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The map label for this gene is aer [H]

Identifier: 218550332

GI number: 218550332

Start: 3093662

End: 3095182

Strand: Reverse

Name: aer [H]

Synonym: EFER_3024

Alternate gene names: 218550332

Gene position: 3095182-3093662 (Counterclockwise)

Preceding gene: 218550335

Following gene: 218550330

Centisome position: 67.45

GC content: 52.47

Gene sequence:

>1521_bases
ATGTCTTCACCTTTGTATGTTACCCAGCAAAATACCCCGCTGGCTGACGATACTACCCTGATGTCCACCACTGATCTGCA
AAGCTATATCACCCACGCCAACGACACATTTGTTCAGGTGAGCGGCTATTCGCTCAATGAGCTGCTGGCCCAACCGCATA
ATATGGTGCGACACCCGGATATGCCAAAAGCGGCGTTTGCAGATATGTGGTACACCCTGCAACAAGGTGAACCGTGGAGC
GGCATTGTTAAAAATCGGCGCAAAAATGGCGATCACTACTGGGTACGCGCTAACGCAGTGCCGATGGTGCGTAATGGCAA
AATCAGCGGTTACATGTCGATTCGCACCCGGGCAACGGATGAAGAGATTGCCGCAGTGGAGCCGTTGTATCAGGCATTGA
ATGCCGGGCGCAGCAATAAACGAATCCACAAAGGTCTTGTGGTGCGTAAGGGCTGGCTGGGAAAACTGCCTTCGATGCCG
TTACGCTGGCGGACGCGAAGCATGATGGCGCTACTGTTTATTGCCCTTTGTGCAATGCTGCACTTTTCCGTTGTGCCAGT
TAGCGCTTATCTGGCTTGTGCTCTGGTAATGTTTCTTGGAACTCTATGTTTTGAATGGCAACTCGTTCGCCCGATGGAAA
ATGTCGCCAGGCAGGCGCTAAAGGTAGCTACCGGTGAGCAAAATAGTGTTGAGCATTTGCAACGTAGTGATGAGTTGGGA
CTGACACTACGGGCAATAGGGCAGCTTGGCCTGATGTGTCGCTGGCTCATCAATGATGTTTCCAGTCAGGTATCCAGTGT
GCACCACGGTAGTGAAACGCTGGTAAAAGGTAGCGATGAACTGAATGAGCATACTCAGCAAACCGTGGATAACGTTCAGC
AAACGGTGGCGACGATGAAGCAGATGACGGCATCGGTAAAACAGAACTCAGCCACTGCTTCTGCTGCTGACAAGCTCTCT
ATTACTGCCAGTAACGCCGCGCAACAGGGCGGGGAAGCTATGGAGACGGTGATCAAAACGATGGATGATATTGCAGACAG
CACTCAGCGTATTGGCACTATCACCTCACTGATTAACGATATTGCTTTTCAGACCAATATTCTTGCGCTGAATGCAGCGG
TAGAAGCAGCACGCGCAGGTGAACAAGGGAAAGGGTTTGCGGTGGTTGCCGGAGAAGTTCGCCACCTGGCCAGCCGCAGT
GCCAGTGCCGCCAATGATATTCGAAAGTTGATAGATGCCAGTGCCGATAAAGTGCATTCTGGCTCACAGCAGGTTCATGC
TGCCGGGCGCACTATGGACGATATTGTGGCACAGGTGCAAAACGTCACCCGATTAATTGCCCAGATTAGCCATTCAACTC
TGGAACAGGCCGATGGGCTGACCAGCCTGACACGTGCCGTGGATGAGCTAAACCGGATCACCCATAAGAACGCCGAACTG
GTGGAGGAGAGCGCGCAAGTCTCGGCGATGGTGAAACACCGCGCCAGTCGGCTGGCCGACGCGGTAACAGTGTTACATTA
A

Upstream 100 bases:

>100_bases
CGATCTCTATCAAATTTAACAACTAAAGATAAATTTATTAGCGCCGAAATAACATATGACGAAAAGTTAACAACCATAAA
AACCTGCACAGGACGCGATT

Downstream 100 bases:

>100_bases
CTGGTGATATTGGCAGCCAGATATGGCCGTTGGTATAGCCGGATAGAGCAATTGCCGTATCCGGCAATTGGCGATTAATC
CAGCTGGGTAATATCAAAAG

Product: bifunctional signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSSPLYVTQQNTPLADDTTLMSTTDLQSYITHANDTFVQVSGYSLNELLAQPHNMVRHPDMPKAAFADMWYTLQQGEPWS
GIVKNRRKNGDHYWVRANAVPMVRNGKISGYMSIRTRATDEEIAAVEPLYQALNAGRSNKRIHKGLVVRKGWLGKLPSMP
LRWRTRSMMALLFIALCAMLHFSVVPVSAYLACALVMFLGTLCFEWQLVRPMENVARQALKVATGEQNSVEHLQRSDELG
LTLRAIGQLGLMCRWLINDVSSQVSSVHHGSETLVKGSDELNEHTQQTVDNVQQTVATMKQMTASVKQNSATASAADKLS
ITASNAAQQGGEAMETVIKTMDDIADSTQRIGTITSLINDIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRHLASRS
ASAANDIRKLIDASADKVHSGSQQVHAAGRTMDDIVAQVQNVTRLIAQISHSTLEQADGLTSLTRAVDELNRITHKNAEL
VEESAQVSAMVKHRASRLADAVTVLH

Sequences:

>Translated_506_residues
MSSPLYVTQQNTPLADDTTLMSTTDLQSYITHANDTFVQVSGYSLNELLAQPHNMVRHPDMPKAAFADMWYTLQQGEPWS
GIVKNRRKNGDHYWVRANAVPMVRNGKISGYMSIRTRATDEEIAAVEPLYQALNAGRSNKRIHKGLVVRKGWLGKLPSMP
LRWRTRSMMALLFIALCAMLHFSVVPVSAYLACALVMFLGTLCFEWQLVRPMENVARQALKVATGEQNSVEHLQRSDELG
LTLRAIGQLGLMCRWLINDVSSQVSSVHHGSETLVKGSDELNEHTQQTVDNVQQTVATMKQMTASVKQNSATASAADKLS
ITASNAAQQGGEAMETVIKTMDDIADSTQRIGTITSLINDIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRHLASRS
ASAANDIRKLIDASADKVHSGSQQVHAAGRTMDDIVAQVQNVTRLIAQISHSTLEQADGLTSLTRAVDELNRITHKNAEL
VEESAQVSAMVKHRASRLADAVTVLH
>Mature_505_residues
SSPLYVTQQNTPLADDTTLMSTTDLQSYITHANDTFVQVSGYSLNELLAQPHNMVRHPDMPKAAFADMWYTLQQGEPWSG
IVKNRRKNGDHYWVRANAVPMVRNGKISGYMSIRTRATDEEIAAVEPLYQALNAGRSNKRIHKGLVVRKGWLGKLPSMPL
RWRTRSMMALLFIALCAMLHFSVVPVSAYLACALVMFLGTLCFEWQLVRPMENVARQALKVATGEQNSVEHLQRSDELGL
TLRAIGQLGLMCRWLINDVSSQVSSVHHGSETLVKGSDELNEHTQQTVDNVQQTVATMKQMTASVKQNSATASAADKLSI
TASNAAQQGGEAMETVIKTMDDIADSTQRIGTITSLINDIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRHLASRSA
SAANDIRKLIDASADKVHSGSQQVHAAGRTMDDIVAQVQNVTRLIAQISHSTLEQADGLTSLTRAVDELNRITHKNAELV
EESAQVSAMVKHRASRLADAVTVLH

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=506, Percent_Identity=88.7351778656126, Blast_Score=928, Evalue=0.0,
Organism=Escherichia coli, GI1787690, Length=316, Percent_Identity=40.8227848101266, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI2367378, Length=323, Percent_Identity=41.4860681114551, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1788195, Length=299, Percent_Identity=41.4715719063545, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1788194, Length=346, Percent_Identity=37.2832369942197, Blast_Score=208, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 55259; Mature: 55127

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPLYVTQQNTPLADDTTLMSTTDLQSYITHANDTFVQVSGYSLNELLAQPHNMVRHPD
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCHHHHHCCCC
MPKAAFADMWYTLQQGEPWSGIVKNRRKNGDHYWVRANAVPMVRNGKISGYMSIRTRATD
CCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCEEECCCCCEEEEEEECCCC
EEIAAVEPLYQALNAGRSNKRIHKGLVVRKGWLGKLPSMPLRWRTRSMMALLFIALCAML
HHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HFSVVPVSAYLACALVMFLGTLCFEWQLVRPMENVARQALKVATGEQNSVEHLQRSDELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LTLRAIGQLGLMCRWLINDVSSQVSSVHHGSETLVKGSDELNEHTQQTVDNVQQTVATMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
QMTASVKQNSATASAADKLSITASNAAQQGGEAMETVIKTMDDIADSTQRIGTITSLIND
HHHHHHHHCCCHHHHHHHEEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRHLASRSASAANDIRKLIDASADKVHS
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCC
GSQQVHAAGRTMDDIVAQVQNVTRLIAQISHSTLEQADGLTSLTRAVDELNRITHKNAEL
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHH
VEESAQVSAMVKHRASRLADAVTVLH
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSPLYVTQQNTPLADDTTLMSTTDLQSYITHANDTFVQVSGYSLNELLAQPHNMVRHPD
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCHHHHHCCCC
MPKAAFADMWYTLQQGEPWSGIVKNRRKNGDHYWVRANAVPMVRNGKISGYMSIRTRATD
CCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCEEECCCCCEEEEEEECCCC
EEIAAVEPLYQALNAGRSNKRIHKGLVVRKGWLGKLPSMPLRWRTRSMMALLFIALCAML
HHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HFSVVPVSAYLACALVMFLGTLCFEWQLVRPMENVARQALKVATGEQNSVEHLQRSDELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LTLRAIGQLGLMCRWLINDVSSQVSSVHHGSETLVKGSDELNEHTQQTVDNVQQTVATMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
QMTASVKQNSATASAADKLSITASNAAQQGGEAMETVIKTMDDIADSTQRIGTITSLIND
HHHHHHHHCCCHHHHHHHEEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRHLASRSASAANDIRKLIDASADKVHS
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCC
GSQQVHAAGRTMDDIVAQVQNVTRLIAQISHSTLEQADGLTSLTRAVDELNRITHKNAEL
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHH
VEESAQVSAMVKHRASRLADAVTVLH
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]