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The map label for this gene is frmC [H]

Identifier: 218549567

GI number: 218549567

Start: 2296567

End: 2297403

Strand: Direct

Name: frmC [H]

Synonym: EFER_2239

Alternate gene names: 218549567

Gene position: 2296567-2297403 (Clockwise)

Preceding gene: 218549560

Following gene: 218549571

Centisome position: 50.05

GC content: 53.64

Gene sequence:

>837_bases
ATGGAATTGCTCGAAGAGCACCGCTGTTTTGAAGGCTGGCAACAACGCTGGCGGCACGACTCCCGAATCTTAAACTGTGC
GATGACGTTTAGTATCTTTTTGCCACCGCCCCGCGATAACACCCCGCCACCAGTGTTGTACTGGCTTTCAGGGTTAACCT
GCAATGACGAGAACTTCACTACCAAGGCGGGGGCCCAGCGCGTGGCGGCGGAACTGGGGATTGTGCTGGTGATGCCTGAC
ACCAGCCCGCGCGGCGAACAGGTTGCCAACAACGACGGCTACGATTTAGGCCAGGGCGCAGGCTTTTATCTTAATGCCAC
GCAACCACCGTGGGCGACGCACTATCGGATGTATGATTATCTGCGCGATGAATTACCTGAGTTGATTCAGTCGCAATTTA
ACGTCAGCGATCGCTGCGCTATCAGCGGCCATTCGATGGGCGGTCACGGTGCATTGATTATGGCGCTAAAAAACCCAGGC
AAATACGCCAGCGTTTCCGCCTTTGCGCCGATTGTGAATCCATGCAGCGTACCCTGGGGCATTAAAGCGTTTAGCACCTA
TTTAGGTGAGGACAAAAATGCATGGCTGGAATGGGACAGTTGTGCGTTGATGTACGCCAGCAATGCGCAGGATGCAATCC
CGACACTGATTGATCAGGGCGATAACGATCAGTTTCTTGCCGACCAGCTACAACCTGCGGTGCTGGCGGAAGCCGCCCGT
CAAAAAGCATGGCCGATGACACTGCGTATTCAGCCGGGATATGATCACAGTTACTACTTCATCGCCTCTTTTATAGAGGA
TCATCTGCGCTTCCATGCGCAGCATTTACTGAAGTAA

Upstream 100 bases:

>100_bases
TAAAACACGGTTATGTAAATACGGAAGTGAAAGTTACTCACGACACAATGAATTAACGGTATGATGGAGGAATTGCAAAC
AACACAACAAGGAGCCACGC

Downstream 100 bases:

>100_bases
AGTCTGCCCGGTTCGCCGGGCATCTTCTCATCAGAAGCGATAATCCACAGCCATAAAGTAACGACGTCCATCTTCGTTAT
AGCTGTAGTCGTCACGACTG

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MELLEEHRCFEGWQQRWRHDSRILNCAMTFSIFLPPPRDNTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPD
TSPRGEQVANNDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPELIQSQFNVSDRCAISGHSMGGHGALIMALKNPG
KYASVSAFAPIVNPCSVPWGIKAFSTYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQHLLK

Sequences:

>Translated_278_residues
MELLEEHRCFEGWQQRWRHDSRILNCAMTFSIFLPPPRDNTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPD
TSPRGEQVANNDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPELIQSQFNVSDRCAISGHSMGGHGALIMALKNPG
KYASVSAFAPIVNPCSVPWGIKAFSTYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQHLLK
>Mature_278_residues
MELLEEHRCFEGWQQRWRHDSRILNCAMTFSIFLPPPRDNTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPD
TSPRGEQVANNDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPELIQSQFNVSDRCAISGHSMGGHGALIMALKNPG
KYASVSAFAPIVNPCSVPWGIKAFSTYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQHLLK

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=279, Percent_Identity=52.6881720430108, Blast_Score=302, Evalue=3e-82,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=95.6834532374101, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1786551, Length=276, Percent_Identity=53.9855072463768, Blast_Score=323, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17510185, Length=280, Percent_Identity=45, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=44.1077441077441, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=49.1166077738516, Blast_Score=264, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=49.1166077738516, Blast_Score=263, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31303; Mature: 31303

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLEEHRCFEGWQQRWRHDSRILNCAMTFSIFLPPPRDNTPPPVLYWLSGLTCNDENFT
CCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCEEEEECCCEECCCCCC
TKAGAQRVAAELGIVLVMPDTSPRGEQVANNDGYDLGQGAGFYLNATQPPWATHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPELIQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYASVSAFAPIVNPCSVPWG
HHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCC
IKAFSTYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHH
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQHLLK
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELLEEHRCFEGWQQRWRHDSRILNCAMTFSIFLPPPRDNTPPPVLYWLSGLTCNDENFT
CCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCEEEEECCCEECCCCCC
TKAGAQRVAAELGIVLVMPDTSPRGEQVANNDGYDLGQGAGFYLNATQPPWATHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPELIQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYASVSAFAPIVNPCSVPWG
HHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCC
IKAFSTYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHH
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQHLLK
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA