Click here to switch to the map view.

The map label for this gene is mglC

Identifier: 218549561

GI number: 218549561

Start: 2289398

End: 2290408

Strand: Reverse

Name: mglC

Synonym: EFER_2233

Alternate gene names: 218549561

Gene position: 2290408-2289398 (Counterclockwise)

Preceding gene: 218549562

Following gene: 218549553

Centisome position: 49.91

GC content: 50.05

Gene sequence:

>1011_bases
ATGAGTGCGTTAAATAAGAAAAGTTTTCTTACTTACCTGAAAGAGGGCGGTATTTACGTCGTTCTTTTAGTTTTGCTGGC
GATTATTATTTTCCAGGACCCAACATTTTTAAGTCTGTTAAACTTAAGCAATATTCTCACCCAGTCATCGGTGCGTATTA
TTATCGCGCTTGGTGTAGCAGGATTAATTGTCACCCAGGGGACTGACCTTTCCGCAGGTCGTCAAGTGGGGCTGGCGGCA
GTAGTCGCGGCGACGTTATTGCAGTCCATGGATAACGCTAACAAAGTATTCCCGGAAATGGCGACGATGCCGATTGCGCT
GGTAATTCTGATTGTCTGTGCCATTGGTGCGGTGATCGGTTTGATCAACGGCCTGATTATCGCTTATCTCAACGTGACGC
CATTCATTACCACGCTCGGCACGATGATTATCGTCTACGGCATCAACTCGCTCTATTACGACTTTGTCGGGGCGTCGCCA
ATTTCTGGTTTTGACAGTGGCTTCTCTACCTTTGCTCAGGGCTTTGTCGCGCTGGGGAGCTTCCGTCTCTCTTACATCAC
TTTCTACGCGTTGATTGCGGTGGCATTCGTCTGGGTGTTGTGGAACAAAACCCGCTTCGGCAAGAACATTTTTGCCATTG
GCGGTAACCCGGAAGCGGCGAAAGTATCTGGTGTCAACGTCGGCCTGAACCTGCTGATGATCTACGCGTTGTCTGGTGTG
TTCTATGCCTTCGGCGGGATGTTAGAAGCCGGACGTATCGGCTCTGCCACCAACAACCTCGGCTTTATGTATGAGCTGGA
TGCTATCGCGGCGTGTGTGGTGGGCGGTGTATCGTTCAGCGGTGGTGTAGGGACGGTGATTGGCGTGGTGACTGGGGTGA
TTATTTTTACCGTCATCAACTATGGCCTGACGTACATCGGCGTAAACCCATACTGGCAGTACATCATCAAAGGGGCGATT
ATTATCTTCGCCGTGGCGCTGGATTCACTGAAATACGCACGTAAGAAGTGA

Upstream 100 bases:

>100_bases
GAGTAATGGCCTCGTTTCCGGAATTGTCGATACAAAAACAACAACGCAAAACGAAATTCTGCGTCTTGCGTCTTTGCACC
TTTAAGATTAGGGGCCTCCC

Downstream 100 bases:

>100_bases
TGTGATTTTGGGTATTGCCGGATGCATCGCATCCGGCAATCGGTGCCAAATACCGGATGCGCCGCTGGTTCTACAACGTC
ACCGGGTGTTCTTTCTCACC

Product: beta-methylgalactoside transporter inner membrane component

Products: ADP; phosphate; beta-D-galactose [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSALNKKSFLTYLKEGGIYVVLLVLLAIIIFQDPTFLSLLNLSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAA
VVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASP
ISGFDSGFSTFAQGFVALGSFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGV
FYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAI
IIFAVALDSLKYARKK

Sequences:

>Translated_336_residues
MSALNKKSFLTYLKEGGIYVVLLVLLAIIIFQDPTFLSLLNLSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAA
VVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASP
ISGFDSGFSTFAQGFVALGSFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGV
FYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAI
IIFAVALDSLKYARKK
>Mature_335_residues
SALNKKSFLTYLKEGGIYVVLLVLLAIIIFQDPTFLSLLNLSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAAV
VAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASPI
SGFDSGFSTFAQGFVALGSFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGVF
YAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAII
IFAVALDSLKYARKK

Specific function: Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane

COG id: COG4211

COG function: function code G; ABC-type glucose/galactose transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. AraH/rbsC subfamily

Homologues:

Organism=Escherichia coli, GI1788471, Length=336, Percent_Identity=100, Blast_Score=650, Evalue=0.0,
Organism=Escherichia coli, GI1790191, Length=323, Percent_Identity=34.6749226006192, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1789992, Length=376, Percent_Identity=30.8510638297872, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790524, Length=332, Percent_Identity=33.433734939759, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788896, Length=332, Percent_Identity=31.9277108433735, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI145693152, Length=321, Percent_Identity=30.2180685358255, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787794, Length=304, Percent_Identity=31.9078947368421, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787793, Length=307, Percent_Identity=29.9674267100977, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082395, Length=304, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693214, Length=269, Percent_Identity=31.5985130111524, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MGLC_ECOLI (P23200)

Other databases:

- EMBL:   M59444
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   C37277
- RefSeq:   AP_002745.1
- RefSeq:   NP_416653.1
- ProteinModelPortal:   P23200
- STRING:   P23200
- EnsemblBacteria:   EBESCT00000004016
- EnsemblBacteria:   EBESCT00000004017
- EnsemblBacteria:   EBESCT00000017362
- GeneID:   949039
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2135
- KEGG:   eco:b2148
- EchoBASE:   EB0589
- EcoGene:   EG10594
- eggNOG:   COG4211
- GeneTree:   EBGT00050000010180
- HOGENOM:   HBG663180
- OMA:   IAIIFVW
- ProtClustDB:   PRK09478
- BioCyc:   EcoCyc:MGLC-MONOMER
- Genevestigator:   P23200
- InterPro:   IPR001851

Pfam domain/function: PF02653 BPD_transp_2

EC number: NA

Molecular weight: Translated: 35551; Mature: 35419

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2a162928)-; HASH(0x29a4f564)-; HASH(0x2a530408)-; HASH(0x2836ea04)-; HASH(0x2a5aabe8)-; HASH(0x2a46f9b8)-; HASH(0x29f61eac)-; HASH(0x29282e18)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALNKKSFLTYLKEGGIYVVLLVLLAIIIFQDPTFLSLLNLSNILTQSSVRIIIALGVA
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEHHH
GLIVTQGTDLSAGRQVGLAAVVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIG
HHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASPISGFDSGFSTFAQGFVALGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGV
HHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEEECCCCCCCEECCCHHHHHHHHHHHHHHH
FYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVIN
HHHHHCHHCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
YGLTYIGVNPYWQYIIKGAIIIFAVALDSLKYARKK
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SALNKKSFLTYLKEGGIYVVLLVLLAIIIFQDPTFLSLLNLSNILTQSSVRIIIALGVA
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEHHH
GLIVTQGTDLSAGRQVGLAAVVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIG
HHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASPISGFDSGFSTFAQGFVALGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGV
HHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEEECCCCCCCEECCCHHHHHHHHHHHHHHH
FYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVIN
HHHHHCHHCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
YGLTYIGVNPYWQYIIKGAIIIFAVALDSLKYARKK
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; beta-D-galactose [Periplasm]; H2O [C]

Specific reaction: ATP + beta-D-galactose [Periplasm] + H2O = ADP + phosphate + beta-D-galactose [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1719366; 9278503