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The map label for this gene is sdaC [H]

Identifier: 218547685

GI number: 218547685

Start: 278861

End: 280150

Strand: Reverse

Name: sdaC [H]

Synonym: EFER_0264

Alternate gene names: 218547685

Gene position: 280150-278861 (Counterclockwise)

Preceding gene: 218547686

Following gene: 218547684

Centisome position: 6.11

GC content: 52.25

Gene sequence:

>1290_bases
ATGGAAACGACTCAAACCAGCACGATTGTGTCGAAAGACTCACGTAGTGCATGGCGCAAAACTGACACCATGTGGATGCT
GGGCCTGTACGGCACAGCGATCGGTGCTGGTGTACTATTCCTGCCAATCAACGCCGGTGTTGGCGGTATGATCCCGCTGA
TCATCATGGCTATTCTCGCGTTCCCGATGACGTTTTTCGCGCACCGTGGCCTGACCCGCTTCGTGCTGTCTGGTAAAAAC
CCAGGCGAAGACATCACCGAGGTGGTAGAAGAACACTTTGGTATTGGCGCTGGTAAACTAATTACTCTGCTGTACTTCTT
TGCTATCTACCCGATCCTGCTGGTTTACAGTGTGGCAATCACCAACACTGTCGAAAGCTTCATGACCCACCAGCTGAGCA
TGACGCCGCCGCCGCGTGCGATTCTGTCGCTGATCCTGATCGTGGGTATGATGACCATCGTTCGCTTCGGTGAGCAGATG
ATCGTTAAGGCGATGAGTATTCTGGTATTCCCGTTTGTTGGCGTCCTGATGCTGCTGGCTCTGTACCTGATCCCGCAGTG
GAACGGCGCAGCACTGGAAACTCTGTCTCTGGACACTGCATCTGCAACCGGAAACGGTCTGTGGATGACCCTGTGGCTGG
CGATTCCGGTAATGGTGTTCTCGTTCAACCACTCTCCGATCATCTCTTCTTTCGCCGTTGCGAAGCGTGAAGAGTACGGC
GATATGGCAGAAAAGAAATGCTCGAAGATCCTGGCATTCGCACACATCATGATGGTGCTGACTGTAATGTTCTTCGTTTT
CAGCTGCGTACTGAGCCTGTCTCCGGCAGACCTGGCTGCGGCTAAAGAGCAGAACATCTCGATTCTGTCTTACCTGGCTA
ACCACTTTAACGCACCGATCATCGCGTGGATGGCTCCGATTATCGCGATTATCGCTATCACCAAATCCTTCCTCGGCCAC
TACCTGGGCGCACGTGAAGGCTTCAACGGTATGGTGATTAAATCTCTGCGTGGTAAAGGTAAGTCTATCGAAATCAACAA
GCTGAACCGTATCACTGCGCTGTTCATGCTGGTAACGACCTGGATTGTTGCCACCCTGAACCCGAGCATCCTGGGTATGA
TTGAAACCCTGGGCGGCCCAATCATCGCGATGATCCTGTTCCTGATGCCGATGTACGCAATCCAGAAAGTACCGGCAATG
CGTAAGTACAGCGGTCACATCAGCAACGTATTCGTTGTCGTGATGGGTCTGATTGCAATCTCCGCAATCTTCTACTCTCT
GTTCAGCTAA

Upstream 100 bases:

>100_bases
TACTCCCGTCGTCCACAGACAGATTTCATTTTACGGTTATGCCCCTTTCACGGTCGGCCTGACCAAAAACCTGATTTTTT
GCATTCTCCAGGAGAAATTG

Downstream 100 bases:

>100_bases
GTTCTTTCGCGCCGCTTTCGGGCGGCGCTTCCTCCGTTTTAACGCGATGTATTTCCTATGATTAGCGTATTCGATATTTT
CAAAATCGGCATTGGCCCTT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
METTQTSTIVSKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFMTHQLSMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVGVLMLLALYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
DMAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAIIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVVMGLIAISAIFYSLFS

Sequences:

>Translated_429_residues
METTQTSTIVSKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFMTHQLSMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVGVLMLLALYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
DMAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAIIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVVMGLIAISAIFYSLFS
>Mature_429_residues
METTQTSTIVSKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFMTHQLSMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVGVLMLLALYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
DMAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAIIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVVMGLIAISAIFYSLFS

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=98.6013986013986, Blast_Score=853, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=442, Percent_Identity=50.9049773755656, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1789211, Length=415, Percent_Identity=38.7951807228916, Blast_Score=297, Evalue=7e-82,
Organism=Escherichia coli, GI145693183, Length=422, Percent_Identity=28.6729857819905, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1789961, Length=410, Percent_Identity=25.8536585365854, Blast_Score=124, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46979; Mature: 46979

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTQTSTIVSKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFMTHQLSMTPPPRAILSLILIVGMMTIVRFGEQMIVKAMSILVFPFVGVLMLLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHCCCCCCCEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DMAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCH
IAWMAPIIAIIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVVMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHC
>Mature Secondary Structure
METTQTSTIVSKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFMTHQLSMTPPPRAILSLILIVGMMTIVRFGEQMIVKAMSILVFPFVGVLMLLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHCCCCCCCEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DMAEKKCSKILAFAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCH
IAWMAPIIAIIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVVMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]