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The map label for this gene is pcp

Identifier: 218549724

GI number: 218549724

Start: 2462026

End: 2462670

Strand: Reverse

Name: pcp

Synonym: EFER_2401

Alternate gene names: 218549724

Gene position: 2462670-2462026 (Counterclockwise)

Preceding gene: 218549725

Following gene: 218549718

Centisome position: 53.67

GC content: 51.63

Gene sequence:

>645_bases
ATGAAAACCGTTTTAATCACCGGTTTTGAACCGTTTGGTGGTGAGCAAATTAATCCTTCATGGGAAGTAGTTTCGCAGCT
CGATAATGCGATTCTTGGTGGCTGTCGGGTGGTGGCACGGCAATTACCGTGTGTGTTTGGTGAGTCGTTAGCGGTGCTGA
ATTCGGCAATTGATGCGCTTTCGCCATCGGTGGTGCTGGCAGTAGGACAGGCTGGTGGACGAACTGATATCACGGTTGAG
CGCGTGGCAATTAACGTTGATGATGCGCGAATCCCGGATAACCGTGGCAACCAGCCGGTTGATGTACCGGTAATCCCTAA
TGGTCCGGCAGCCTGGTTTAGCACTTTACCCATAAAAGCAATGGTTTCAGCGATACGGGAGGCTGGCATTCCGGCTTCTG
TATCCCAGACGGCGGGAACCTTTGTCTGCAATCATGTGATGTACGGGCTATTGCATAAATTAAGTAGCATGGCGGATGTT
AAAGGGGGATTTATTCATATTCCCTACCTGCCTCAACAGGCAGCGGCACACCCAGGAGCGCCGAGCATGGCGGCAGATAC
CGTGCGAAGAGCGCTCGAAACCGCAATTATTACGGCGTTGTATGTCGATGCCGATATTATCGTGGCAGGTGGAGCGACAC
ATTAA

Upstream 100 bases:

>100_bases
TAAAAACGCGGTGATCAAAGTCCAGGTGCCGACCGGCCTGATGCTATTGCTGGTCAATATTTTCCTGATGTATTTCCTGA
TGTTTTTATAAGGGGGCAGG

Downstream 100 bases:

>100_bases
TAACCTGGTGCATTGTGTTGACTATCACTCGCAGCCATACTGCGGCCGGGCATTGTCCTAAGTTGTTCGTTTCGGCGCAT
ATGTTGAGATAAACCGCGCA

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKTVLITGFEPFGGEQINPSWEVVSQLDNAILGGCRVVARQLPCVFGESLAVLNSAIDALSPSVVLAVGQAGGRTDITVE
RVAINVDDARIPDNRGNQPVDVPVIPNGPAAWFSTLPIKAMVSAIREAGIPASVSQTAGTFVCNHVMYGLLHKLSSMADV
KGGFIHIPYLPQQAAAHPGAPSMAADTVRRALETAIITALYVDADIIVAGGATH

Sequences:

>Translated_214_residues
MKTVLITGFEPFGGEQINPSWEVVSQLDNAILGGCRVVARQLPCVFGESLAVLNSAIDALSPSVVLAVGQAGGRTDITVE
RVAINVDDARIPDNRGNQPVDVPVIPNGPAAWFSTLPIKAMVSAIREAGIPASVSQTAGTFVCNHVMYGLLHKLSSMADV
KGGFIHIPYLPQQAAAHPGAPSMAADTVRRALETAIITALYVDADIIVAGGATH
>Mature_214_residues
MKTVLITGFEPFGGEQINPSWEVVSQLDNAILGGCRVVARQLPCVFGESLAVLNSAIDALSPSVVLAVGQAGGRTDITVE
RVAINVDDARIPDNRGNQPVDVPVIPNGPAAWFSTLPIKAMVSAIREAGIPASVSQTAGTFVCNHVMYGLLHKLSSMADV
KGGFIHIPYLPQQAAAHPGAPSMAADTVRRALETAIITALYVDADIIVAGGATH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

Organism=Homo sapiens, GI8923198, Length=202, Percent_Identity=27.7227722772277, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_ESCF3 (B7LKQ5)

Other databases:

- EMBL:   CU928158
- RefSeq:   YP_002383515.1
- MEROPS:   C15.001
- EnsemblBacteria:   EBESCT00000123889
- GeneID:   7124008
- GenomeReviews:   CU928158_GR
- KEGG:   efe:EFER_2401
- HOGENOM:   HBG360405
- ProtClustDB:   PRK13197
- BioCyc:   EFER585054:EFER_2401-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22287; Mature: 22287

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 143-143 ACT_SITE 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLITGFEPFGGEQINPSWEVVSQLDNAILGGCRVVARQLPCVFGESLAVLNSAIDAL
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
SPSVVLAVGQAGGRTDITVERVAINVDDARIPDNRGNQPVDVPVIPNGPAAWFSTLPIKA
CCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCHHH
MVSAIREAGIPASVSQTAGTFVCNHVMYGLLHKLSSMADVKGGFIHIPYLPQQAAAHPGA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCC
PSMAADTVRRALETAIITALYVDADIIVAGGATH
CCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure
MKTVLITGFEPFGGEQINPSWEVVSQLDNAILGGCRVVARQLPCVFGESLAVLNSAIDAL
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
SPSVVLAVGQAGGRTDITVERVAINVDDARIPDNRGNQPVDVPVIPNGPAAWFSTLPIKA
CCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCHHH
MVSAIREAGIPASVSQTAGTFVCNHVMYGLLHKLSSMADVKGGFIHIPYLPQQAAAHPGA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCC
PSMAADTVRRALETAIITALYVDADIIVAGGATH
CCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA