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The map label for this gene is tppB [H]

Identifier: 218548770

GI number: 218548770

Start: 1447679

End: 1449184

Strand: Reverse

Name: tppB [H]

Synonym: EFER_1409

Alternate gene names: 218548770

Gene position: 1449184-1447679 (Counterclockwise)

Preceding gene: 218548771

Following gene: 218548769

Centisome position: 31.58

GC content: 49.6

Gene sequence:

>1506_bases
GTGTCAACTGCAAACAATAAACCAACTGAAAGCGTGAGTTTGAACGCTTTCAAACAACCTAAGGCGTTCTATCTCATCTT
CTCGATTGAGCTCTGGGAACGTTTCGGTTACTACGGCCTGCAAGGAATTATGGCTGTTTACCTGGTTAAACAACTGGGTA
TGTCTGAAGCGGATTCGATCACCCTGTTCTCCTCATTTAGTGCTCTCGTTTACGGTCTGGTCGCTATCGGCGGCTGGTTG
GGCGACAAAGTACTGGGTACTAAGCGTGTCATCATGCTTGGTGCAATCGTTCTGGCTATCGGTTATGGGCTTGTTGCATG
GTCCGGGCACGATGTCGGTGTTGTCTATATGGGTATGGCAGCAATCGCTGTGGGTAACGGCTTGTTTAAAGCTAACCCAT
CCTCCCTGCTTTCTACCTGCTATGCGAAAGATGATCCGCGTCTGGACGGTGCATTTACCATGTACTATATGTCCGTCAAC
ATCGGTTCTTTCTTCTCCATGCTGGCAACACCATGGCTGGCTGACCGGTATGGCTGGAGCGTAGCATTCGCACTGAGCGT
AGTGGGCCTGATTATTACCATCGTTAACTTCGCTTTCTGCCAACGTTGGGTTAAACAGTACGGTTCCAAACCTGACTTCG
CGCCAGTTAACTACCGTAACCTGTTGCTGACCATCATCGGTGTTATTGCACTGATCGCGATCGCTACCTGGCTGCTGCAC
AACCAGGAAATTGCACGCATGGCACTGGGCGTTGTTGCTCTGGGTATCGTCTTTATCTTTGGTAAAGAAGCTATCGCCAT
GAAAGGTGCTGCACGTCGTAAAATGATCGTTGCATTCATCCTGATGCTAGAAGCCATTATCTTCTTCGTGCTTTATAGCC
AGATGCCAACGTCACTGAACTTCTTTGCGATTCGTAACGTTGAACACACCATTCTGGGCATGACGGTTGTACCTGAACAG
TACCAGGCACTTAACCCGTTCTGGATCATCATTGGTAGCCCTATTCTGGCCGCTCTGTATAACAAGATGGGCGATACTCT
GCCGATGCCAACTAAGTTCGCTATCGGTATGGTGATGTGCTCCGGTGCGTTCCTGATCCTGCCACTGGGTGCAAAATTCG
CCACTGACGCGGGTATCGTTTCCTCTGGCTGGCTGGTGGCAAGCTACGGCCTGCAGAGTATCGGTGAACTGATGATTTCT
GGTCTGGGTCTGGCAATGGTTGCTCAGCTCGTTCCACAGCGTCTGATGGGCTTTATTATGGGTAGCTGGTTCCTGACCAC
TGCCGGTGCCAACATCATTGGCGGTTATGTTGCCAACATGATGGCTGTACCAGAAAATGTTTCCGATCCACTGATGTCTC
TGGAAGTCTATGGTCGCGTATTTATGCAGATCGGTATCGTTACTGCGGTAATTGCTGTCCTGATGCTGCTGACTGCTCCG
AAACTGAATCGTATGACTCAGGACGATTCAGATGACAAAAAAGCATCTAAAACTGCGACTGCGTAA

Upstream 100 bases:

>100_bases
CCTGCCGTTTCCCCTCCCACTATAACAATGCACGAATGTACTGACGGCATAACGTGCCAGAACACCCCCGTTAATATGGG
ATGTAAAAAAAGAGGTTAAA

Downstream 100 bases:

>100_bases
GTTTTAAGGGAAACGCTTTTTTAAGCCGCTAACTTTGCGTTAGCGGCTTTTTTTTTACCCATTTGCGCACTACCATGATC
TTTCAATCAGTCAAAAGGAG

Product: tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSTANNKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKVLGTKRVIMLGAIVLAIGYGLVAWSGHDVGVVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVN
IGSFFSMLATPWLADRYGWSVAFALSVVGLIITIVNFAFCQRWVKQYGSKPDFAPVNYRNLLLTIIGVIALIAIATWLLH
NQEIARMALGVVALGIVFIFGKEAIAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHTILGMTVVPEQ
YQALNPFWIIIGSPILAALYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFATDAGIVSSGWLVASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANMMAVPENVSDPLMSLEVYGRVFMQIGIVTAVIAVLMLLTAP
KLNRMTQDDSDDKKASKTATA

Sequences:

>Translated_501_residues
MSTANNKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKVLGTKRVIMLGAIVLAIGYGLVAWSGHDVGVVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVN
IGSFFSMLATPWLADRYGWSVAFALSVVGLIITIVNFAFCQRWVKQYGSKPDFAPVNYRNLLLTIIGVIALIAIATWLLH
NQEIARMALGVVALGIVFIFGKEAIAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHTILGMTVVPEQ
YQALNPFWIIIGSPILAALYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFATDAGIVSSGWLVASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANMMAVPENVSDPLMSLEVYGRVFMQIGIVTAVIAVLMLLTAP
KLNRMTQDDSDDKKASKTATA
>Mature_500_residues
STANNKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLG
DKVLGTKRVIMLGAIVLAIGYGLVAWSGHDVGVVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVNI
GSFFSMLATPWLADRYGWSVAFALSVVGLIITIVNFAFCQRWVKQYGSKPDFAPVNYRNLLLTIIGVIALIAIATWLLHN
QEIARMALGVVALGIVFIFGKEAIAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHTILGMTVVPEQY
QALNPFWIIIGSPILAALYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFATDAGIVSSGWLVASYGLQSIGELMISG
LGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANMMAVPENVSDPLMSLEVYGRVFMQIGIVTAVIAVLMLLTAPK
LNRMTQDDSDDKKASKTATA

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=387, Percent_Identity=23.7726098191214, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI226371746, Length=354, Percent_Identity=25.1412429378531, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787922, Length=487, Percent_Identity=93.2238193018481, Blast_Score=926, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=481, Percent_Identity=51.5592515592516, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1790572, Length=491, Percent_Identity=29.1242362525458, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786927, Length=477, Percent_Identity=28.9308176100629, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17541704, Length=378, Percent_Identity=24.0740740740741, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71987453, Length=376, Percent_Identity=22.8723404255319, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17569141, Length=341, Percent_Identity=24.0469208211144, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639585, Length=344, Percent_Identity=26.1627906976744, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24639581, Length=329, Percent_Identity=26.1398176291793, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639583, Length=329, Percent_Identity=26.1398176291793, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28571098, Length=368, Percent_Identity=24.4565217391304, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571102, Length=368, Percent_Identity=24.4565217391304, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571100, Length=368, Percent_Identity=24.4565217391304, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 54263; Mature: 54132

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50850 MFS ; PS01022 PTR2_1 ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTANNKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
TLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYGLVAWSGHDVGVVYMGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHH
AIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVNIGSFFSMLATPWLADRYGWS
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEECHHHHHHHHHCCHHHHHCCHH
VAFALSVVGLIITIVNFAFCQRWVKQYGSKPDFAPVNYRNLLLTIIGVIALIAIATWLLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NQEIARMALGVVALGIVFIFGKEAIAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLN
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FFAIRNVEHTILGMTVVPEQYQALNPFWIIIGSPILAALYNKMGDTLPMPTKFAIGMVMC
EEEECCCCHHHEEEEECCHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHH
SGAFLILPLGAKFATDAGIVSSGWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM
CCCEEEEECCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GSWFLTTAGANIIGGYVANMMAVPENVSDPLMSLEVYGRVFMQIGIVTAVIAVLMLLTAP
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLNRMTQDDSDDKKASKTATA
HHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
STANNKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC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HHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]