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The map label for this gene is degP [H]

Identifier: 218547617

GI number: 218547617

Start: 202608

End: 204032

Strand: Direct

Name: degP [H]

Synonym: EFER_0184

Alternate gene names: 218547617

Gene position: 202608-204032 (Clockwise)

Preceding gene: 218547616

Following gene: 218547618

Centisome position: 4.42

GC content: 50.88

Gene sequence:

>1425_bases
ATGAAAAAAACCACATTAGCACTGAGTGCATTGGCTCTGAGTTTAGGTTTGGCGCTTTCTCCTCTTTCTGCAACGGCGGC
TGAAGCCACTCCGGCAGCGTCAGCTCAGCAGATGCCAAGCCTGGCTCCGATGCTCGAAAAGGTGATGCCATCGGTGGTCA
GTATTAACGTAGAAGGTAGCACAACCGTAAATACGCCGCGTATGCCGCGTAATTTCCAGCAGTTCTTTGGGGATGATTCC
CCGTTCTGTCAGGAAGGTTCTCCGTTCCAGAGTTCTCCATTCTGCCAGGGTGGTCCTGGTGGAAATGGCGGCGGCCAGAC
ACAAAAATTTATGTCCCTGGGCTCAGGTGTCATTATTGACGCTGAGAAAGGCTACGTAGTTACCAACAACCACGTTGTTG
ATAACGCCAATGTGATTAAAGTGCAACTGAGCGATGGTCGTAAGTTCGACGCGAAGATGGTCGGCAAAGATCCTCGTTCT
GACATCGCGCTGATTCAGATTCAAAATCCGAAAAACCTGACTGCTATTAAGATGGCGGATTCTGACGCCTTGCGTGTGGG
TGACTACACCGTTGCTATCGGTAACCCATTCGGTCTGGGGGAAACGGTAACTTCAGGTATCGTTTCTGCTCTGGGGCGTA
GCGGTCTGAACGTAGAAAACTACGAAAACTTTATTCAGACGGATGCCGCAATCAACCGTGGTAACTCCGGTGGTGCGCTG
GTTAACCTGAATGGTGAACTGATCGGGATTAATACCGCGATCCTCGCACCAGATGGCGGTAACATCGGTATCGGTTTTGC
AATCCCAAGCAATATGGTGAAAAACCTGACATCTCAGATGGTTGAATTCGGTCAGGTGAAACGCGGTGAACTGGGGATTA
TGGGCACCGAGTTAAACTCTGAACTGGCGAAGGCAATGAAAGTTGATGCCCAACGTGGTGCATTCGTAAGCCAGGTCATG
CCGAACTCCTCAGCGGCGAAAGCAGGTATTAAAGCAGGTGATGTGATTACCTCTCTGAACGGTAAGCCGATCAGTAGCTT
TGCCGCACTGCGTGCTCAGGTTGGTACTATGCCTGTCGGTAGCAAACTGAGCCTTGGCTTACTGCGCGACGGCAAACCAG
TAACGGTGAATCTGGAGCTGCAGCAGAGCAGCCAGAATCAGGTTGATTCCAGCTCTATCTTCAACGGTATTGAAGGCGCT
GAGATGAGCAATAAGGGCAAAGATCAGGGCGTGGTAGTGAACAACGTGAAAACGGGCACCCCGGCTGCGCAGATCGGCCT
GAAGAAAGGTGATGTGATTATTGGTGCTAACCAGCAGGCAGTGAAAAACATTGCAGAGCTGCGTAAAATTCTCGACAGCA
AACCGTCTGTTCTGGCGCTGAACATTCAGCGTGGCGACAGCACTCTCTATCTGTTGATGCAGTAA

Upstream 100 bases:

>100_bases
TTTTACTTTTTGCAGAAACTTTAGTTCGGAACTTCGCGCTATAAAACGAATCTGAGGAACACAGCAATTTTGCGTTATCT
GTTAATCGAGACTGAAACAC

Downstream 100 bases:

>100_bases
TCCTCCACAGCCCCTTCCTGAAAAACAGGAAGGGGTTCCCTTTTATATAATGTGAAGCCCTCCACAACTCCATATTTCTT
CCTTCTCCTTTGTGCGATTG

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKKTTLALSALALSLGLALSPLSATAAEATPAASAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDDS
PFCQEGSPFQSSPFCQGGPGGNGGGQTQKFMSLGSGVIIDAEKGYVVTNNHVVDNANVIKVQLSDGRKFDAKMVGKDPRS
DIALIQIQNPKNLTAIKMADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGAL
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVM
PNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKLSLGLLRDGKPVTVNLELQQSSQNQVDSSSIFNGIEGA
EMSNKGKDQGVVVNNVKTGTPAAQIGLKKGDVIIGANQQAVKNIAELRKILDSKPSVLALNIQRGDSTLYLLMQ

