BacMap

Definition	Methylobacterium chloromethanicum CM4, complete genome.
Accession	NC_011757
Length	5,777,908

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The map label for this gene is yciK [H]

Identifier: 218532187

GI number: 218532187

Start: 4539971

End: 4540714

Strand: Reverse

Name: yciK [H]

Synonym: Mchl_4299

Alternate gene names: 218532187

Gene position: 4540714-4539971 (Counterclockwise)

Preceding gene: 218532188

Following gene: 218532186

Centisome position: 78.59

GC content: 71.1

Gene sequence:

>744_bases
ATGGCCGACAAAATCCTCGACGGTCGGGTGGCCGTCGTCACCGGCGCCTCCCGCGGCATCGGCCGCGCCGCCGCCCTGGC
CCTCGCGGAAGCCGGCGCCCATGTCGTCGCGGTCGCCCGCACGCAGGGCGGCCTGGAGGAACTCGACGACGCGATCCGCT
CCGCCGGCGGCCACGCGACGCTCGTGCCGCTCGATCTGACCGATTACGACGCCATCGACCGCCTGGGTGCGGCGCTCAAC
GAACGCTGGGGCCGGCTCGACGCGGTGGTCGGCAATGCCGGCATCCTCGGCAACCTGATGCCGGTCAGCCACGTCACGCC
GAAGGTCTGGGATCAGGTGATGGCGATCAACGTCACCGCCAACTGGCGCCTGATCCGTTCGTTCGACCCGCTGCTCCAGC
GCTCGGATGCGGGACGCGCGATCTTCGTCTCCTCGGGCGCGGCCGCGAAATGCCGGGCCTATTGGGGGCCCTATTCCGTC
TCGAAGGCGGCGCTGGAGGCGATGGTGCGCACCTACGCCGCCGAGAACGAGAGCACGGGCGTGCGCGCCATGCTGCTCAA
CCCCGGCCCGCTGCGCACGGGCATGCGCGCGGCGGCGATGCCGGGCGAGGATCCGGCGACGCTCAAGACCCCGGAGGAGC
TGGCGCCGCATTTCGTGCGCCTCGCCTCCCCCGCATGGAACGAGACGGGCAAACTCTACGATTTCCCCAGCGACCGGGTT
CTCGCCTTCTCCGCACCCCAGTAA

Upstream 100 bases:

>100_bases
CCGACCATTGCTTCACCGGCGACTACCCGACCGGCCTGACCGATCTGGCGATCGCCGGGCCCAAGCGCTTCGCCATGCTG
GCCGAGGCGGACTGAAGTCG

Downstream 100 bases:

>100_bases
CGGGGTCCGGGGCCAAGGCCCCGGCGGGTTTACGGGCAGAGCCCGCTTTCTTTGTTTTCCAGGTTTCGCGCCATGATCGA
CGTTCGCTGCATCTGCGCCA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MADKILDGRVAVVTGASRGIGRAAALALAEAGAHVVAVARTQGGLEELDDAIRSAGGHATLVPLDLTDYDAIDRLGAALN
ERWGRLDAVVGNAGILGNLMPVSHVTPKVWDQVMAINVTANWRLIRSFDPLLQRSDAGRAIFVSSGAAAKCRAYWGPYSV
SKAALEAMVRTYAAENESTGVRAMLLNPGPLRTGMRAAAMPGEDPATLKTPEELAPHFVRLASPAWNETGKLYDFPSDRV
LAFSAPQ

Sequences:

>Translated_247_residues
MADKILDGRVAVVTGASRGIGRAAALALAEAGAHVVAVARTQGGLEELDDAIRSAGGHATLVPLDLTDYDAIDRLGAALN
ERWGRLDAVVGNAGILGNLMPVSHVTPKVWDQVMAINVTANWRLIRSFDPLLQRSDAGRAIFVSSGAAAKCRAYWGPYSV
SKAALEAMVRTYAAENESTGVRAMLLNPGPLRTGMRAAAMPGEDPATLKTPEELAPHFVRLASPAWNETGKLYDFPSDRV
LAFSAPQ
>Mature_246_residues
ADKILDGRVAVVTGASRGIGRAAALALAEAGAHVVAVARTQGGLEELDDAIRSAGGHATLVPLDLTDYDAIDRLGAALNE
RWGRLDAVVGNAGILGNLMPVSHVTPKVWDQVMAINVTANWRLIRSFDPLLQRSDAGRAIFVSSGAAAKCRAYWGPYSVS
KAALEAMVRTYAAENESTGVRAMLLNPGPLRTGMRAAAMPGEDPATLKTPEELAPHFVRLASPAWNETGKLYDFPSDRVL
AFSAPQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=205, Percent_Identity=31.219512195122, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4504505, Length=242, Percent_Identity=28.5123966942149, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI5031737, Length=192, Percent_Identity=31.7708333333333, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=31.7708333333333, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=30.4, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=31.8918918918919, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI20149619, Length=208, Percent_Identity=29.8076923076923, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI7705925, Length=210, Percent_Identity=32.3809523809524, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI209862901, Length=206, Percent_Identity=30.0970873786408, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI19923983, Length=206, Percent_Identity=30.0970873786408, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4557649, Length=193, Percent_Identity=29.0155440414508, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI223718074, Length=213, Percent_Identity=29.5774647887324, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7657478, Length=218, Percent_Identity=27.5229357798165, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI66933014, Length=233, Percent_Identity=31.7596566523605, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI59889578, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787526, Length=234, Percent_Identity=37.6068376068376, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1787335, Length=191, Percent_Identity=29.3193717277487, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=30.4878048780488, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786812, Length=191, Percent_Identity=30.3664921465969, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789378, Length=230, Percent_Identity=30, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082100, Length=238, Percent_Identity=30.2521008403361, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=198, Percent_Identity=25.7575757575758, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786701, Length=199, Percent_Identity=30.6532663316583, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787905, Length=236, Percent_Identity=27.5423728813559, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787820, Length=204, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=205, Percent_Identity=33.1707317073171, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=245, Percent_Identity=30.2040816326531, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=211, Percent_Identity=33.6492890995261, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=201, Percent_Identity=30.8457711442786, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17568967, Length=241, Percent_Identity=26.1410788381743, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=207, Percent_Identity=30.9178743961353, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=208, Percent_Identity=34.1346153846154, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=227, Percent_Identity=25.9911894273128, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=28.2051282051282, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=209, Percent_Identity=31.1004784688995, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=251, Percent_Identity=32.2709163346614, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=202, Percent_Identity=33.1683168316832, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=223, Percent_Identity=27.8026905829596, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=198, Percent_Identity=29.7979797979798, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=200, Percent_Identity=30.5, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=210, Percent_Identity=28.0952380952381, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=248, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=210, Percent_Identity=31.9047619047619, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=203, Percent_Identity=33.4975369458128, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17555612, Length=205, Percent_Identity=30.7317073170732, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=194, Percent_Identity=30.9278350515464, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=223, Percent_Identity=30.4932735426009, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=194, Percent_Identity=30.9278350515464, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=200, Percent_Identity=30.5, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=204, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=193, Percent_Identity=32.6424870466321, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557780, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=210, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=254, Percent_Identity=26.3779527559055, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=236, Percent_Identity=27.9661016949153, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=34.010152284264, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322226, Length=209, Percent_Identity=30.622009569378, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322861, Length=244, Percent_Identity=27.0491803278689, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=193, Percent_Identity=27.979274611399, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21355319, Length=200, Percent_Identity=31.5, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=34.5549738219895, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357041, Length=191, Percent_Identity=33.5078534031414, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=35.4166666666667, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643142, Length=192, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859837, Length=239, Percent_Identity=29.7071129707113, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644339, Length=205, Percent_Identity=29.2682926829268, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356301, Length=215, Percent_Identity=29.7674418604651, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=228, Percent_Identity=25.4385964912281, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357673, Length=205, Percent_Identity=28.2926829268293, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24649181, Length=228, Percent_Identity=28.5087719298246, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554248, Length=253, Percent_Identity=26.4822134387352, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24640117, Length=253, Percent_Identity=26.4822134387352, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26113; Mature: 25982

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKILDGRVAVVTGASRGIGRAAALALAEAGAHVVAVARTQGGLEELDDAIRSAGGHAT
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEE
LVPLDLTDYDAIDRLGAALNERWGRLDAVVGNAGILGNLMPVSHVTPKVWDQVMAINVTA
EEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHCEEEEEEEC
NWRLIRSFDPLLQRSDAGRAIFVSSGAAAKCRAYWGPYSVSKAALEAMVRTYAAENESTG
CEEEEEHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCC
VRAMLLNPGPLRTGMRAAAMPGEDPATLKTPEELAPHFVRLASPAWNETGKLYDFPSDRV
EEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCE
LAFSAPQ
EEEECCC
>Mature Secondary Structure 
ADKILDGRVAVVTGASRGIGRAAALALAEAGAHVVAVARTQGGLEELDDAIRSAGGHAT
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEE
LVPLDLTDYDAIDRLGAALNERWGRLDAVVGNAGILGNLMPVSHVTPKVWDQVMAINVTA
EEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHCEEEEEEEC
NWRLIRSFDPLLQRSDAGRAIFVSSGAAAKCRAYWGPYSVSKAALEAMVRTYAAENESTG
CEEEEEHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCC
VRAMLLNPGPLRTGMRAAAMPGEDPATLKTPEELAPHFVRLASPAWNETGKLYDFPSDRV
EEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCE
LAFSAPQ
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]