Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 218532518

GI number: 218532518

Start: 4909844

End: 4911829

Strand: Reverse

Name: mutL [H]

Synonym: Mchl_4632

Alternate gene names: 218532518

Gene position: 4911829-4909844 (Counterclockwise)

Preceding gene: 218532519

Following gene: 218532513

Centisome position: 85.01

GC content: 74.97

Gene sequence:

>1986_bases
ATGTCCGCCACCCCCGACCTTCGCGATCCGCCGCCCGCGCATGTGCGCCGCCTCGATCCGATCCTGGTCGATCGCATCGC
CGCGGGCGAGGTGGTCGAGCGGCCGGCCTCGGCGGTCAAGGAACTGGTCGAGAACGCGATCGATGCCGGCGCGCGCAGCA
TCGAGGTGGCGATCGAGGGCGGCGGGCGCCGCCTGATCCGCGTCATCGACGACGGCATCGGCATGGGGCCCGACGACCTC
GCGCTCGCGGTCGAGCGCCACGCCACGTCGAAGCTGCCCGACGGCGACCTGACCCGGATCGGCTCGCTCGGCTTTCGCGG
CGAGGCGCTGCCCTCGATCGGCGCGGTCTCGCGGCTCACGATCACCTCGCGCACCGCCGACGGCGAGGGGGTGAGCCTCA
CCCTCGATTCCGGCGTCAAGGGGCCGGTGCGCCCGGCGCCCGCCGCGCGCGGCACCCGCATCGAGGTCACCGAGCTGTTC
GCCGCGACCCCGGCCCGGCTGAAATTCCTGAAGACCGACCGGGCCGAGACGGCCGCCGTCTCCGAAATCCTGCGCCGGCT
CGCGGTGGCGCAGCCGCAGATCCGCTTCACCCTGCGCACCGAGAGCGGCAGCCCGACGGTGTTTCCCGCCGAGAGCGAGC
CGGGCCCGGCGGCCCTGCTGCGCCGGCTCGGAGCCGTGCTCGGCCCCGACTTCCCCGGCAATGCCGTGCCCGTCGACATG
GCCCGCGAGGGCTTCGCGCTTGCCGGCCATGTCGGCCTGCCGACCTTCCACCGCGGGGCGGCGAGCCACATCTACTTCGT
CGTCAACGGGCGCCCGGTGCGCGACCGGCTCCTGCTCGGGGCCGTGCGCGGAGCTTATGCCGACACCATGAGCTCCGACC
GCCACCCGGTGCTCGCGCTCCATCTCACCTGCGATCCCGCCCTCGTCGATGTGAACGTGCACCCGGCCAAGACCGAGCTG
CGCTTCCGCGAGCCGGGGCTGGTGCGAGCGCTGATCGTCAGCGCGATCCACGAGGCTTTGCGCCGGGCTGGCGCCCGGTC
TTCCAGCACGGGCACCCAGGCCGCCCTCGACGCGCTGCGGGCCGGCGCCGGCATGGGGGGCGCCCCGCCGATGGCGGGGG
TGGGCCGGTTCGCCGTGCATTCGGGCGCCTCCACTGCCAGCGCCCTGAACCCCCGCCCGGCGAGCCGCCTGTTCTCCGGC
CCCTCGGTGGCCGCACCCGCGGGCTACCGCCCGGCGCTGCGCCCGGCCTTCACCGAGGACCATCCAGGCTTTGCCGAGAC
GCCGCAGGCTTTGTTCTCCGCCGACCTCGCCCCGCCCGGCGCCGACCTGCGGCCCGATCCGGAGGCGGGCTCGGAGGCCG
AGACCCATCCCGAGACCCACCCGCTGGGTGCCGCCCGCGCGCAGATCCACGAAACCTACATCGTCGCCCAGACCCGCGAT
GGGATCGTGCTGGTCGATCAGCACGCCGCCCACGAGCGGCTCGTCTACGAGCGGCTGAAGCGCGAGCGGGCCGGCGGCGG
CGTGCTCGCCCAGGGGCTCCTGATCCCCGACGTGGTCGAGATGGCGCCCGAGGAGGCCGACCGCCTCGTCGAGGCGGCGC
CCGAGCTGGAGCGGCTGGGCCTCACCCTGGAGGCGTTCGGCCCCGGCGCCGTGCTGGTGCGCTCGGTGCCGTCGGCGCTC
GCGGGCGGCTCGGTGAAGGGGCTCGTGCTCGACGTGCTCGACGCGTTGGCGGCCAGCGGCGTCGAGGAGGGCGGCCCGGC
CGGCGCGGGCGATCCCGATCCGGTGAGCCGGCGCCTCGACGCGATCCTCTCGCGGATGAGCTGCCACGGCTCGATCCGCG
CCGGCCGCCGCCTCAAGCCGGAGGAGATGAACGCCCTGCTGCGCGAGATGGAGGCGACGCCGCTCTCCGGCTCGTGCAAC
CACGGCCGCCCGACCTTCGTGAGCCTCGGACTCGCCGATATCGAGCGGCTGTTCGGGCGGCGGTGA

Upstream 100 bases:

>100_bases
ACCTCAGGGTGAGGCCGAGCCGGGAGTGAGGGAGAGGCTGTTCGCAAACGTCCGCCTTCGCCTATCGGGCGGGCGGCAGG
CCGCCTATATTTCGCGAGCC

Downstream 100 bases:

>100_bases
CGGCGTCCTCCTCAGGAAGACGCCGGGCTCGGGCGTAAAGCCGGCAGGACGCCGCCCCGCGGTCAGGCTGGGATGGCGAC
CGCCAGGGCCGCCGCGCTCG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MSATPDLRDPPPAHVRRLDPILVDRIAAGEVVERPASAVKELVENAIDAGARSIEVAIEGGGRRLIRVIDDGIGMGPDDL
ALAVERHATSKLPDGDLTRIGSLGFRGEALPSIGAVSRLTITSRTADGEGVSLTLDSGVKGPVRPAPAARGTRIEVTELF
AATPARLKFLKTDRAETAAVSEILRRLAVAQPQIRFTLRTESGSPTVFPAESEPGPAALLRRLGAVLGPDFPGNAVPVDM
AREGFALAGHVGLPTFHRGAASHIYFVVNGRPVRDRLLLGAVRGAYADTMSSDRHPVLALHLTCDPALVDVNVHPAKTEL
RFREPGLVRALIVSAIHEALRRAGARSSSTGTQAALDALRAGAGMGGAPPMAGVGRFAVHSGASTASALNPRPASRLFSG
PSVAAPAGYRPALRPAFTEDHPGFAETPQALFSADLAPPGADLRPDPEAGSEAETHPETHPLGAARAQIHETYIVAQTRD
GIVLVDQHAAHERLVYERLKRERAGGGVLAQGLLIPDVVEMAPEEADRLVEAAPELERLGLTLEAFGPGAVLVRSVPSAL
AGGSVKGLVLDVLDALAASGVEEGGPAGAGDPDPVSRRLDAILSRMSCHGSIRAGRRLKPEEMNALLREMEATPLSGSCN
HGRPTFVSLGLADIERLFGRR

Sequences:

>Translated_661_residues
MSATPDLRDPPPAHVRRLDPILVDRIAAGEVVERPASAVKELVENAIDAGARSIEVAIEGGGRRLIRVIDDGIGMGPDDL
ALAVERHATSKLPDGDLTRIGSLGFRGEALPSIGAVSRLTITSRTADGEGVSLTLDSGVKGPVRPAPAARGTRIEVTELF
AATPARLKFLKTDRAETAAVSEILRRLAVAQPQIRFTLRTESGSPTVFPAESEPGPAALLRRLGAVLGPDFPGNAVPVDM
AREGFALAGHVGLPTFHRGAASHIYFVVNGRPVRDRLLLGAVRGAYADTMSSDRHPVLALHLTCDPALVDVNVHPAKTEL
RFREPGLVRALIVSAIHEALRRAGARSSSTGTQAALDALRAGAGMGGAPPMAGVGRFAVHSGASTASALNPRPASRLFSG
PSVAAPAGYRPALRPAFTEDHPGFAETPQALFSADLAPPGADLRPDPEAGSEAETHPETHPLGAARAQIHETYIVAQTRD
GIVLVDQHAAHERLVYERLKRERAGGGVLAQGLLIPDVVEMAPEEADRLVEAAPELERLGLTLEAFGPGAVLVRSVPSAL
AGGSVKGLVLDVLDALAASGVEEGGPAGAGDPDPVSRRLDAILSRMSCHGSIRAGRRLKPEEMNALLREMEATPLSGSCN
HGRPTFVSLGLADIERLFGRR
>Mature_660_residues
SATPDLRDPPPAHVRRLDPILVDRIAAGEVVERPASAVKELVENAIDAGARSIEVAIEGGGRRLIRVIDDGIGMGPDDLA
LAVERHATSKLPDGDLTRIGSLGFRGEALPSIGAVSRLTITSRTADGEGVSLTLDSGVKGPVRPAPAARGTRIEVTELFA
ATPARLKFLKTDRAETAAVSEILRRLAVAQPQIRFTLRTESGSPTVFPAESEPGPAALLRRLGAVLGPDFPGNAVPVDMA
REGFALAGHVGLPTFHRGAASHIYFVVNGRPVRDRLLLGAVRGAYADTMSSDRHPVLALHLTCDPALVDVNVHPAKTELR
FREPGLVRALIVSAIHEALRRAGARSSSTGTQAALDALRAGAGMGGAPPMAGVGRFAVHSGASTASALNPRPASRLFSGP
SVAAPAGYRPALRPAFTEDHPGFAETPQALFSADLAPPGADLRPDPEAGSEAETHPETHPLGAARAQIHETYIVAQTRDG
IVLVDQHAAHERLVYERLKRERAGGGVLAQGLLIPDVVEMAPEEADRLVEAAPELERLGLTLEAFGPGAVLVRSVPSALA
GGSVKGLVLDVLDALAASGVEEGGPAGAGDPDPVSRRLDAILSRMSCHGSIRAGRRLKPEEMNALLREMEATPLSGSCNH
GRPTFVSLGLADIERLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=318, Percent_Identity=36.1635220125786, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI310128478, Length=351, Percent_Identity=28.2051282051282, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=28, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4505911, Length=341, Percent_Identity=28.7390029325513, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI189458898, Length=341, Percent_Identity=28.7390029325513, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI310128480, Length=311, Percent_Identity=26.0450160771704, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI189458896, Length=333, Percent_Identity=27.9279279279279, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI263191589, Length=224, Percent_Identity=30.3571428571429, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=581, Percent_Identity=35.4561101549053, Blast_Score=258, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71991825, Length=329, Percent_Identity=34.9544072948328, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=371, Percent_Identity=26.4150943396226, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323819, Length=357, Percent_Identity=31.3725490196078, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324247, Length=342, Percent_Identity=26.0233918128655, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=740, Percent_Identity=22.4324324324324, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17136968, Length=345, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17136970, Length=370, Percent_Identity=26.2162162162162, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 69154; Mature: 69022

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATPDLRDPPPAHVRRLDPILVDRIAAGEVVERPASAVKELVENAIDAGARSIEVAIEG
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GGRRLIRVIDDGIGMGPDDLALAVERHATSKLPDGDLTRIGSLGFRGEALPSIGAVSRLT
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEE
ITSRTADGEGVSLTLDSGVKGPVRPAPAARGTRIEVTELFAATPARLKFLKTDRAETAAV
EEECCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHCCHHHHEEHHCCCHHHHHH
SEILRRLAVAQPQIRFTLRTESGSPTVFPAESEPGPAALLRRLGAVLGPDFPGNAVPVDM
HHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEHHH
AREGFALAGHVGLPTFHRGAASHIYFVVNGRPVRDRLLLGAVRGAYADTMSSDRHPVLAL
CCCCCEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
HLTCDPALVDVNVHPAKTELRFREPGLVRALIVSAIHEALRRAGARSSSTGTQAALDALR
EEECCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AGAGMGGAPPMAGVGRFAVHSGASTASALNPRPASRLFSGPSVAAPAGYRPALRPAFTED
HCCCCCCCCCCCCCCHHHHCCCCCHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
HPGFAETPQALFSADLAPPGADLRPDPEAGSEAETHPETHPLGAARAQIHETYIVAQTRD
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHEEEEEEECCC
GIVLVDQHAAHERLVYERLKRERAGGGVLAQGLLIPDVVEMAPEEADRLVEAAPELERLG
CEEEEECCHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHCHHHHHHHHHHCCCHHHHC
LTLEAFGPGAVLVRSVPSALAGGSVKGLVLDVLDALAASGVEEGGPAGAGDPDPVSRRLD
CEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
AILSRMSCHGSIRAGRRLKPEEMNALLREMEATPLSGSCNHGRPTFVSLGLADIERLFGR
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHCC
R
C
>Mature Secondary Structure 
SATPDLRDPPPAHVRRLDPILVDRIAAGEVVERPASAVKELVENAIDAGARSIEVAIEG
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GGRRLIRVIDDGIGMGPDDLALAVERHATSKLPDGDLTRIGSLGFRGEALPSIGAVSRLT
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEE
ITSRTADGEGVSLTLDSGVKGPVRPAPAARGTRIEVTELFAATPARLKFLKTDRAETAAV
EEECCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHCCHHHHEEHHCCCHHHHHH
SEILRRLAVAQPQIRFTLRTESGSPTVFPAESEPGPAALLRRLGAVLGPDFPGNAVPVDM
HHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEHHH
AREGFALAGHVGLPTFHRGAASHIYFVVNGRPVRDRLLLGAVRGAYADTMSSDRHPVLAL
CCCCCEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
HLTCDPALVDVNVHPAKTELRFREPGLVRALIVSAIHEALRRAGARSSSTGTQAALDALR
EEECCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AGAGMGGAPPMAGVGRFAVHSGASTASALNPRPASRLFSGPSVAAPAGYRPALRPAFTED
HCCCCCCCCCCCCCCHHHHCCCCCHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
HPGFAETPQALFSADLAPPGADLRPDPEAGSEAETHPETHPLGAARAQIHETYIVAQTRD
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHEEEEEEECCC
GIVLVDQHAAHERLVYERLKRERAGGGVLAQGLLIPDVVEMAPEEADRLVEAAPELERLG
CEEEEECCHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHCHHHHHHHHHHCCCHHHHC
LTLEAFGPGAVLVRSVPSALAGGSVKGLVLDVLDALAASGVEEGGPAGAGDPDPVSRRLD
CEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
AILSRMSCHGSIRAGRRLKPEEMNALLREMEATPLSGSCNHGRPTFVSLGLADIERLFGR
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]