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The map label for this gene is tmk [H]

Identifier: 218532450

GI number: 218532450

Start: 4830008

End: 4830742

Strand: Reverse

Name: tmk [H]

Synonym: Mchl_4562

Alternate gene names: 218532450

Gene position: 4830742-4830008 (Counterclockwise)

Preceding gene: 218532451

Following gene: 218532449

Centisome position: 83.61

GC content: 72.52

Gene sequence:

>735_bases
ATGTCGAGCGATGCGCCGCGGGGCGTCTTCATCACCTTCGAGGGCGGGGAGGGGGCGGGCAAGTCCACCCAGATCGCGCG
CTTGGCCGAGACCCTGCGCAGGGTGAGCGGGCGCGAAGTCGTGACCACCCGCGAGCCCGGCGGGACGGAACGGGCGGAAG
CCCTGCGTGCGGCTTTGCTGCGGGGCGTGGCCAAGCCCTACGGGCCCTTCGCCGAAGCGCTGATGTTCGCCGCCGCCCGC
ATCGACCACATCGAGAACTTGATCCGCCCGGCCCTGGACCGCGGCGCGATCGTACTGTGCGACCGCTTCTCCGACTCGAC
CCGCGCCTATCAGGGCGCGGCCGGCGGCCTGGATCCGGCGCTGATCGACAGCCTGGAGCGGGTAACGCTCGTGGATTTGC
GCCCCGACCTTACCCTGATCCTCGATCTGCCGCCCGAGGCCGGCCTCGCCCGGGCGCGGCGGCGCGGGGCGGGCGAACCC
GCCGACCGCTTCGAAGCCGAGGGCATGCGTTTCCACGAGCGGCTGCGGACGGCCTTCCGCAGCATCGCCGAGGCCGAGCC
GGAGCGCTGCCGCGTCATCGACGCGGATCTCGGCCCCGATGCGGTCGAGACCGCCATCGCCACCGCCATCGCCGCCCGAT
GGCCGGATCTGCTGCCCCCCGCGGGAGAAGGGCAGGGGCAAGAGGGTAAGAACCGGGAGGGCAAGGACCGGGAAGGACAA
GGTCATGCGGCCTGA

Upstream 100 bases:

>100_bases
GGGCGCCTCCTGGCTCACGGGACGCAAGGGCGCCATGGCCGACTAGGGCGCGCGGCTGATTAGGTCGCGCCCCGCCGCCT
ACTGTGCTAGCCCGCAATCC

Downstream 100 bases:

>100_bases
TTCCGCCCGGACCGCCCGCGATGCCCGCACCGAGGCCGAGGCGGGCGACCTCGCCCACGTCCCGCGCCCGCGCGAACAGA
CCCGCCTTTTCGGGCATGGT

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSSDAPRGVFITFEGGEGAGKSTQIARLAETLRRVSGREVVTTREPGGTERAEALRAALLRGVAKPYGPFAEALMFAAAR
IDHIENLIRPALDRGAIVLCDRFSDSTRAYQGAAGGLDPALIDSLERVTLVDLRPDLTLILDLPPEAGLARARRRGAGEP
ADRFEAEGMRFHERLRTAFRSIAEAEPERCRVIDADLGPDAVETAIATAIAARWPDLLPPAGEGQGQEGKNREGKDREGQ
GHAA

Sequences:

>Translated_244_residues
MSSDAPRGVFITFEGGEGAGKSTQIARLAETLRRVSGREVVTTREPGGTERAEALRAALLRGVAKPYGPFAEALMFAAAR
IDHIENLIRPALDRGAIVLCDRFSDSTRAYQGAAGGLDPALIDSLERVTLVDLRPDLTLILDLPPEAGLARARRRGAGEP
ADRFEAEGMRFHERLRTAFRSIAEAEPERCRVIDADLGPDAVETAIATAIAARWPDLLPPAGEGQGQEGKNREGKDREGQ
GHAA
>Mature_243_residues
SSDAPRGVFITFEGGEGAGKSTQIARLAETLRRVSGREVVTTREPGGTERAEALRAALLRGVAKPYGPFAEALMFAAARI
DHIENLIRPALDRGAIVLCDRFSDSTRAYQGAAGGLDPALIDSLERVTLVDLRPDLTLILDLPPEAGLARARRRGAGEPA
DRFEAEGMRFHERLRTAFRSIAEAEPERCRVIDADLGPDAVETAIATAIAARWPDLLPPAGEGQGQEGKNREGKDREGQG
HAA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=211, Percent_Identity=43.1279620853081, Blast_Score=141, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 26172; Mature: 26041

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDAPRGVFITFEGGEGAGKSTQIARLAETLRRVSGREVVTTREPGGTERAEALRAALL
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
RGVAKPYGPFAEALMFAAARIDHIENLIRPALDRGAIVLCDRFSDSTRAYQGAAGGLDPA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCHH
LIDSLERVTLVDLRPDLTLILDLPPEAGLARARRRGAGEPADRFEAEGMRFHERLRTAFR
HHHHHHHEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SIAEAEPERCRVIDADLGPDAVETAIATAIAARWPDLLPPAGEGQGQEGKNREGKDREGQ
HHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GHAA
CCCC
>Mature Secondary Structure 
SSDAPRGVFITFEGGEGAGKSTQIARLAETLRRVSGREVVTTREPGGTERAEALRAALL
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
RGVAKPYGPFAEALMFAAARIDHIENLIRPALDRGAIVLCDRFSDSTRAYQGAAGGLDPA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCHH
LIDSLERVTLVDLRPDLTLILDLPPEAGLARARRRGAGEPADRFEAEGMRFHERLRTAFR
HHHHHHHEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SIAEAEPERCRVIDADLGPDAVETAIATAIAARWPDLLPPAGEGQGQEGKNREGKDREGQ
HHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GHAA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA