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The map label for this gene is irlR [H]

Identifier: 218532370

GI number: 218532370

Start: 4743858

End: 4744523

Strand: Reverse

Name: irlR [H]

Synonym: Mchl_4482

Alternate gene names: 218532370

Gene position: 4744523-4743858 (Counterclockwise)

Preceding gene: 218532371

Following gene: 218532369

Centisome position: 82.11

GC content: 74.77

Gene sequence:

>666_bases
ATGCGCATCCTCGTCGTAGAAGACGAGCCGCGCATCGCGGCCGATATCAGCGAGGGTCTGGAGCGGGCCGGCTACGTCGC
CGAGATCGTCGGCGACGGCGAGGCGGCGTGGTTCCGGGCCGAGACCGAGACCTACGACGCCATGGTGCTCGACCTCGGCC
TGCCCCGCCTCGACGGGCTGGGCGTGCTGCGCCGCCTGCGCGGAGCCGACGTGGCGCTCCCGGTGCTGATCCTCACCGCC
CGCGACGGCTGGCGCGAGCGGGTCGAGGGGATCGACGCGGGCGCCGACGACTACCTCGTCAAGCCGTTCCGGATGGAGGA
GCTGGTGGCGCGGCTGCGCGCCATCCTGCGCCGCACCGCCGGCCACGCCTCCCCCGTCCTGCGGGCCGGCGCGGTCGAAC
TCGACACCCGCACCCGCGCGGTCTCGGTGGCGGGCCGCGAGACGGATCTCACCGCGCTCGAATACCGCCTGCTCGCCTTC
CTGCTCCACCGCCAGGGGCAGGTCGTGGCGGCGGGCGAGCTGCTCGACCACCTCCACGGCAGCGACAGCGACCGCGAGGC
CAACGCGCTGGAGGCCCTGCTGACCCGGCTGCGGCGCAAGCTCGGCCCCGGCATCATCGAGACCCGCCGCGGCCACGGCT
ACCTCGTGCCGTCCGACCCGCCGTGA

Upstream 100 bases:

>100_bases
CACCGACGGGCGCCGCCGCGACGTGAAGATCGATGCCAGCTCCCTCAAGCTCCTCGACGTGGACGACGATGATTGAGGTC
CGCGCGCTTCCGGGGACGAC

Downstream 100 bases:

>100_bases
ACAGCGGCTCGCTGCGCCTGCGGCTCGGGCTCGCCGCCGCCGGGCTGATTGCCCTGGCGCTGGTGCTGGCCGGGATCGGG
CTGACGCTGATCTTCGATCG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRILVVEDEPRIAADISEGLERAGYVAEIVGDGEAAWFRAETETYDAMVLDLGLPRLDGLGVLRRLRGADVALPVLILTA
RDGWRERVEGIDAGADDYLVKPFRMEELVARLRAILRRTAGHASPVLRAGAVELDTRTRAVSVAGRETDLTALEYRLLAF
LLHRQGQVVAAGELLDHLHGSDSDREANALEALLTRLRRKLGPGIIETRRGHGYLVPSDPP

Sequences:

>Translated_221_residues
MRILVVEDEPRIAADISEGLERAGYVAEIVGDGEAAWFRAETETYDAMVLDLGLPRLDGLGVLRRLRGADVALPVLILTA
RDGWRERVEGIDAGADDYLVKPFRMEELVARLRAILRRTAGHASPVLRAGAVELDTRTRAVSVAGRETDLTALEYRLLAF
LLHRQGQVVAAGELLDHLHGSDSDREANALEALLTRLRRKLGPGIIETRRGHGYLVPSDPP
>Mature_221_residues
MRILVVEDEPRIAADISEGLERAGYVAEIVGDGEAAWFRAETETYDAMVLDLGLPRLDGLGVLRRLRGADVALPVLILTA
RDGWRERVEGIDAGADDYLVKPFRMEELVARLRAILRRTAGHASPVLRAGAVELDTRTRAVSVAGRETDLTALEYRLLAF
LLHRQGQVVAAGELLDHLHGSDSDREANALEALLTRLRRKLGPGIIETRRGHGYLVPSDPP

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=37.8995433789954, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1789402, Length=214, Percent_Identity=42.5233644859813, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=40.1826484018265, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=36.1990950226244, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=37.4429223744292, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=35.6164383561644, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=36.322869955157, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=32.7272727272727, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=31.304347826087, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.6521739130435, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788394, Length=208, Percent_Identity=32.6923076923077, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=28, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=29.1845493562232, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.3913043478261, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788713, Length=133, Percent_Identity=27.8195488721804, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24270; Mature: 24270

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDEPRIAADISEGLERAGYVAEIVGDGEAAWFRAETETYDAMVLDLGLPRLDGL
CEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHEEEEECCCCCCCHH
GVLRRLRGADVALPVLILTARDGWRERVEGIDAGADDYLVKPFRMEELVARLRAILRRTA
HHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHC
GHASPVLRAGAVELDTRTRAVSVAGRETDLTALEYRLLAFLLHRQGQVVAAGELLDHLHG
CCCCHHHHCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCC
SDSDREANALEALLTRLRRKLGPGIIETRRGHGYLVPSDPP
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCC
>Mature Secondary Structure
MRILVVEDEPRIAADISEGLERAGYVAEIVGDGEAAWFRAETETYDAMVLDLGLPRLDGL
CEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHEEEEECCCCCCCHH
GVLRRLRGADVALPVLILTARDGWRERVEGIDAGADDYLVKPFRMEELVARLRAILRRTA
HHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHC
GHASPVLRAGAVELDTRTRAVSVAGRETDLTALEYRLLAFLLHRQGQVVAAGELLDHLHG
CCCCHHHHCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCC
SDSDREANALEALLTRLRRKLGPGIIETRRGHGYLVPSDPP
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]