| Definition | Escherichia fergusonii ATCC 35469 chromosome, complete genome. |
|---|---|
| Accession | NC_011740 |
| Length | 4,588,711 |
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The map label for this gene is sppA [H]
Identifier: 218548665
GI number: 218548665
Start: 1337250
End: 1339385
Strand: Reverse
Name: sppA [H]
Synonym: EFER_1299
Alternate gene names: 218548665
Gene position: 1339385-1337250 (Counterclockwise)
Preceding gene: 218548670
Following gene: 218548664
Centisome position: 29.19
GC content: 48.83
Gene sequence:
>2136_bases TTGTGGTCCGGTGCACGCATTCCGGCACGCAAAATATTTTGCAGTTGTTCACCCGCAGGTGCAGGTTCTGCCAGGCGAGA AGCGCTACGGCGGTTAATCAGCAGATCAAGTGCATCCATTTTGTTAACTCCTGTCATGGTGTTTATTCACAAAATTAACA CGGACGCAGAATTTGTTACAGCGCAGACAGTGATTCCTGCTGACAAGAGGCAACCTGATCATTACGATAGCCACATCTTA TGCGTCTGTACCAGACGTAATTTTACGAAGGGAGAATACATGCGAACCCTATGGCGATTTGTAGCCGGATTTTTTAAATG GACATGGCGACTGCTCAACTTTGTCCGTGAAATGGTCCTTAATTTGTTATTTATTTTCCTGGTGCTGATCGGTGTCGGTA TCTGGATGCAAGTCAGCAGTAATGGCAGTAGCGACTCCGCCAGTCGGGGCGCATTGCTGCTGGATATCTCCGGTGTAATT GTGGATAAACCCTCCAACAATCACCGACTGGGGGTGATTGGTCGCCAGTTATTTGGCGCCAGCTCTGAACGTCTGCAAGA AAACTCATTGTTTGACATCGTTAATACGATTCGTCAGGCGAAAGATGACAGCAATATCACCGGAATTGTGTTGGATCTGG AAAACTTTGCGGGTGCAGATCAACCGTCGATGCAATATATCGGCAAAGCACTACGTGAGTTCCGTGACAGTGGTAAACCC GTGATTGCTATTGGTGAAAGCTATACCCAGGGGCAGTATTATCTGGCCAGTTTCGCCAACAAAATCTGGCTTTCCCCTCA GGGCACGGTTGATCTACATGGTTTTGCAACTAATGGCCTGTACTACAAATCCCTGCTCGATAAGCTGAAAGTCTCCACTC ATGTATTCCGCGTTGGGACTTATAAATCAGCTGTTGAACCATTTATTCGCGATGATATGTCTCCGGCAGCCCGTGAAGCT GACAGCCGCTGGGTTGGCGAACTGTGGCAGAACTATCTCAACACTATTGCCGCCAATCGGCAAATTTCTGCCCAACAAGT CTTCCCCGGTGCCCAGGCGATGATTGCTGATCTGACTAAACTGGGCGGCGATACTGCACAATACGCACTCGACCATAAAC TGGTTGATGCGCTGGGCTCCAGTGCTGATGTCGAAAAAGCACTGACCAAGCAATTTGGCTGGAGCAAAGCCGATAAAAAT TATCGTGCGATCAGTTTCTATGACTATGCGTTGAAAACTCCAGTGAAAACACCAGAGATGATTGGTGTGGTCTTTGCCAA CGGCGCGATTATGGACGGTGAAGAAACACCGGGTAATGTCGGTGGTGACACTACAGCAGCGCAAATCCGCGATGCACGTC TTGATCCAAAAGTGAAAGCGATTGTATTGCGTGTTAATAGCCCAGGCGGAAGTGTCACGGCTTCAGAGGTCATTCGTTCC GAACTGGCTGCAGCGAAAGCAGCGGGTAAACCGGTGGTAGTGTCGATGGGTGGAATGGCCGCTTCCGGTGGTTATTGGAT CTCCACGCCGGCTAATTACATCATCGCCAACCCCAGCACGCTGACGGGTTCTATCGGTATTTTTGGGGTAATTAATACCG TTGAAAATAGCCTTGATTCCATTGGCGTTCACACCGATGGTGTATCCACTTCTCCACTGGCGAATATGTCTGTTACACAG TCATTACCCACAGAAGTGCAGCAGATGATGCAGTTAAGCATTGAAAATGGCTATAAACGCTTTATCACTCTGGTCGCCGA TGCGCGTAAATCAACACCAGAACAGGTAGACAAAATTGCGCAGGGTCACGTATGGACTGGCGAAGATGCCAAAGCAAATG GTCTGGTCGATAGTCTCGGTGATTTCGATGATGCGGTTGCTAAAGCGGCTGAGCTGGCGAAGTTGAAACAGTGGAGTATC AATTACTATCAGGATGAACCGACGTTCTTCGATATGGTTGTCGATAGCATGTCTGGTTCCGTTCGCGCAATGTTACCGCA GGCTATTCAGGCGATGCTTCCGGCACCGCTGGCAACAGCGGCAAGTGCGGTAAAAGCTGAAAGCGATAAACTGGCAGCAT TTAATGATCCACAAAATCGTTATGCATTCTGCCTGACCTGTGCCAACGTGCGTTAA
Upstream 100 bases:
>100_bases TTCATCGCTATCGGCTGCCAGCGCACCTTGTTCCAGAACAGCACTAAAACGTTCACGTCCTTCGCCCTCAATAACAAAGA AATGCCACGGTTGCAGGGAC
Downstream 100 bases:
>100_bases ATCAGCAAATTATGTGGCCAATGAAATTCTTCTGCGGCCACATTTTTTTGTCTCCAGAATCAGACTGTTTTTCACGGCAT AACAAGACTAGAGTGCCTTC
Product: protease 4
Products: NA
Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]
Number of amino acids: Translated: 711; Mature: 711
Protein sequence:
>711_residues MWSGARIPARKIFCSCSPAGAGSARREALRRLISRSSASILLTPVMVFIHKINTDAEFVTAQTVIPADKRQPDHYDSHIL CVCTRRNFTKGEYMRTLWRFVAGFFKWTWRLLNFVREMVLNLLFIFLVLIGVGIWMQVSSNGSSDSASRGALLLDISGVI VDKPSNNHRLGVIGRQLFGASSERLQENSLFDIVNTIRQAKDDSNITGIVLDLENFAGADQPSMQYIGKALREFRDSGKP VIAIGESYTQGQYYLASFANKIWLSPQGTVDLHGFATNGLYYKSLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREA DSRWVGELWQNYLNTIAANRQISAQQVFPGAQAMIADLTKLGGDTAQYALDHKLVDALGSSADVEKALTKQFGWSKADKN YRAISFYDYALKTPVKTPEMIGVVFANGAIMDGEETPGNVGGDTTAAQIRDARLDPKVKAIVLRVNSPGGSVTASEVIRS ELAAAKAAGKPVVVSMGGMAASGGYWISTPANYIIANPSTLTGSIGIFGVINTVENSLDSIGVHTDGVSTSPLANMSVTQ SLPTEVQQMMQLSIENGYKRFITLVADARKSTPEQVDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWSI NYYQDEPTFFDMVVDSMSGSVRAMLPQAIQAMLPAPLATAASAVKAESDKLAAFNDPQNRYAFCLTCANVR
Sequences:
>Translated_711_residues MWSGARIPARKIFCSCSPAGAGSARREALRRLISRSSASILLTPVMVFIHKINTDAEFVTAQTVIPADKRQPDHYDSHIL CVCTRRNFTKGEYMRTLWRFVAGFFKWTWRLLNFVREMVLNLLFIFLVLIGVGIWMQVSSNGSSDSASRGALLLDISGVI VDKPSNNHRLGVIGRQLFGASSERLQENSLFDIVNTIRQAKDDSNITGIVLDLENFAGADQPSMQYIGKALREFRDSGKP VIAIGESYTQGQYYLASFANKIWLSPQGTVDLHGFATNGLYYKSLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREA DSRWVGELWQNYLNTIAANRQISAQQVFPGAQAMIADLTKLGGDTAQYALDHKLVDALGSSADVEKALTKQFGWSKADKN YRAISFYDYALKTPVKTPEMIGVVFANGAIMDGEETPGNVGGDTTAAQIRDARLDPKVKAIVLRVNSPGGSVTASEVIRS ELAAAKAAGKPVVVSMGGMAASGGYWISTPANYIIANPSTLTGSIGIFGVINTVENSLDSIGVHTDGVSTSPLANMSVTQ SLPTEVQQMMQLSIENGYKRFITLVADARKSTPEQVDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWSI NYYQDEPTFFDMVVDSMSGSVRAMLPQAIQAMLPAPLATAASAVKAESDKLAAFNDPQNRYAFCLTCANVR >Mature_711_residues MWSGARIPARKIFCSCSPAGAGSARREALRRLISRSSASILLTPVMVFIHKINTDAEFVTAQTVIPADKRQPDHYDSHIL CVCTRRNFTKGEYMRTLWRFVAGFFKWTWRLLNFVREMVLNLLFIFLVLIGVGIWMQVSSNGSSDSASRGALLLDISGVI VDKPSNNHRLGVIGRQLFGASSERLQENSLFDIVNTIRQAKDDSNITGIVLDLENFAGADQPSMQYIGKALREFRDSGKP VIAIGESYTQGQYYLASFANKIWLSPQGTVDLHGFATNGLYYKSLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREA DSRWVGELWQNYLNTIAANRQISAQQVFPGAQAMIADLTKLGGDTAQYALDHKLVDALGSSADVEKALTKQFGWSKADKN YRAISFYDYALKTPVKTPEMIGVVFANGAIMDGEETPGNVGGDTTAAQIRDARLDPKVKAIVLRVNSPGGSVTASEVIRS ELAAAKAAGKPVVVSMGGMAASGGYWISTPANYIIANPSTLTGSIGIFGVINTVENSLDSIGVHTDGVSTSPLANMSVTQ SLPTEVQQMMQLSIENGYKRFITLVADARKSTPEQVDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWSI NYYQDEPTFFDMVVDSMSGSVRAMLPQAIQAMLPAPLATAASAVKAESDKLAAFNDPQNRYAFCLTCANVR
Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]
COG id: COG0616
COG function: function code OU; Periplasmic serine proteases (ClpP class)
Gene ontology:
Cell location: Cell inner membrane; Single-pass membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase S49 family [H]
Homologues:
Organism=Escherichia coli, GI1788064, Length=618, Percent_Identity=86.2459546925566, Blast_Score=1103, Evalue=0.0, Organism=Escherichia coli, GI1787527, Length=175, Percent_Identity=27.4285714285714, Blast_Score=69, Evalue=8e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004634 - InterPro: IPR004635 - InterPro: IPR002142 [H]
Pfam domain/function: PF01343 Peptidase_S49 [H]
EC number: 3.4.21.-
Molecular weight: Translated: 77306; Mature: 77306
Theoretical pI: Translated: 8.10; Mature: 8.10
