Click here to switch to the map view.

The map label for this gene is trxB [H]

Identifier: 218550329

GI number: 218550329

Start: 3089805

End: 3091100

Strand: Reverse

Name: trxB [H]

Synonym: EFER_3021

Alternate gene names: 218550329

Gene position: 3091100-3089805 (Counterclockwise)

Preceding gene: 218550330

Following gene: 218550328

Centisome position: 67.36

GC content: 48.3

Gene sequence:

>1296_bases
ATGGGCAGGAATATGCTGCGTCCGTTATTAGCTTTCATCCCTGAAGGGGAAAATATGATAAATAATGATGAATATGACGT
AATCATTGTTGGCGGTGGTCCTGGCGGATTAAGCGCTGCACTGTATGCCGCCAGAGCCAGATTAAAAACGCTGGTCGTGG
AAGAAAAGCTGAAACCTGGCGGGCAATGTGCCACCACTTCGGAACTGGAAAATTATCCGGGGATCATTAAAGACAGTGGT
CCGGCTTTGATGGAAAAGTTTACTGAACACGCCCGTCATTTTGGCGCAGAGTTTTTGCAAGGACGGGTGTTATCACTGGC
TATGAGTCCAGATGGATTACATAAAAGGTTGAAGCTTAAAGATGGCACTACACTCGCGACAAAAAGTGTGATTATTGCCA
CCGGTACACGTCCCCGTATTTTGGGTATTCCTGGTGAAAAAGAGTTTGCCGGACGCGGCGTTTCTTATTGCGCTACCTGC
GATGCAGATTTTTATACCGAACTGGATGTGGTCGTGGTGGGATCAGGAAATACTGCTGTTGAGGAATCCATTTTTCTGAC
ACGTTACGTTAACTCCGTCACCATGGTTGTTATTCATGATGAAGGTCATCTCGATGCCGACCGCATCGCCCGCGAACAAG
CATTTGCCAACGAAAAAATCCGTTTTATCTGGAACAGCACGGTAGCCGCAATTACGGGTGATGAACTGGTTGATGGCGTT
GAGATCATGAACGTCAAAACTGGTGAGCGTTCGCGCATAAATACCAATGGGGTGTTTATGTTCGTTGGCACCGTACCGCA
GACCGACTGGCTGACACCAATAAAAGCACAACTTCCCTTGTCTGACAGCGGCTATATCGAAACTAACCCCCAGCAGGAAA
CGCAACTGCCCGGCGTATTTGCCGTGGGCGATGTGTGCCATAAATTTCTTCGTCAGGTCGTCACTGCCGCCGGAGATGGC
GCGGTTGCAGCTGTTGCCGCCAGCCACTATCTCGAACAAGAAGCCTTCTGGCAGCAACATGTACTCAATAGTGAGTTTAA
AAACATGGTGCTGTTCTGGTCGCCGGTCCAGCCAGAGAGTGTGGAGCTATTAACTCAACTCGAACAGCAAATTGCCCATT
ATGAAGACTGGCGCTTCGTGCCTGTAGATAGTTATAAAAATCAACGGCTTGCTAAACGTTATGGCATAACAGAATTGCCT
ACGTTGCTGTGCCTTGAGCATGGTGGCGAAATGTGCCGAATGACTAAACCTGCATTTAACTCAATTGATCTCGTCCTGGA
GGAACTCACCGTATGA

Upstream 100 bases:

>100_bases
CTCCTGCCTTTTGCTGCGTGCAGCAAAGTCTTTAGTTATATTCTGGTATTTTTAATAAATATCCCATATCACCTCTGTTT
ATTCTCGTCGGTATGCCGGT

Downstream 100 bases:

>100_bases
AGGAACTGAATAAAGATAATTTTGACGATGCAATCGCCAGTGGTGTGGTGTTGGTTGATTTCTGGAGCGAAAGCTGTGAA
CGCTGCAAAGAGTTAATGCC

Product: Thioredoxin-disulfide reductase

Products: NA

Alternate protein names: TRXR; General stress protein 35; GSP35 [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MGRNMLRPLLAFIPEGENMINNDEYDVIIVGGGPGGLSAALYAARARLKTLVVEEKLKPGGQCATTSELENYPGIIKDSG
PALMEKFTEHARHFGAEFLQGRVLSLAMSPDGLHKRLKLKDGTTLATKSVIIATGTRPRILGIPGEKEFAGRGVSYCATC
DADFYTELDVVVVGSGNTAVEESIFLTRYVNSVTMVVIHDEGHLDADRIAREQAFANEKIRFIWNSTVAAITGDELVDGV
EIMNVKTGERSRINTNGVFMFVGTVPQTDWLTPIKAQLPLSDSGYIETNPQQETQLPGVFAVGDVCHKFLRQVVTAAGDG
AVAAVAASHYLEQEAFWQQHVLNSEFKNMVLFWSPVQPESVELLTQLEQQIAHYEDWRFVPVDSYKNQRLAKRYGITELP
TLLCLEHGGEMCRMTKPAFNSIDLVLEELTV

Sequences:

>Translated_431_residues
MGRNMLRPLLAFIPEGENMINNDEYDVIIVGGGPGGLSAALYAARARLKTLVVEEKLKPGGQCATTSELENYPGIIKDSG
PALMEKFTEHARHFGAEFLQGRVLSLAMSPDGLHKRLKLKDGTTLATKSVIIATGTRPRILGIPGEKEFAGRGVSYCATC
DADFYTELDVVVVGSGNTAVEESIFLTRYVNSVTMVVIHDEGHLDADRIAREQAFANEKIRFIWNSTVAAITGDELVDGV
EIMNVKTGERSRINTNGVFMFVGTVPQTDWLTPIKAQLPLSDSGYIETNPQQETQLPGVFAVGDVCHKFLRQVVTAAGDG
AVAAVAASHYLEQEAFWQQHVLNSEFKNMVLFWSPVQPESVELLTQLEQQIAHYEDWRFVPVDSYKNQRLAKRYGITELP
TLLCLEHGGEMCRMTKPAFNSIDLVLEELTV
>Mature_430_residues
GRNMLRPLLAFIPEGENMINNDEYDVIIVGGGPGGLSAALYAARARLKTLVVEEKLKPGGQCATTSELENYPGIIKDSGP
ALMEKFTEHARHFGAEFLQGRVLSLAMSPDGLHKRLKLKDGTTLATKSVIIATGTRPRILGIPGEKEFAGRGVSYCATCD
ADFYTELDVVVVGSGNTAVEESIFLTRYVNSVTMVVIHDEGHLDADRIAREQAFANEKIRFIWNSTVAAITGDELVDGVE
IMNVKTGERSRINTNGVFMFVGTVPQTDWLTPIKAQLPLSDSGYIETNPQQETQLPGVFAVGDVCHKFLRQVVTAAGDGA
VAAVAASHYLEQEAFWQQHVLNSEFKNMVLFWSPVQPESVELLTQLEQQIAHYEDWRFVPVDSYKNQRLAKRYGITELPT
LLCLEHGGEMCRMTKPAFNSIDLVLEELTV

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=297, Percent_Identity=26.5993265993266, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI65787454, Length=297, Percent_Identity=26.5993265993266, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI226437568, Length=297, Percent_Identity=26.5993265993266, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787114, Length=318, Percent_Identity=36.4779874213836, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI87081763, Length=340, Percent_Identity=31.4705882352941, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6320560, Length=327, Percent_Identity=34.5565749235474, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6321898, Length=321, Percent_Identity=33.3333333333333, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 47494; Mature: 47363

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRNMLRPLLAFIPEGENMINNDEYDVIIVGGGPGGLSAALYAARARLKTLVVEEKLKPG
CCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GQCATTSELENYPGIIKDSGPALMEKFTEHARHFGAEFLQGRVLSLAMSPDGLHKRLKLK
CCCCCHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHEEEEC
DGTTLATKSVIIATGTRPRILGIPGEKEFAGRGVSYCATCDADFYTELDVVVVGSGNTAV
CCCEEEECEEEEEECCCCEEEECCCCHHHCCCCCCEEEECCCCCEEEEEEEEECCCCCHH
EESIFLTRYVNSVTMVVIHDEGHLDADRIAREQAFANEKIRFIWNSTVAAITGDELVDGV
HHHHHHHEECCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHCCE
EIMNVKTGERSRINTNGVFMFVGTVPQTDWLTPIKAQLPLSDSGYIETNPQQETQLPGVF
EEEEECCCCCCEECCCCEEEEEECCCCCCCCCCCEEECCCCCCCCEECCCCHHHCCCCEE
AVGDVCHKFLRQVVTAAGDGAVAAVAASHYLEQEAFWQQHVLNSEFKNMVLFWSPVQPES
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHH
VELLTQLEQQIAHYEDWRFVPVDSYKNQRLAKRYGITELPTLLCLEHGGEMCRMTKPAFN
HHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCC
SIDLVLEELTV
HHHHHHHHHCC
>Mature Secondary Structure 
GRNMLRPLLAFIPEGENMINNDEYDVIIVGGGPGGLSAALYAARARLKTLVVEEKLKPG
CHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GQCATTSELENYPGIIKDSGPALMEKFTEHARHFGAEFLQGRVLSLAMSPDGLHKRLKLK
CCCCCHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHEEEEC
DGTTLATKSVIIATGTRPRILGIPGEKEFAGRGVSYCATCDADFYTELDVVVVGSGNTAV
CCCEEEECEEEEEECCCCEEEECCCCHHHCCCCCCEEEECCCCCEEEEEEEEECCCCCHH
EESIFLTRYVNSVTMVVIHDEGHLDADRIAREQAFANEKIRFIWNSTVAAITGDELVDGV
HHHHHHHEECCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHCCE
EIMNVKTGERSRINTNGVFMFVGTVPQTDWLTPIKAQLPLSDSGYIETNPQQETQLPGVF
EEEEECCCCCCEECCCCEEEEEECCCCCCCCCCCEEECCCCCCCCEECCCCHHHCCCCEE
AVGDVCHKFLRQVVTAAGDGAVAAVAASHYLEQEAFWQQHVLNSEFKNMVLFWSPVQPES
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHH
VELLTQLEQQIAHYEDWRFVPVDSYKNQRLAKRYGITELPTLLCLEHGGEMCRMTKPAFN
HHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCC
SIDLVLEELTV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]