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The map label for this gene is mdtD [H]

Identifier: 218549494

GI number: 218549494

Start: 2204744

End: 2206159

Strand: Direct

Name: mdtD [H]

Synonym: EFER_2164

Alternate gene names: 218549494

Gene position: 2204744-2206159 (Clockwise)

Preceding gene: 218549493

Following gene: 218549495

Centisome position: 48.05

GC content: 55.65

Gene sequence:

>1416_bases
ATGACAGATCTTCCCGACAGCACCCGCTGGCAATTGTGGATTGTGGCTTTCGGCTTCTTTATGCAGTCGCTGGACACCAC
CATCGTTAACACCGCGCTTCCCTCAATGGCTCAAAGCCTCGGGGAAAGCCCGCTGCATATGCACATGGTCATCGTATCTT
ATGTGCTGACCGTGGCGGTGATGCTGCCCGCCAGCGGCTGGCTGGCGGACAAAGTCGGCGTACGCAATATCTTCTTTACC
GCCATCGTGCTGTTTACCCTCGGTTCGCTGTTTTGCGCGCTTTCTGCCACGCTAAACGAACTGTTGCTGGCACGCGCGTT
ACAGGGCGTTGGCGGCGCGATGATGGTGCCGGTCGGCAGGTTGACGGTGATGAAAATTGTACCGCGCGAGCAATATATGG
CGGCGATGACCTTTGTTACGCTGCCCGGGCAAGTCGGTCCGCTGCTTGGTCCGGCGCTCGGCGGCCTGCTGGTGGAATAC
GCGTCCTGGCACTGGATCTTTTTAATCAACATTCCGGTAGGGATTATCGGTGCGATCGCCACGCTGATGTTAATGCCAAA
CTACACCATGCAGACGCGGCGTTTCGATCTCTCCGGTTTTTTATTGCTGGCGGTTGGCATGGCGGTATTAACACTGGCGC
TGGATGGCAGTAAAGGTACTGGTTTATCGCCGCTGGCGATTGCCGGACTGGCAGCGATTGGCGTGGTGGCACTGGTGCTT
TATCTGCTGCACGCCAGAAATAACAACCGCGCCCTGTTCAGCCTGAAACTGTTCCGCACTCGTACCTTTTCGCTGGGCCT
GGCGGGGAGCTTTGCCGGACGTATCGGCAGTGGCATGTTGCCCTTTATGACACCGGTTTTCTTACAGATTGGCCTCGGTT
TCTCGCCGTTTCATGCCGGATTGATGATGATCCCGATGGTGCTCGGCAGCATGGGAATGAAGCGAATTGTAGTGCAGGTG
GTGAATCGCTTTGGTTACCGTCGGGTACTGGTGGCGACCACGCTGGGCCTGTCGCTGGTCACCCTGCTGTTTATGACTAC
CGCTCTGCTGGGCTGGTACTACGTTTTGCCGTTCGTCCTGTTTTTACAAGGGATGGTCAACTCGACGCGTTTCTCCTCTA
TGAACACCCTGACGCTGAAAGATCTACCAGACAATCTGGCGAGCAGCGGCAACAGCCTGCTGTCGATGATTATGCAATTA
TCGATGAGTATCGGCGTCACCATCGCCGGGCTGTTGCTGGGGCTTTTTGGTTCACAGCATGTCAGCGTAGACAGCAGCAC
CACACAAACCGTCTTTATGTACACCTGGCTTAGCATGGCGCTTATCATCGCCCTTCCGGCGTTCATCTTTGCCAGAGTTC
CGAACGATACGCATCAAAATGTCGCTATTTCGCGGCGAAAAAGGAGCGCGCAATGA

Upstream 100 bases:

>100_bases
CCAGCTCCTGACGCTGTATACCACGCCAGTGGTGTATCTCTTCTTCGACCGTCTGCGGCTGCGTTTTTCGCGTAAACCTA
AACAAACGGTAACCGAGTAA

Downstream 100 bases:

>100_bases
AGTTCTGGCGACCCGGTATTACCGGCAAACTGTTTCTGGCGATTTTCGCCACCTGCATTGTCTTATTGATCACGATGCAC
TGGGCGGTACGTATCAGTTT

Product: multidrug efflux system protein MdtE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFT
AIVLFTLGSLFCALSATLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEY
ASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLAAIGVVALVL
YLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQV
VNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL
SMSIGVTIAGLLLGLFGSQHVSVDSSTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ

Sequences:

>Translated_471_residues
MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFT
AIVLFTLGSLFCALSATLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEY
ASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLAAIGVVALVL
YLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQV
VNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL
SMSIGVTIAGLLLGLFGSQHVSVDSSTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ
>Mature_470_residues
TDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTA
IVLFTLGSLFCALSATLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYA
SWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLAAIGVVALVLY
LLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVV
NRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS
MSIGVTIAGLLLGLFGSQHVSVDSSTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1788392, Length=471, Percent_Identity=98.7261146496815, Blast_Score=919, Evalue=0.0,
Organism=Escherichia coli, GI1790195, Length=466, Percent_Identity=45.9227467811159, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1789042, Length=404, Percent_Identity=28.7128712871287, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788710, Length=431, Percent_Identity=28.7703016241299, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081983, Length=429, Percent_Identity=28.9044289044289, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323735, Length=314, Percent_Identity=27.0700636942675, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319770, Length=285, Percent_Identity=28.0701754385965, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322958, Length=174, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=27.3333333333333, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=126, Percent_Identity=30.952380952381, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50920; Mature: 50789

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSATLNELLLARALQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
LTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA
HHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
TLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLAAIGVVALVL
HHHHCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAG
HHHHCCCCCCEEEEEEEHHHHHHEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVL
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQH
HHHHHHCCHHCCCCCEEEEHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVDSSTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSATLNELLLARALQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
LTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA
HHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
TLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLAAIGVVALVL
HHHHCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAG
HHHHCCCCCCEEEEEEEHHHHHHEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVL
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQH
HHHHHHCCHHCCCCCEEEEHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVDSSTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA