
SNWLQMALLLFNEDITMKKAISILLGGLLLMPVISNAAETQKAADNQKPVNSWTCEDFL
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ALDATFQPTAVGFAEALNKKDKPEDAVMDVQGIETVTPAIVQACTQDKKASFKEKAQGEW
HHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
AKIKKDL
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]