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The map label for this gene is yeiA [H]

Identifier: 218549560

GI number: 218549560

Start: 2288092

End: 2289327

Strand: Direct

Name: yeiA [H]

Synonym: EFER_2232

Alternate gene names: 218549560

Gene position: 2288092-2289327 (Clockwise)

Preceding gene: 218549559

Following gene: 218549567

Centisome position: 49.86

GC content: 50.65

Gene sequence:

>1236_bases
ATGTTAACGAAAGATCTTTCGATTACTTTTTGCGGCGTGAAGTTTCCCAACCCGTTCTGCCTCTCTTCTTCGCCGGTAGG
CAACTGCTATGAGATGTGCGCCAAAGCCTACGACACGGGCTGGGGCGGCGTGGTGTTTAAAACGATCGGCTTTTTTATCG
CCAACGAAGTCTCGCCGCGTTTTGATCATCTGGTGAAAGAAGATACCGGTTTTATCGGCTTCAAAAATATGGAGCAGATT
GCCGAGCATCCGTTGGAAGAGAATCTGGCCGCCCTGCGTCGGCTGAAAGAAGATTATCCTGACAAAGTATTGATCGCCTC
GATCATGGGGGAAAATGAGCAGCAGTGGGAAGATCTGGCGCGCCTGGTGCAAGAAGCTGGTGCCGATATGATCGAGTGTA
ACTTCTCCTGTCCGCAAATGACTTCTCATGCGATGGGTAGCGATGTCGGGCAAAGCCCGGAACTGGTAGAAAAATATTGT
CGGGCGGTGAAACGCGGTTCTACGCTGCCGATGCTGGCGAAGATGACGCCGAATATCGGTGATATGTGCGAAGTGGCGCT
GGCGGCGAAGCGCGGCGGCGCAGATGGCATTGCGGCGATTAACACCGTTAAATCCATTACCAATATCGATCTTAATCAGA
AAATTGGTATGCCGATCGTTAACGGTAAATCGAGTATTTCCGGATATTCCGGTAAAGCGGTAAAACCGATCGCCCTGCGC
TTTATTCAGCAAATGCGCACCCATCCTGAGCTGCGCGATTTCCCGATCAGCGGTATCGGCGGTATTGAAACCTGGGAAGA
TGCGGCAGAGTTTTTATTGCTCGGTGCAGCGACATTACAGGTGACCACCGGTATTATGCAGTACGGGTATCGGATAGTGG
AAGATATGGCGAGCGGGTTATCACATTATCTCGCCGATCAGGGGTTTGATTCGTTGCAGGAGATGGTAGGTCTGGCGAAT
CACAATATTGTCCCGGCGGAAGATTTAGACCGTAGCTATATCGTCTATCCCCATATCAATCTCGATAAATGTGTCGGATG
CGGACGCTGTTATATTTCCTGTTACGACGGCGGTCATCAGGCGATGGAGTGGAATGAGAAAACGCGCACACCGCATTGTA
ATACCGAGAAGTGCGTTGGTTGTCTGCTTTGTGGTCACGTCTGCCCGGTTGGTTGTATTGATCTTGGGGAAGTGAAGTTT
AAGAAAGGTGAGAAAGAACACCCGGTGACGTTGTAG

Upstream 100 bases:

>100_bases
CTGGCGATATTGTTGAGGGTGACAAAACCGTGGTCTATGCAGTGAAAACCGGGAAAGAAGCCGCCGGGGCGATTCATCAC
TATTTAGAGGGAGCTTGCTC

Downstream 100 bases:

>100_bases
AACCAGCGGCGCATCCGGTATTTGGCACCGATTGCCGGATGCGATGCATCCGGCAATACCCAAAATCACATCACTTCTTA
CGTGCGTATTTCAGTGAATC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI
AEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEDLARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN
HNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWNEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKF
KKGEKEHPVTL

Sequences:

>Translated_411_residues
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI
AEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEDLARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN
HNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWNEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKF
KKGEKEHPVTL
>Mature_411_residues
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI
AEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEDLARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN
HNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWNEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKF
KKGEKEHPVTL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=328, Percent_Identity=35.6707317073171, Blast_Score=195, Evalue=8e-50,
Organism=Escherichia coli, GI87082059, Length=411, Percent_Identity=98.7834549878345, Blast_Score=848, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984108, Length=475, Percent_Identity=33.4736842105263, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6322633, Length=240, Percent_Identity=27.9166666666667, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640763, Length=315, Percent_Identity=38.4126984126984, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI18858217, Length=315, Percent_Identity=38.4126984126984, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI281361352, Length=337, Percent_Identity=24.3323442136499, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137316, Length=337, Percent_Identity=24.3323442136499, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45072; Mature: 45072

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEDLA
HHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHH
RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHH
DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHYLADQGFDSLQEMVGLANHNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHCCCCEEEEEEECCCCH
AMEWNEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKFKKGEKEHPVTL
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEDLA
HHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHH
RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHH
DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHYLADQGFDSLQEMVGLANHNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHCCCCEEEEEEECCCCH
AMEWNEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKFKKGEKEHPVTL
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]