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The map label for this gene is gltT [H]

Identifier: 218549704

GI number: 218549704

Start: 2439360

End: 2440724

Strand: Direct

Name: gltT [H]

Synonym: EFER_2381

Alternate gene names: 218549704

Gene position: 2439360-2440724 (Clockwise)

Preceding gene: 218549703

Following gene: 218549705

Centisome position: 53.16

GC content: 45.64

Gene sequence:

>1365_bases
TTGACGAATCTGAAGTCGCTTCTCAGTCAGGTAATTCGAGACCTCGCTCGCCAACCCTTTATCGAAGGAGTAATAATGAA
GAAAATAAATTTAACCCAAATGATTATATTTGGACTTATTCTCGGCATTATTTCCGGAGAGGTTATTTATAATACAGCGT
CACCGGAGACAGCTAAGGTATACTCGCAAGAAATATCAATATTAACCACGATATTTTTACGTATGATCAAAATGATCATC
GCTCCCCTGGTAATTTCAACACTGGTTGTCGGCATTGCCAAAATGGGCGATGCAAAAACGTTGGGGCGTATATTTACTAA
AACATTTTTCCTGTTCGTCTGCGCCTCATTAATCTCAATCGCGCTTGGTCTTATAACGGTAAATCTTTTTGAACCCGGCA
CTGGTATCAATTTCGTCCCTACTGACACAAGTGTTGTTGCCGCTATTCCCGCTGAACCTTTTACCCTGCGGGCGTTTGTT
TCCCATGCAGTGCCAACCAGCATTGCGGACGCCATGGCACGCAATGAAATTCTGCAAATTGTCATTTTCTCATTGTTTCT
CGGTTGCAGTTTGGGGGCAATAGGTGACAAAGGAACAGCGATGGTCAATGTACTCGATTCACTGGTACATGCCATGCTGA
AACTAACAGGCTATGTGATGTTGTTTGCTCCCCTGACGGTATTTGCTGCTATCTCCGCGCTAATCGCTGAACGGGGTCTC
GGGGTAATGATCAGTACCGGAATATTTATGGGTGAGTTTTACTTCACACTGACCATACTGTGGGTACTACTAATTGGTGT
CACAGCAGCGTTAGTTGGGCCGTGTATCAAACGACTCACCAAAATGCTTATGGAACCAATGCTATTGGCTTTTACGACTT
CCAGTTCCGAAGCGGCATTTCCAGGCACACTGAGTAAACTCGAAGAATTTGGTGTATCGCCTAAAATTGCCAGTTTCGTA
TTGCCCATCGGTTACTCTTTTAACCTTGTAGGATCAATGGCCTACTGTTCATTTGCCACAGTCTTTATTGCCCAGGCCTG
TAATATAAATTTAGGCGCTGGAGAGCAGATTACGATGTTGCTCATCCTGATGTTGACCTCCAAAGGCATGGCCGGCGTAC
CACGCGCCTCGATGGTGGTCATTGCCGCAACGCTTAATCAATTCAATATTCCCGAAGCAGGCCTAATTCTGTTAATGGGA
GTCGATCCTTTCCTCGATATGGGCCGTTCTGCCACTAACGTCATGAGTAATGCCATGGGTGCAGCCATTGTGAGTCGTTG
GGAGGGGGAGCATTTTGGTGTCGGATGTCGGGGGACACCATCAGGTAAAAGCGAGACTGAACTGTCAGAAATGGAGCTAC
CTTAA

Upstream 100 bases:

>100_bases
AGCAACATGCGCCATTATTAAACATTGAATTCGATTTGTAGTTCTCTCCCCTGACGTTAAGTAAATATTTTTAATCCTTA
ACGTCAGGCTATCAACACTG

Downstream 100 bases:

>100_bases
TTCGTTTCGCCTGGCGTCACAATTAACCTAACTTTGCCACCTACTTTTAAGATGAGAAAAAAATGTCTAAGCCCTTTGTC
TGGCAGGAGCTCTTTACGTT

Product: symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTNLKSLLSQVIRDLARQPFIEGVIMKKINLTQMIIFGLILGIISGEVIYNTASPETAKVYSQEISILTTIFLRMIKMII
APLVISTLVVGIAKMGDAKTLGRIFTKTFFLFVCASLISIALGLITVNLFEPGTGINFVPTDTSVVAAIPAEPFTLRAFV
SHAVPTSIADAMARNEILQIVIFSLFLGCSLGAIGDKGTAMVNVLDSLVHAMLKLTGYVMLFAPLTVFAAISALIAERGL
GVMISTGIFMGEFYFTLTILWVLLIGVTAALVGPCIKRLTKMLMEPMLLAFTTSSSEAAFPGTLSKLEEFGVSPKIASFV
LPIGYSFNLVGSMAYCSFATVFIAQACNINLGAGEQITMLLILMLTSKGMAGVPRASMVVIAATLNQFNIPEAGLILLMG
VDPFLDMGRSATNVMSNAMGAAIVSRWEGEHFGVGCRGTPSGKSETELSEMELP

Sequences:

>Translated_454_residues
MTNLKSLLSQVIRDLARQPFIEGVIMKKINLTQMIIFGLILGIISGEVIYNTASPETAKVYSQEISILTTIFLRMIKMII
APLVISTLVVGIAKMGDAKTLGRIFTKTFFLFVCASLISIALGLITVNLFEPGTGINFVPTDTSVVAAIPAEPFTLRAFV
SHAVPTSIADAMARNEILQIVIFSLFLGCSLGAIGDKGTAMVNVLDSLVHAMLKLTGYVMLFAPLTVFAAISALIAERGL
GVMISTGIFMGEFYFTLTILWVLLIGVTAALVGPCIKRLTKMLMEPMLLAFTTSSSEAAFPGTLSKLEEFGVSPKIASFV
LPIGYSFNLVGSMAYCSFATVFIAQACNINLGAGEQITMLLILMLTSKGMAGVPRASMVVIAATLNQFNIPEAGLILLMG
VDPFLDMGRSATNVMSNAMGAAIVSRWEGEHFGVGCRGTPSGKSETELSEMELP
>Mature_453_residues
TNLKSLLSQVIRDLARQPFIEGVIMKKINLTQMIIFGLILGIISGEVIYNTASPETAKVYSQEISILTTIFLRMIKMIIA
PLVISTLVVGIAKMGDAKTLGRIFTKTFFLFVCASLISIALGLITVNLFEPGTGINFVPTDTSVVAAIPAEPFTLRAFVS
HAVPTSIADAMARNEILQIVIFSLFLGCSLGAIGDKGTAMVNVLDSLVHAMLKLTGYVMLFAPLTVFAAISALIAERGLG
VMISTGIFMGEFYFTLTILWVLLIGVTAALVGPCIKRLTKMLMEPMLLAFTTSSSEAAFPGTLSKLEEFGVSPKIASFVL
PIGYSFNLVGSMAYCSFATVFIAQACNINLGAGEQITMLLILMLTSKGMAGVPRASMVVIAATLNQFNIPEAGLILLMGV
DPFLDMGRSATNVMSNAMGAAIVSRWEGEHFGVGCRGTPSGKSETELSEMELP

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=449, Percent_Identity=28.0623608017817, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI21314632, Length=435, Percent_Identity=28.0459770114943, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4827012, Length=287, Percent_Identity=31.7073170731707, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI66773030, Length=444, Percent_Identity=26.3513513513513, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI194239697, Length=266, Percent_Identity=30.0751879699248, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI223468564, Length=293, Percent_Identity=28.6689419795222, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223468566, Length=293, Percent_Identity=28.6689419795222, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI262359914, Length=449, Percent_Identity=24.9443207126949, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI40254478, Length=256, Percent_Identity=28.90625, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI5032093, Length=293, Percent_Identity=28.3276450511945, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI301601644, Length=203, Percent_Identity=31.5270935960591, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=37.378640776699, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1789947, Length=389, Percent_Identity=36.5038560411311, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788024, Length=425, Percent_Identity=27.5294117647059, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17537407, Length=444, Percent_Identity=25.9009009009009, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71996953, Length=467, Percent_Identity=24.4111349036403, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71983106, Length=429, Percent_Identity=25.4079254079254, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=429, Percent_Identity=25.4079254079254, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193206505, Length=446, Percent_Identity=25.7847533632287, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193206654, Length=450, Percent_Identity=24, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17541374, Length=406, Percent_Identity=23.3990147783251, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583025, Length=444, Percent_Identity=27.027027027027, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17137668, Length=444, Percent_Identity=27.027027027027, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24583023, Length=444, Percent_Identity=27.027027027027, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI281360483, Length=423, Percent_Identity=28.6052009456265, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17137666, Length=423, Percent_Identity=28.6052009456265, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281360481, Length=423, Percent_Identity=28.6052009456265, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48419; Mature: 48287

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLKSLLSQVIRDLARQPFIEGVIMKKINLTQMIIFGLILGIISGEVIYNTASPETAKV
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHH
YSQEISILTTIFLRMIKMIIAPLVISTLVVGIAKMGDAKTLGRIFTKTFFLFVCASLISI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALGLITVNLFEPGTGINFVPTDTSVVAAIPAEPFTLRAFVSHAVPTSIADAMARNEILQI
HHHHHHHEEECCCCCCEEECCCCCEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHH
VIFSLFLGCSLGAIGDKGTAMVNVLDSLVHAMLKLTGYVMLFAPLTVFAAISALIAERGL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVMISTGIFMGEFYFTLTILWVLLIGVTAALVGPCIKRLTKMLMEPMLLAFTTSSSEAAF
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
PGTLSKLEEFGVSPKIASFVLPIGYSFNLVGSMAYCSFATVFIAQACNINLGAGEQITML
CHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LILMLTSKGMAGVPRASMVVIAATLNQFNIPEAGLILLMGVDPFLDMGRSATNVMSNAMG
HHHHHHCCCCCCCCCHHHEEEEEHHCCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHH
AAIVSRWEGEHFGVGCRGTPSGKSETELSEMELP
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
TNLKSLLSQVIRDLARQPFIEGVIMKKINLTQMIIFGLILGIISGEVIYNTASPETAKV
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHH
YSQEISILTTIFLRMIKMIIAPLVISTLVVGIAKMGDAKTLGRIFTKTFFLFVCASLISI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALGLITVNLFEPGTGINFVPTDTSVVAAIPAEPFTLRAFVSHAVPTSIADAMARNEILQI
HHHHHHHEEECCCCCCEEECCCCCEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHH
VIFSLFLGCSLGAIGDKGTAMVNVLDSLVHAMLKLTGYVMLFAPLTVFAAISALIAERGL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVMISTGIFMGEFYFTLTILWVLLIGVTAALVGPCIKRLTKMLMEPMLLAFTTSSSEAAF
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
PGTLSKLEEFGVSPKIASFVLPIGYSFNLVGSMAYCSFATVFIAQACNINLGAGEQITML
CHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LILMLTSKGMAGVPRASMVVIAATLNQFNIPEAGLILLMGVDPFLDMGRSATNVMSNAMG
HHHHHHCCCCCCCCCHHHEEEEEHHCCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHH
AAIVSRWEGEHFGVGCRGTPSGKSETELSEMELP
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]