BacMap

Definition	Escherichia fergusonii ATCC 35469 chromosome, complete genome.
Accession	NC_011740
Length	4,588,711

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The map label for this gene is ccmA [H]

Identifier: 218549616

GI number: 218549616

Start: 2349264

End: 2349887

Strand: Reverse

Name: ccmA [H]

Synonym: EFER_2291

Alternate gene names: 218549616

Gene position: 2349887-2349264 (Counterclockwise)

Preceding gene: 218549617

Following gene: 218549615

Centisome position: 51.21

GC content: 56.09

Gene sequence:

>624_bases
GTGGTAATGCTTGAAGCCAGAGGTTTGCTCTGCGAGCGTGATGAACGAACGTTGTTCAGTGATTTATCGTTTTCCCTGAA
AGCAGGGGAGTGGGTGCAGATTACCGGAAGTAACGGTGCGGGGAAGACGACACTTCTCCGCCTGTTGACAGGGTTATCGC
GCCCTGACGCAGGCGAGGTTCTCTGGCAAGGGCAGCCCTTGCATCAGGTACGCGACAGCTACCATCAAAACCTGTTATGG
ATAGGCCATCAGCCGGGGATCAAAACCCGGCTGACGGCGTTGGAAAATCTGCACTTTTATCATCGCGATGGCGATACCGC
ACAATGTCTGGAAGCCCTGGCGCAGGCCGGGCTTGCCGGATTCGAAGATATTCCGGTAAATCAACTTTCTGCCGGGCAAC
AACGCCGCGTCGCTTTAGCGCGTCTGTGGCTGACCCGTGCCACGTTGTGGATACTCGACGAACCTTTTACCGCGATTGAC
GTCAACGGCGTCGATCGTCTGACCCAGCGCATGGCGCAGCATACGGAGCAGGGGGGGATTGTGATTCTGACTACCCACCA
GCCGCTCAACGTTGCTGAAAGTAAAATTCGCCGCATTTCACTGACGCAAACGAGGGCCGCATGA

Upstream 100 bases:

>100_bases
TAAAAGCTGGGCAAACCTGTATCGACTGCCATAAAGGGATTGCACATAAGCTGCCTGATATGCGCGAAGTTGAGCCAGGT
TTCTGACAAGGTAAAGATGA

Downstream 100 bases:

>100_bases
TGTTCTGGCGCATTTTCCGTCTTGAGCTGCGCGTAGCGTTTCGCCATAGCGCCGAAATCGCCAACCCGCTGTGGTTCTTC
CTGATTGTTATTACCCTTTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MVMLEARGLLCERDERTLFSDLSFSLKAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLW
IGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAID
VNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA

Sequences:

>Translated_207_residues
MVMLEARGLLCERDERTLFSDLSFSLKAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLW
IGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAID
VNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA
>Mature_207_residues
MVMLEARGLLCERDERTLFSDLSFSLKAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLW
IGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAID
VNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=201, Percent_Identity=30.3482587064677, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI27436953, Length=202, Percent_Identity=29.7029702970297, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI9665248, Length=194, Percent_Identity=29.8969072164948, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI27477115, Length=203, Percent_Identity=29.5566502463054, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI6005701, Length=208, Percent_Identity=28.8461538461538, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI11967969, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI27881501, Length=175, Percent_Identity=27.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI30795238, Length=175, Percent_Identity=27.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI105990541, Length=171, Percent_Identity=29.2397660818713, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI73747915, Length=161, Percent_Identity=29.1925465838509, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI73747917, Length=161, Percent_Identity=29.1925465838509, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI47078218, Length=182, Percent_Identity=29.1208791208791, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI45446740, Length=182, Percent_Identity=29.1208791208791, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI150417984, Length=186, Percent_Identity=26.8817204301075, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI42741659, Length=192, Percent_Identity=26.0416666666667, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI255708477, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI148612844, Length=192, Percent_Identity=27.0833333333333, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI87082064, Length=207, Percent_Identity=97.5845410628019, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=30.1204819277108, Blast_Score=87, Evalue=5e-19,
Organism=Escherichia coli, GI87081834, Length=212, Percent_Identity=29.2452830188679, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI87081791, Length=191, Percent_Identity=30.3664921465969, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1787041, Length=205, Percent_Identity=29.2682926829268, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1788165, Length=153, Percent_Identity=35.2941176470588, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788225, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787370, Length=154, Percent_Identity=30.5194805194805, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789891, Length=199, Percent_Identity=30.6532663316583, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786703, Length=188, Percent_Identity=30.8510638297872, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI48995001, Length=180, Percent_Identity=28.8888888888889, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI48994943, Length=206, Percent_Identity=28.1553398058252, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788761, Length=197, Percent_Identity=27.4111675126904, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787029, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789991, Length=154, Percent_Identity=31.1688311688312, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI87081782, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1789593, Length=207, Percent_Identity=28.9855072463768, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786698, Length=176, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789032, Length=152, Percent_Identity=28.2894736842105, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788897, Length=204, Percent_Identity=28.4313725490196, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787547, Length=178, Percent_Identity=29.7752808988764, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788210, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787164, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786345, Length=191, Percent_Identity=30.8900523560209, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790544, Length=202, Percent_Identity=27.7227722772277, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790190, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787105, Length=197, Percent_Identity=27.9187817258883, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788450, Length=176, Percent_Identity=27.8409090909091, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786563, Length=196, Percent_Identity=29.5918367346939, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI2367384, Length=168, Percent_Identity=29.7619047619048, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1789873, Length=201, Percent_Identity=25.3731343283582, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI48994997, Length=173, Percent_Identity=31.7919075144509, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790739, Length=180, Percent_Identity=26.1111111111111, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786253, Length=145, Percent_Identity=30.3448275862069, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1786398, Length=188, Percent_Identity=27.1276595744681, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1788506, Length=170, Percent_Identity=28.2352941176471, Blast_Score=60, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=205, Percent_Identity=28.2926829268293, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17511077, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17533971, Length=193, Percent_Identity=25.9067357512953, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25146777, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=192, Percent_Identity=28.125, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=186, Percent_Identity=24.7311827956989, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193211017, Length=186, Percent_Identity=24.7311827956989, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193211015, Length=186, Percent_Identity=24.7311827956989, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=186, Percent_Identity=24.7311827956989, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193202349, Length=186, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646699, Length=186, Percent_Identity=24.1935483870968, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17559834, Length=175, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17543740, Length=195, Percent_Identity=25.1282051282051, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=191, Percent_Identity=27.2251308900524, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=164, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533592, Length=193, Percent_Identity=27.4611398963731, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115535101, Length=193, Percent_Identity=25.9067357512953, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=175, Percent_Identity=26.2857142857143, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=196, Percent_Identity=25.5102040816327, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221500365, Length=181, Percent_Identity=32.5966850828729, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007184, Length=181, Percent_Identity=32.5966850828729, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=25.6830601092896, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=25.6830601092896, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641342, Length=179, Percent_Identity=30.7262569832402, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28574533, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28574744, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666092, Length=190, Percent_Identity=25.7894736842105, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648314, Length=190, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 23082; Mature: 23082

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMLEARGLLCERDERTLFSDLSFSLKAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEV
CEEECCCCCEECCCCHHHHHHCCCEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
LWQGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAG
EECCCCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCC
FEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGI
CCCCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCE
VILTTHQPLNVAESKIRRISLTQTRAA
EEEECCCCCHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MVMLEARGLLCERDERTLFSDLSFSLKAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEV
CEEECCCCCEECCCCHHHHHHCCCEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
LWQGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAG
EECCCCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCC
FEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGI
CCCCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCE
VILTTHQPLNVAESKIRRISLTQTRAA
EEEECCCCCHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]