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The map label for this gene is lpxK

Identifier: 218548431

GI number: 218548431

Start: 1095869

End: 1096855

Strand: Direct

Name: lpxK

Synonym: EFER_1059

Alternate gene names: 218548431

Gene position: 1095869-1096855 (Clockwise)

Preceding gene: 218548430

Following gene: 218548432

Centisome position: 23.88

GC content: 51.17

Gene sequence:

>987_bases
ATGATTGAGCGCATCTGGTCCGGTGAATCGCCCTTGTGGCGGTTGTTATTACCACTCTCCTGGTTGTATGGCCTGGTGAG
TGGTCTGATTCGCCTGTGCTATAAATTAGGATTAAAGCGTGCCTGGCGCGCGCCTGTTCCTGTGGTGGTGGTGGGGAATC
TTACCGCGGGTGGTAATGGTAAAACGCCAGTTGTTATTTGGCTGGTAGAGCAACTGCAACAACGTGGCGTTCGGGTCGGT
GTGGTGTCTCGCGGTTACGGTGGTAAAGCTGAGTCATATCCACTTTTGCTTAGTGACGATACTACTACCGCACAAGCTGG
CGATGAGCCAGTACTGATTTATCAGCGTACAGGTGCTCCTGTTGCCGTTTCACCTGTTCGCAGCGATGCAGTAAAAGCGA
TTCTGACACAACATCCTGATATGCAGATTATCGTAACCGACGATGGGCTTCAGCATTATCGACTGGCGCGTGATGTTGAA
GTTGTGGTGATTGATGGTGTACGTCGCTTCGGTAATGGCTGGTGGTTACCAGCCGGACCAATGCGAGAGCGTGCCGGGCG
GTTAAAAACTGTAGATACTGTGATCGTTAACGGTGGTGTACCACGCAGCGGTGAAATCCCAATGCATCTTGCTCCAGGGC
AGGCTGTTAATTTACGTACTGGCACCCGCTGCGATATAGCCAAACTTACGCATGTCGTTGCAATGGCTGGAATAGGGCAC
CCGCCGCGCTTTTTCGCCACGCTGAAAATGTGCGGCGTTAACCCGGAAAAATGTGTACCGTTGGCCGATCACCAGTCACT
TACGCACTCAGATGTTTGCGCATTGTTGAACAGTGGGCAAACATTGGTCATGACCGAAAAAGATGCCGTAAAATGTCGTG
CATTTGCGGAAGATAATTGGTGGTATCTCCCAGTAGATGCCCGATTTGCGGGGCATGAACCAGAGCAACTTCTTGCAAAA
CTTATTTCGCTGGCTTCAGGTGAATAG

Upstream 100 bases:

>100_bases
TTGTGGTAGAAGATGGTGTAATTGTTGAACGCGGTACGCATAGTGATTTGCTGGCGCATCGTGGTGTCTATGCGCAACTG
CATAAAATGCAATTTGGCCA

Downstream 100 bases:

>100_bases
TAACGCTGTGGCGGCACTTGATTGACGAGGTCATAAATGTCGCTGCAGCACCTTACCCTTACAGATGCCCGTAATCTCCA
TCTTGCTGCGCAGGGGATGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MIERIWSGESPLWRLLLPLSWLYGLVSGLIRLCYKLGLKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGVRVG
VVSRGYGGKAESYPLLLSDDTTTAQAGDEPVLIYQRTGAPVAVSPVRSDAVKAILTQHPDMQIIVTDDGLQHYRLARDVE
VVVIDGVRRFGNGWWLPAGPMRERAGRLKTVDTVIVNGGVPRSGEIPMHLAPGQAVNLRTGTRCDIAKLTHVVAMAGIGH
PPRFFATLKMCGVNPEKCVPLADHQSLTHSDVCALLNSGQTLVMTEKDAVKCRAFAEDNWWYLPVDARFAGHEPEQLLAK
LISLASGE

Sequences:

>Translated_328_residues
MIERIWSGESPLWRLLLPLSWLYGLVSGLIRLCYKLGLKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGVRVG
VVSRGYGGKAESYPLLLSDDTTTAQAGDEPVLIYQRTGAPVAVSPVRSDAVKAILTQHPDMQIIVTDDGLQHYRLARDVE
VVVIDGVRRFGNGWWLPAGPMRERAGRLKTVDTVIVNGGVPRSGEIPMHLAPGQAVNLRTGTRCDIAKLTHVVAMAGIGH
PPRFFATLKMCGVNPEKCVPLADHQSLTHSDVCALLNSGQTLVMTEKDAVKCRAFAEDNWWYLPVDARFAGHEPEQLLAK
LISLASGE
>Mature_328_residues
MIERIWSGESPLWRLLLPLSWLYGLVSGLIRLCYKLGLKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGVRVG
VVSRGYGGKAESYPLLLSDDTTTAQAGDEPVLIYQRTGAPVAVSPVRSDAVKAILTQHPDMQIIVTDDGLQHYRLARDVE
VVVIDGVRRFGNGWWLPAGPMRERAGRLKTVDTVIVNGGVPRSGEIPMHLAPGQAVNLRTGTRCDIAKLTHVVAMAGIGH
PPRFFATLKMCGVNPEKCVPLADHQSLTHSDVCALLNSGQTLVMTEKDAVKCRAFAEDNWWYLPVDARFAGHEPEQLLAK
LISLASGE

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=328, Percent_Identity=89.3292682926829, Blast_Score=606, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_ESCF3 (B7LN77)

Other databases:

- EMBL:   CU928158
- RefSeq:   YP_002382222.1
- EnsemblBacteria:   EBESCT00000123656
- GeneID:   7120970
- GenomeReviews:   CU928158_GR
- KEGG:   efe:EFER_1059
- GeneTree:   EBGT00050000009959
- HOGENOM:   HBG663914
- ProtClustDB:   PRK00652
- BioCyc:   EFER585054:EFER_1059-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35756; Mature: 35756

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERIWSGESPLWRLLLPLSWLYGLVSGLIRLCYKLGLKRAWRAPVPVVVVGNLTAGGNG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGVRVGVVSRGYGGKAESYPLLLSDDTTTAQAGDEPVLIYQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPVRSDAVKAILTQHPDMQIIVTDDGLQHYRLARDVEVVVIDGVRRFGNGWWLPAGP
EEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEECHHHHCCCCCCCCCH
MRERAGRLKTVDTVIVNGGVPRSGEIPMHLAPGQAVNLRTGTRCDIAKLTHVVAMAGIGH
HHHHCCCCEEEEEEEEECCCCCCCCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHCCCC
PPRFFATLKMCGVNPEKCVPLADHQSLTHSDVCALLNSGQTLVMTEKDAVKCRAFAEDNW
CHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEEEEEECCCC
WYLPVDARFAGHEPEQLLAKLISLASGE
EEEEECCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIERIWSGESPLWRLLLPLSWLYGLVSGLIRLCYKLGLKRAWRAPVPVVVVGNLTAGGNG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGVRVGVVSRGYGGKAESYPLLLSDDTTTAQAGDEPVLIYQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPVRSDAVKAILTQHPDMQIIVTDDGLQHYRLARDVEVVVIDGVRRFGNGWWLPAGP
EEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEECHHHHCCCCCCCCCH
MRERAGRLKTVDTVIVNGGVPRSGEIPMHLAPGQAVNLRTGTRCDIAKLTHVVAMAGIGH
HHHHCCCCEEEEEEEEECCCCCCCCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHCCCC
PPRFFATLKMCGVNPEKCVPLADHQSLTHSDVCALLNSGQTLVMTEKDAVKCRAFAEDNW
CHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEEEEEECCCC
WYLPVDARFAGHEPEQLLAKLISLASGE
EEEEECCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA