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The map label for this gene is mazG [H]

Identifier: 218532169

GI number: 218532169

Start: 4517216

End: 4518046

Strand: Reverse

Name: mazG [H]

Synonym: Mchl_4281

Alternate gene names: 218532169

Gene position: 4518046-4517216 (Counterclockwise)

Preceding gene: 218532172

Following gene: 218532164

Centisome position: 78.2

GC content: 72.32

Gene sequence:

>831_bases
ATGGACGAGGCGCCGATCGACAGGCTGCTGACGCTGATGGCGCGGTTGCGCGATCCGGAACGGGGCTGCGCCTGGGACGT
GCAGCAGAGCTATGCCAGCATCGTCCCCTACACGATCGAGGAGGCCTACGAGGTCGCCGACGCGGTCGAGCGCGGCGACC
GGGCCGACCTGCGCGACGAACTCGGCGACCTCCTGCTCCAGGTCGTGTTCCAGGCGCGGATCGCCGAGGAGGAGGGCGCC
TTCCGCTTCGCTGACGTCGCCGAGGCGATCTGCGCCAAGCTGATCCGGCGTCACCCGCACGTCTTCGACGCGTCCGGTGA
CTTCCTGCCGCCCGAGCGGCGCCCGACCGACCCGGCCGCGATCAAGGCGGCCTGGGAGACGATCAAGGCGCAGGAGCGCG
CGGAGAAGGCGGCGGCTGGCAAAACGGAAGCGGCGGGACCGTTGGCCGGGGTCTCGCGCGCCCTCCCCGCCCTCGCCCGG
GCCGACCGGATCTCGAAGCGGGCGGCCGGCGTCGGCTTCGACTGGCCGGACGCGGCCCAGGTGCTGGCCAAGGTGCGCGA
GGAGACTGACGAGGTCGAGGAGAGCTTGGAGAAGGGCGAGCCGGAGGCGGTGTTCGAGGAGATCGGCGACCTGCTGTTCT
CGGTCGCCAACCTCGCCCGTCACGCGGGCGTCGATCCGGAGGAGGCCCTGCGGCGCGGCACCCTCAAGTTCGAGCGCCGC
TTCGCTGCCATGGCCGCCCGGCTCGCCGCCGAGGGCCACGCCCTGGAGGACACCGCCCTCCCCGCCATGGAAGCGGCCTG
GCAGGCGGTAAAGCGCGACGAGAAGACATGA

Upstream 100 bases:

>100_bases
ATCGAGAGCCCGCGAAGCGGCGCTGCGCGGCAGCGGCGGACGGTCTATGAGCGGTGGCTTGGCTGAGGCCGGGCTTCCGG
CGGGATGGGGCGAAAGAGCG

Downstream 100 bases:

>100_bases
GGTTCGGGGATCCCAAAGGGCCTCAGGCCCTTTGGCCGGTTGTCAGGGCAGTGCCCTGACGTCGGCGGAGCCGATGGGCA
GGGGCTCAGCCCTTCGTCCG

Product: MazG family protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MDEAPIDRLLTLMARLRDPERGCAWDVQQSYASIVPYTIEEAYEVADAVERGDRADLRDELGDLLLQVVFQARIAEEEGA
FRFADVAEAICAKLIRRHPHVFDASGDFLPPERRPTDPAAIKAAWETIKAQERAEKAAAGKTEAAGPLAGVSRALPALAR
ADRISKRAAGVGFDWPDAAQVLAKVREETDEVEESLEKGEPEAVFEEIGDLLFSVANLARHAGVDPEEALRRGTLKFERR
FAAMAARLAAEGHALEDTALPAMEAAWQAVKRDEKT

Sequences:

>Translated_276_residues
MDEAPIDRLLTLMARLRDPERGCAWDVQQSYASIVPYTIEEAYEVADAVERGDRADLRDELGDLLLQVVFQARIAEEEGA
FRFADVAEAICAKLIRRHPHVFDASGDFLPPERRPTDPAAIKAAWETIKAQERAEKAAAGKTEAAGPLAGVSRALPALAR
ADRISKRAAGVGFDWPDAAQVLAKVREETDEVEESLEKGEPEAVFEEIGDLLFSVANLARHAGVDPEEALRRGTLKFERR
FAAMAARLAAEGHALEDTALPAMEAAWQAVKRDEKT
>Mature_276_residues
MDEAPIDRLLTLMARLRDPERGCAWDVQQSYASIVPYTIEEAYEVADAVERGDRADLRDELGDLLLQVVFQARIAEEEGA
FRFADVAEAICAKLIRRHPHVFDASGDFLPPERRPTDPAAIKAAWETIKAQERAEKAAAGKTEAAGPLAGVSRALPALAR
ADRISKRAAGVGFDWPDAAQVLAKVREETDEVEESLEKGEPEAVFEEIGDLLFSVANLARHAGVDPEEALRRGTLKFERR
FAAMAARLAAEGHALEDTALPAMEAAWQAVKRDEKT

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=272, Percent_Identity=49.6323529411765, Blast_Score=241, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30269; Mature: 30269

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEAPIDRLLTLMARLRDPERGCAWDVQQSYASIVPYTIEEAYEVADAVERGDRADLRDE
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
LGDLLLQVVFQARIAEEEGAFRFADVAEAICAKLIRRHPHVFDASGDFLPPERRPTDPAA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHH
IKAAWETIKAQERAEKAAAGKTEAAGPLAGVSRALPALARADRISKRAAGVGFDWPDAAQ
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
VLAKVREETDEVEESLEKGEPEAVFEEIGDLLFSVANLARHAGVDPEEALRRGTLKFERR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FAAMAARLAAEGHALEDTALPAMEAAWQAVKRDEKT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDEAPIDRLLTLMARLRDPERGCAWDVQQSYASIVPYTIEEAYEVADAVERGDRADLRDE
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
LGDLLLQVVFQARIAEEEGAFRFADVAEAICAKLIRRHPHVFDASGDFLPPERRPTDPAA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHH
IKAAWETIKAQERAEKAAAGKTEAAGPLAGVSRALPALARADRISKRAAGVGFDWPDAAQ
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
VLAKVREETDEVEESLEKGEPEAVFEEIGDLLFSVANLARHAGVDPEEALRRGTLKFERR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FAAMAARLAAEGHALEDTALPAMEAAWQAVKRDEKT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]