Sequences:

>Translated_474_residues
MKKTTLALSALALSLGLALSPLSATAAEATPAASAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDDS
PFCQEGSPFQSSPFCQGGPGGNGGGQTQKFMSLGSGVIIDAEKGYVVTNNHVVDNANVIKVQLSDGRKFDAKMVGKDPRS
DIALIQIQNPKNLTAIKMADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGAL
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVM
PNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKLSLGLLRDGKPVTVNLELQQSSQNQVDSSSIFNGIEGA
EMSNKGKDQGVVVNNVKTGTPAAQIGLKKGDVIIGANQQAVKNIAELRKILDSKPSVLALNIQRGDSTLYLLMQ
>Mature_474_residues
MKKTTLALSALALSLGLALSPLSATAAEATPAASAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDDS
PFCQEGSPFQSSPFCQGGPGGNGGGQTQKFMSLGSGVIIDAEKGYVVTNNHVVDNANVIKVQLSDGRKFDAKMVGKDPRS
DIALIQIQNPKNLTAIKMADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGAL
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVM
PNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKLSLGLLRDGKPVTVNLELQQSSQNQVDSSSIFNGIEGA
EMSNKGKDQGVVVNNVKTGTPAAQIGLKKGDVIIGANQQAVKNIAELRKILDSKPSVLALNIQRGDSTLYLLMQ

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=248, Percent_Identity=41.9354838709677, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI22129776, Length=263, Percent_Identity=37.6425855513308, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=36.2903225806452, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI7019477, Length=267, Percent_Identity=35.5805243445693, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1786356, Length=474, Percent_Identity=96.2025316455696, Blast_Score=856, Evalue=0.0,
Organism=Escherichia coli, GI1789629, Length=479, Percent_Identity=57.2025052192067, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1789630, Length=279, Percent_Identity=42.2939068100358, Blast_Score=205, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24646839, Length=253, Percent_Identity=37.5494071146245, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49276; Mature: 49276

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTTLALSALALSLGLALSPLSATAAEATPAASAQQMPSLAPMLEKVMPSVVSINVEGS
CCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHCCHHHHHHHHHCCCEEEEEECCC
TTVNTPRMPRNFQQFFGDDSPFCQEGSPFQSSPFCQGGPGGNGGGQTQKFMSLGSGVIID
CEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEE
AEKGYVVTNNHVVDNANVIKVQLSDGRKFDAKMVGKDPRSDIALIQIQNPKNLTAIKMAD
CCCCEEEECCEEECCCCEEEEEECCCCEECCEECCCCCCCCEEEEEECCCCCEEEEEECC
SDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGAL
CCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNS
EEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
ELAKAMKVDAQRGAFVSQVMPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVG
HHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCC
SKLSLGLLRDGKPVTVNLELQQSSQNQVDSSSIFNGIEGAEMSNKGKDQGVVVNNVKTGT
CCCEEEEECCCCEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCCC
PAAQIGLKKGDVIIGANQQAVKNIAELRKILDSKPSVLALNIQRGDSTLYLLMQ
CHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MKKTTLALSALALSLGLALSPLSATAAEATPAASAQQMPSLAPMLEKVMPSVVSINVEGS
CCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHCCHHHHHHHHHCCCEEEEEECCC
TTVNTPRMPRNFQQFFGDDSPFCQEGSPFQSSPFCQGGPGGNGGGQTQKFMSLGSGVIID
CEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEE
AEKGYVVTNNHVVDNANVIKVQLSDGRKFDAKMVGKDPRSDIALIQIQNPKNLTAIKMAD
CCCCEEEECCEEECCCCEEEEEECCCCEECCEECCCCCCCCEEEEEECCCCCEEEEEECC
SDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGAL
CCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNS
EEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
ELAKAMKVDAQRGAFVSQVMPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVG
HHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCC
SKLSLGLLRDGKPVTVNLELQQSSQNQVDSSSIFNGIEGAEMSNKGKDQGVVVNNVKTGT
CCCEEEEECCCCEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCCC
PAAQIGLKKGDVIIGANQQAVKNIAELRKILDSKPSVLALNIQRGDSTLYLLMQ
CHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]