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MWSGARIPARKIFCSCSPAGAGSARREALRRLISRSSASILLTPVMVFIHKINTDAEFVT CCCCCCCCHHHEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEE AQTVIPADKRQPDHYDSHILCVCTRRNFTKGEYMRTLWRFVAGFFKWTWRLLNFVREMVL EEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NLLFIFLVLIGVGIWMQVSSNGSSDSASRGALLLDISGVIVDKPSNNHRLGVIGRQLFGA HHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECEEEEECCCCCCEEEEEHHHHHCC SSERLQENSLFDIVNTIRQAKDDSNITGIVLDLENFAGADQPSMQYIGKALREFRDSGKP CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCC VIAIGESYTQGQYYLASFANKIWLSPQGTVDLHGFATNGLYYKSLLDKLKVSTHVFRVGT EEEECCCCCCCHHHHHHHHHHEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHEEEECC YKSAVEPFIRDDMSPAAREADSRWVGELWQNYLNTIAANRQISAQQVFPGAQAMIADLTK HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHH LGGDTAQYALDHKLVDALGSSADVEKALTKQFGWSKADKNYRAISFYDYALKTPVKTPEM HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHCCCCCCCHH IGVVFANGAIMDGEETPGNVGGDTTAAQIRDARLDPKVKAIVLRVNSPGGSVTASEVIRS EEEEEECCEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHH ELAAAKAAGKPVVVSMGGMAASGGYWISTPANYIIANPSTLTGSIGIFGVINTVENSLDS HHHHHHHCCCCEEEEECCEEECCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH IGVHTDGVSTSPLANMSVTQSLPTEVQQMMQLSIENGYKRFITLVADARKSTPEQVDKIA CCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH QGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWSINYYQDEPTFFDMVVDSMSGS CCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCC VRAMLPQAIQAMLPAPLATAASAVKAESDKLAAFNDPQNRYAFCLTCANVR HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCCCCCEEEEEEECCCC >Mature Secondary Structure MWSGARIPARKIFCSCSPAGAGSARREALRRLISRSSASILLTPVMVFIHKINTDAEFVT CCCCCCCCHHHEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEE AQTVIPADKRQPDHYDSHILCVCTRRNFTKGEYMRTLWRFVAGFFKWTWRLLNFVREMVL EEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NLLFIFLVLIGVGIWMQVSSNGSSDSASRGALLLDISGVIVDKPSNNHRLGVIGRQLFGA HHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECEEEEECCCCCCEEEEEHHHHHCC SSERLQENSLFDIVNTIRQAKDDSNITGIVLDLENFAGADQPSMQYIGKALREFRDSGKP CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCC VIAIGESYTQGQYYLASFANKIWLSPQGTVDLHGFATNGLYYKSLLDKLKVSTHVFRVGT EEEECCCCCCCHHHHHHHHHHEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHEEEECC YKSAVEPFIRDDMSPAAREADSRWVGELWQNYLNTIAANRQISAQQVFPGAQAMIADLTK HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHH LGGDTAQYALDHKLVDALGSSADVEKALTKQFGWSKADKNYRAISFYDYALKTPVKTPEM HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHCCCCCCCHH IGVVFANGAIMDGEETPGNVGGDTTAAQIRDARLDPKVKAIVLRVNSPGGSVTASEVIRS EEEEEECCEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHH ELAAAKAAGKPVVVSMGGMAASGGYWISTPANYIIANPSTLTGSIGIFGVINTVENSLDS HHHHHHHCCCCEEEEECCEEECCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH IGVHTDGVSTSPLANMSVTQSLPTEVQQMMQLSIENGYKRFITLVADARKSTPEQVDKIA CCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH QGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWSINYYQDEPTFFDMVVDSMSGS CCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCC VRAMLPQAIQAMLPAPLATAASAVKAESDKLAAFNDPQNRYAFCLTCANVR HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCCCCCEEEEEEECCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11677608; 12644504 [H]