Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 218549941

GI number: 218549941

Start: 2696062

End: 2697357

Strand: Reverse

Name: phoR [H]

Synonym: EFER_2626

Alternate gene names: 218549941

Gene position: 2697357-2696062 (Counterclockwise)

Preceding gene: 218549942

Following gene: 218549939

Centisome position: 58.78

GC content: 49.07

Gene sequence:

>1296_bases
GTGCTTGAACGGCTGTCATGGAAAAGGCTGGTTCTGGAACTGATACTTTGCTGTATCCCTGCCTTTATCCTGAGTATTTT
TTTTGGTCATCTGCCCTGGTTTTTGCTGGCATCAGTCACAGGATTGCTTATCTGGCATTTCTGGAACTTACTACGCCTCT
CCTGGTGGCTTTGGGTAGACAGAAGTATGACGCCACCACCAGGGCGCGGGAGCTGGGAGCCATTGCTGTATGGCATCCAT
CAAATGCAATTACGCAATAAAAAACGCCGCCGTGAATTGGGTAATTTAATCAAACGTTTTCGAAGTGGCGCAGAGTCTCT
GCCAGATGCCGTTATTCTGACGACCGAAGAAGGGGGGATTTTCTGGTGTAACGGCCTTGCTCAGCAGTTGTTGGGGCTAC
GCTGGCCTGATGACAGTGGCCAGAACATCCTCAACTTATTGCGCTACCCGGAGTTTGCCCATTATCTAAAAAGCCGCGAT
TTTTCACGACCAATTAATTTGGTATTGAACAATGGTCGTCATCTTGAGATTCGCGTGATGCCTTATACTGATCGGCAACT
GCTGATGGTGGCGCGAGATGTTACTCAAATGCACCAGCTTGAAGGAGCCAGACGGAACTTTTTTGCTAACGTAAGCCATG
AGCTGCGCACGCCGCTTACGGTCTTACAAGGCTATCTGGAAATGATGCATGAACAGCCGCTGGAAGGTGCGACGCGAGAA
AAAGCGCTTCATACTATGCGTGAACAAACACACCGTATGGAAGGCTTGGTGAAACAGCTGCTTACGCTGTCAAAAATTGA
AGCTGCCCCGGTGCTGGCACTGAATGAACAAGTCGATGTGCCGATGATGCTACGAGTAGTGGAGCGGGAAGCTCAAACAC
TGAGCCAGAATAAACACAAAATTACATTTGATATCGACAATCAAATTAAAGTGTTGGGCAATGAAGATCAGCTGCGCAGT
GCCATTTCGAATCTGGTCTATAACGCAGTTAATCACACGCCAGAAGGTACGAAGATTGCTGTACGCTGGCAGCGCGTGGC
ACATGGTGTGGAGTTTAGTGTGGAAGATAATGGTCCTGGAATTACCGCCGAACACCTTCCGCGTCTCACTGAGCGCTTCT
ATCGTGTGGATAAAGCGCGTTCGCGACAGACAGGGGGCAGTGGCCTCGGTCTGGCGATTGTAAAGCACGCGCTCAATCAC
CACGAAAGCCGATTACATATTGAAAGCACACCTGGCGTTGGCACTCGGTTTAGCTTTGTATTACCGGAACGTTTAATTGC
CAAAAATAGCGCTTAA

Upstream 100 bases:

>100_bases
ACAGTGCGAGGAACAGGGTATCGTTTTTCGACCCGCTTTTGACGCCTCACCCGCCGTAATGGCGGGTGAGGCTTTCTATA
GAGTAAATGGAGTATGACGC

Downstream 100 bases:

>100_bases
CAGACCGTTGTCAGATTATCTTTCCATAAGCCAGCTAATGCTGGCTTATTTTCTTTGCGTCTTTTCCCCTTGCGGTGAAT
TTTCCGACGTCTGATGATTT

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLERLSWKRLVLELILCCIPAFILSIFFGHLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGIH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVILTTEEGGIFWCNGLAQQLLGLRWPDDSGQNILNLLRYPEFAHYLKSRD
FSRPINLVLNNGRHLEIRVMPYTDRQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMHEQPLEGATRE
KALHTMREQTHRMEGLVKQLLTLSKIEAAPVLALNEQVDVPMMLRVVEREAQTLSQNKHKITFDIDNQIKVLGNEDQLRS
AISNLVYNAVNHTPEGTKIAVRWQRVAHGVEFSVEDNGPGITAEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNH
HESRLHIESTPGVGTRFSFVLPERLIAKNSA

Sequences:

>Translated_431_residues
MLERLSWKRLVLELILCCIPAFILSIFFGHLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGIH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVILTTEEGGIFWCNGLAQQLLGLRWPDDSGQNILNLLRYPEFAHYLKSRD
FSRPINLVLNNGRHLEIRVMPYTDRQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMHEQPLEGATRE
KALHTMREQTHRMEGLVKQLLTLSKIEAAPVLALNEQVDVPMMLRVVEREAQTLSQNKHKITFDIDNQIKVLGNEDQLRS
AISNLVYNAVNHTPEGTKIAVRWQRVAHGVEFSVEDNGPGITAEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNH
HESRLHIESTPGVGTRFSFVLPERLIAKNSA
>Mature_431_residues
MLERLSWKRLVLELILCCIPAFILSIFFGHLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGIH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVILTTEEGGIFWCNGLAQQLLGLRWPDDSGQNILNLLRYPEFAHYLKSRD
FSRPINLVLNNGRHLEIRVMPYTDRQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMHEQPLEGATRE
KALHTMREQTHRMEGLVKQLLTLSKIEAAPVLALNEQVDVPMMLRVVEREAQTLSQNKHKITFDIDNQIKVLGNEDQLRS
AISNLVYNAVNHTPEGTKIAVRWQRVAHGVEFSVEDNGPGITAEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNH
HESRLHIESTPGVGTRFSFVLPERLIAKNSA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=430, Percent_Identity=89.7674418604651, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI1786783, Length=269, Percent_Identity=31.9702602230483, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=30, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=30, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=27.5109170305677, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994928, Length=355, Percent_Identity=26.4788732394366, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=29.6296296296296, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789403, Length=254, Percent_Identity=30.3149606299213, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=325, Percent_Identity=24.9230769230769, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790861, Length=201, Percent_Identity=31.3432835820896, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=24.7747747747748, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=230, Percent_Identity=27.8260869565217, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789808, Length=232, Percent_Identity=29.7413793103448, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787374, Length=251, Percent_Identity=23.9043824701195, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=29.4372294372294, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790300, Length=352, Percent_Identity=26.4204545454545, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=26.1061946902655, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=218, Percent_Identity=28.8990825688073, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=264, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790567, Length=352, Percent_Identity=23.8636363636364, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49599; Mature: 49599

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLSWKRLVLELILCCIPAFILSIFFGHLPWFLLASVTGLLIWHFWNLLRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGIHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVILTTEEGGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQLLGLRWPDDSGQNILNLLRYPEFAHYLKSRDFSRPINLVLNNGRHLEIRVM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHEECCCCEEEEEEE
PYTDRQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMHEQPLEGATRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
KALHTMREQTHRMEGLVKQLLTLSKIEAAPVLALNEQVDVPMMLRVVEREAQTLSQNKHK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCE
ITFDIDNQIKVLGNEDQLRSAISNLVYNAVNHTPEGTKIAVRWQRVAHGVEFSVEDNGPG
EEEEECCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCEEEECCCCCC
ITAEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNHHESRLHIESTPGVGTRFSFV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEHHH
LPERLIAKNSA
HHHHHHHCCCC
>Mature Secondary Structure
MLERLSWKRLVLELILCCIPAFILSIFFGHLPWFLLASVTGLLIWHFWNLLRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGIHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVILTTEEGGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQLLGLRWPDDSGQNILNLLRYPEFAHYLKSRDFSRPINLVLNNGRHLEIRVM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHEECCCCEEEEEEE
PYTDRQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMHEQPLEGATRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
KALHTMREQTHRMEGLVKQLLTLSKIEAAPVLALNEQVDVPMMLRVVEREAQTLSQNKHK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCE
ITFDIDNQIKVLGNEDQLRSAISNLVYNAVNHTPEGTKIAVRWQRVAHGVEFSVEDNGPG
EEEEECCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCEEEECCCCCC
ITAEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNHHESRLHIESTPGVGTRFSFV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEHHH
LPERLIAKNSA
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]