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The map label for this gene is phoQ [H]

Identifier: 218532369

GI number: 218532369

Start: 4742515

End: 4743861

Strand: Reverse

Name: phoQ [H]

Synonym: Mchl_4481

Alternate gene names: 218532369

Gene position: 4743861-4742515 (Counterclockwise)

Preceding gene: 218532370

Following gene: 218532367

Centisome position: 82.1

GC content: 75.58

Gene sequence:

>1347_bases
GTGAACAGCGGCTCGCTGCGCCTGCGGCTCGGGCTCGCCGCCGCCGGGCTGATTGCCCTGGCGCTGGTGCTGGCCGGGAT
CGGGCTGACGCTGATCTTCGATCGGGTGCTCGACGCGCGCACCGCCGACGGCCTCGACCGCACCGCCAAGCTCATCGCCG
GGCAGGTCGCCCTGGCGCCGGACGGGGCCCCGACCCTGCCGCGCGAGCCGCCGGATTCACGCTTCTCGACGCCCTATGGC
GGCCTCTACTGGCAAGTGGAGCGTGCCGGCGGCACCGCCCTGCGCTCGCGCTCGCTCTGGGACCGGGGCCTCGGCACGTT
GCCCGACACGTCCGAGGAGCCGGCGGTGGGCGACCTCGCCGGGCCGGATGGCGGCCGGCTCATCGCCGTGACCCGGCGGG
TCTCGATTCCGGGCAACGGCGGCACGGTGGCGCTCGCCGTCACGGTGGCCGAGGACCGCCGCGACCTCGCCCAGAGCCGC
GCGACCTTCCTGCGCCTGCTGGTGCCCTCGCTCGGCGCGCTGTTCGCGGCGCTGACGCTCGCCATGTCGCTGTTCGTGCG
CCGGGCGCTGGCGCCCTTCCGGACCCTGCGGGCGGATCTCGCCGCGATCCATGCCGGAACGCAGGCGCGGCTGCCCGACA
CCTTCCCCGAGGAGGTGCGCCCGCTGGTGGCCGACCTCAACCGCCTGCTCGACGCGCAGGAGCGCGACCTCGAGCGGGCG
CGCACGGGTGCCGGCGACATGGCCCACGGCCTCAAGACCCCGCTCGCGGTGCTCGACGCGCTGGCCCGCCGCACGGAAGC
CGCCGACCCTGCGCTCGCGGCCGAGATCGCCGAGCAGGCGCACGCCATGGGCCGGCAGGTCGAGCGCACGCTCGCCCGGG
CGCGGGCGGCCTCGGGCGGCCTGCGGCGGCGCGCCTGCCCGGTCGGACCGGCCATTGCGCGGATTGTCGGTGCACTGAAA
CGGCTCCCCGAGGGGGAATCCCTACGCTGGGAGATCGCAGTCCCGGAAAACCTCGCCTTTCCCGGCGACGAGGGCGACCT
CACCGAGATCCTGGGCAACCTCCTCGACAACGCCCGCAAATGGGCCCACCGCCGCATCCGCGTCTCGGGAGGCGCGGAGG
GCGGCGAACACCGTCTGGTGTTGGAGGATGACGGCCCCGGCATGAGCGAGGCGGCGATCGCCGGCATCGCCCGCGGCCGG
CGCTGGGACGAGAGTCGGCCCGGCACCGGCTTCGGCATCGCCATCGCCCGCGACCTCGCGGAGGGCGTCGGCGCGCGGAT
GCACCTCAGCCGCTCCGAACTCGGCGGCCTGCGGGTGGAGATGCGCTGGCCGGTTCCAGCAGCCTGA

Upstream 100 bases:

>100_bases
ACGCGCTGGAGGCCCTGCTGACCCGGCTGCGGCGCAAGCTCGGCCCCGGCATCATCGAGACCCGCCGCGGCCACGGCTAC
CTCGTGCCGTCCGACCCGCC

Downstream 100 bases:

>100_bases
GGCCGGCGCCGGAGCGATGCCGTCAGGCGGCCCGGCCGAGGGCGCCGAGCAGGTCGGAGCGGCCATAGGGCTTCGGCAGG
AAGCCCGCATCGGGCAGGTC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNSGSLRLRLGLAAAGLIALALVLAGIGLTLIFDRVLDARTADGLDRTAKLIAGQVALAPDGAPTLPREPPDSRFSTPYG
GLYWQVERAGGTALRSRSLWDRGLGTLPDTSEEPAVGDLAGPDGGRLIAVTRRVSIPGNGGTVALAVTVAEDRRDLAQSR
ATFLRLLVPSLGALFAALTLAMSLFVRRALAPFRTLRADLAAIHAGTQARLPDTFPEEVRPLVADLNRLLDAQERDLERA
RTGAGDMAHGLKTPLAVLDALARRTEAADPALAAEIAEQAHAMGRQVERTLARARAASGGLRRRACPVGPAIARIVGALK
RLPEGESLRWEIAVPENLAFPGDEGDLTEILGNLLDNARKWAHRRIRVSGGAEGGEHRLVLEDDGPGMSEAAIAGIARGR
RWDESRPGTGFGIAIARDLAEGVGARMHLSRSELGGLRVEMRWPVPAA

Sequences:

>Translated_448_residues
MNSGSLRLRLGLAAAGLIALALVLAGIGLTLIFDRVLDARTADGLDRTAKLIAGQVALAPDGAPTLPREPPDSRFSTPYG
GLYWQVERAGGTALRSRSLWDRGLGTLPDTSEEPAVGDLAGPDGGRLIAVTRRVSIPGNGGTVALAVTVAEDRRDLAQSR
ATFLRLLVPSLGALFAALTLAMSLFVRRALAPFRTLRADLAAIHAGTQARLPDTFPEEVRPLVADLNRLLDAQERDLERA
RTGAGDMAHGLKTPLAVLDALARRTEAADPALAAEIAEQAHAMGRQVERTLARARAASGGLRRRACPVGPAIARIVGALK
RLPEGESLRWEIAVPENLAFPGDEGDLTEILGNLLDNARKWAHRRIRVSGGAEGGEHRLVLEDDGPGMSEAAIAGIARGR
RWDESRPGTGFGIAIARDLAEGVGARMHLSRSELGGLRVEMRWPVPAA
>Mature_448_residues
MNSGSLRLRLGLAAAGLIALALVLAGIGLTLIFDRVLDARTADGLDRTAKLIAGQVALAPDGAPTLPREPPDSRFSTPYG
GLYWQVERAGGTALRSRSLWDRGLGTLPDTSEEPAVGDLAGPDGGRLIAVTRRVSIPGNGGTVALAVTVAEDRRDLAQSR
ATFLRLLVPSLGALFAALTLAMSLFVRRALAPFRTLRADLAAIHAGTQARLPDTFPEEVRPLVADLNRLLDAQERDLERA
RTGAGDMAHGLKTPLAVLDALARRTEAADPALAAEIAEQAHAMGRQVERTLARARAASGGLRRRACPVGPAIARIVGALK
RLPEGESLRWEIAVPENLAFPGDEGDLTEILGNLLDNARKWAHRRIRVSGGAEGGEHRLVLEDDGPGMSEAAIAGIARGR
RWDESRPGTGFGIAIARDLAEGVGARMHLSRSELGGLRVEMRWPVPAA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=258, Percent_Identity=31.3953488372093, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788393, Length=270, Percent_Identity=24.8148148148148, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=213, Percent_Identity=27.6995305164319, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47430; Mature: 47430

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGSLRLRLGLAAAGLIALALVLAGIGLTLIFDRVLDARTADGLDRTAKLIAGQVALAP
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECC
DGAPTLPREPPDSRFSTPYGGLYWQVERAGGTALRSRSLWDRGLGTLPDTSEEPAVGDLA
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GPDGGRLIAVTRRVSIPGNGGTVALAVTVAEDRRDLAQSRATFLRLLVPSLGALFAALTL
CCCCCEEEEEEEEEECCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMSLFVRRALAPFRTLRADLAAIHAGTQARLPDTFPEEVRPLVADLNRLLDAQERDLERA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
RTGAGDMAHGLKTPLAVLDALARRTEAADPALAAEIAEQAHAMGRQVERTLARARAASGG
HCCCCHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LRRRACPVGPAIARIVGALKRLPEGESLRWEIAVPENLAFPGDEGDLTEILGNLLDNARK
CCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
WAHRRIRVSGGAEGGEHRLVLEDDGPGMSEAAIAGIARGRRWDESRPGTGFGIAIARDLA
HHHHEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
EGVGARMHLSRSELGGLRVEMRWPVPAA
HHCCCEEEECHHHHCCEEEEEECCCCCC
>Mature Secondary Structure
MNSGSLRLRLGLAAAGLIALALVLAGIGLTLIFDRVLDARTADGLDRTAKLIAGQVALAP
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECC
DGAPTLPREPPDSRFSTPYGGLYWQVERAGGTALRSRSLWDRGLGTLPDTSEEPAVGDLA
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GPDGGRLIAVTRRVSIPGNGGTVALAVTVAEDRRDLAQSRATFLRLLVPSLGALFAALTL
CCCCCEEEEEEEEEECCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMSLFVRRALAPFRTLRADLAAIHAGTQARLPDTFPEEVRPLVADLNRLLDAQERDLERA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
RTGAGDMAHGLKTPLAVLDALARRTEAADPALAAEIAEQAHAMGRQVERTLARARAASGG
HCCCCHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LRRRACPVGPAIARIVGALKRLPEGESLRWEIAVPENLAFPGDEGDLTEILGNLLDNARK
CCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
WAHRRIRVSGGAEGGEHRLVLEDDGPGMSEAAIAGIARGRRWDESRPGTGFGIAIARDLA
HHHHEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
EGVGARMHLSRSELGGLRVEMRWPVPAA
HHCCCEEEECHHHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA