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The map label for this gene is sucC [H]

Identifier: 218532112

GI number: 218532112

Start: 4431550

End: 4432704

Strand: Reverse

Name: sucC [H]

Synonym: Mchl_4207

Alternate gene names: 218532112

Gene position: 4432704-4431550 (Counterclockwise)

Preceding gene: 218532113

Following gene: 218532111

Centisome position: 76.72

GC content: 71.95

Gene sequence:

>1155_bases
ATGAACTTCCTGGAGCACGTCGCCAAGGCGCGGGTCCTCGCGCCCGCCGGCATCCCGGTCCCGCGCGCGGTGCTGTGCCG
GACGCCCGAGGAGGCCGCCGCCGCCTTCGGAGAACTCGGCCCCTGCATGGTCAAGGCCCAGGTGCCGACCGGCAAGCGCG
GCAAGGCCGGCGGCATCAAGCCGGCCAACGCGGCGGAAGAAGCCCGCGGCGTCGCCGAGCGCATCCTCGGCATGACGATC
GACTGCCACGCCGTCGGCGCGGTCCTGCTGGAGCAGCAGGCGACAATCGCCAGCGAGTTCTACGCCGCGGTGCTGATCGA
CACCGCGAGCCGGTGCCCGCTGGTCCTGTTCTCGACGGAGGGCGGGATGGACATCGAGGAAGTCGCCGCGACCCGGCCAG
ACGCTTTGCGCCGCCACGCCGTCGATCCCGAGGCCGGCTTCGACGCGGCCGCCGCCCGCGCGCTGCTGGCGGGCCTCGAC
CTCGGGGGCGCGGAGGGCGCGGTCGCCGACATCCTGGCCTCGCTCACCGAGACCAGCGGCCGGGTCGATGCGGAACTGAT
CGAGATCAACCCGCTCGCGGTGCTCGACGACGGCCGCGTCGTCGCCCTCGACTGCAAGCTGACGCTCGACGATTCCGCCG
CCTTCCGCCAGGGCGACCTCGCCGCGGAGGCGGCGGAGGAGCCGATGACCGAGCTGGAGCGGGAGGGCGCCGCCCAAGGC
CTCAAGTTCATCCAGCTCGACGGCGATGTCGGGGTGCTGGCCAACGGCGCCGGGCTGACGATGACGACCATGGACGTCAT
CAGCCATTGCGGCGGGCGGCCGGCGAACTTCCTCGAGATCGGCGGCGAAGCCTACACCAAGTCGGAAGCCGCGCTGAAGC
TCGTGCTGTCCAATCCCGGCGTCAAAAGCCTCGTCGTCAACTTCTGCGGCGCGTTTGCCCGCACCGACGTGATGGCGGAG
GGCGTCGTCACCGCCTGGAAGCGGCTCGACCCGGACATCCCGGTGTTCTTCTCGATCCACGGGACCGGGGAGGACGAGGC
CGTGCGCCTCGTGCGCGAGGGACTCGGCTGCGAGCCCTTCGACCTGATGGAGGACGCGGTCCAGGCCGCCGTGGACGCCG
CGCACTCGACTGCGAGCCGGGGAGTCGCCCGATGA

Upstream 100 bases:

>100_bases
ACATCACCCACCTCGTCACGCCGATCCCCGAGGACAAGCCGAGCGAGGAAGAGCTGTTCGGGCCGCACTGGAAACGGATC
GGCCACGAGGAGGCCGCGCG

Downstream 100 bases:

>100_bases
TCATCTACCGTCAGTCCGCCCGCGTCCTCGTCCAGGGCATCACGGGCAAGCAAGGCACCTTCTGGACGCAGAAGATGATG
GAGTGCGGCACGCAGGTGGT

Product: succinate--CoA ligase (ADP-forming)

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNFLEHVAKARVLAPAGIPVPRAVLCRTPEEAAAAFGELGPCMVKAQVPTGKRGKAGGIKPANAAEEARGVAERILGMTI
DCHAVGAVLLEQQATIASEFYAAVLIDTASRCPLVLFSTEGGMDIEEVAATRPDALRRHAVDPEAGFDAAAARALLAGLD
LGGAEGAVADILASLTETSGRVDAELIEINPLAVLDDGRVVALDCKLTLDDSAAFRQGDLAAEAAEEPMTELEREGAAQG
LKFIQLDGDVGVLANGAGLTMTTMDVISHCGGRPANFLEIGGEAYTKSEAALKLVLSNPGVKSLVVNFCGAFARTDVMAE
GVVTAWKRLDPDIPVFFSIHGTGEDEAVRLVREGLGCEPFDLMEDAVQAAVDAAHSTASRGVAR

Sequences:

>Translated_384_residues
MNFLEHVAKARVLAPAGIPVPRAVLCRTPEEAAAAFGELGPCMVKAQVPTGKRGKAGGIKPANAAEEARGVAERILGMTI
DCHAVGAVLLEQQATIASEFYAAVLIDTASRCPLVLFSTEGGMDIEEVAATRPDALRRHAVDPEAGFDAAAARALLAGLD
LGGAEGAVADILASLTETSGRVDAELIEINPLAVLDDGRVVALDCKLTLDDSAAFRQGDLAAEAAEEPMTELEREGAAQG
LKFIQLDGDVGVLANGAGLTMTTMDVISHCGGRPANFLEIGGEAYTKSEAALKLVLSNPGVKSLVVNFCGAFARTDVMAE
GVVTAWKRLDPDIPVFFSIHGTGEDEAVRLVREGLGCEPFDLMEDAVQAAVDAAHSTASRGVAR
>Mature_384_residues
MNFLEHVAKARVLAPAGIPVPRAVLCRTPEEAAAAFGELGPCMVKAQVPTGKRGKAGGIKPANAAEEARGVAERILGMTI
DCHAVGAVLLEQQATIASEFYAAVLIDTASRCPLVLFSTEGGMDIEEVAATRPDALRRHAVDPEAGFDAAAARALLAGLD
LGGAEGAVADILASLTETSGRVDAELIEINPLAVLDDGRVVALDCKLTLDDSAAFRQGDLAAEAAEEPMTELEREGAAQG
LKFIQLDGDVGVLANGAGLTMTTMDVISHCGGRPANFLEIGGEAYTKSEAALKLVLSNPGVKSLVVNFCGAFARTDVMAE
GVVTAWKRLDPDIPVFFSIHGTGEDEAVRLVREGLGCEPFDLMEDAVQAAVDAAHSTASRGVAR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=381, Percent_Identity=33.5958005249344, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI157779135, Length=371, Percent_Identity=30.188679245283, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI294862256, Length=360, Percent_Identity=30.5555555555556, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1786948, Length=336, Percent_Identity=37.797619047619, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17567829, Length=385, Percent_Identity=31.9480519480519, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17539378, Length=392, Percent_Identity=32.1428571428571, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321683, Length=392, Percent_Identity=30.6122448979592, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI161078106, Length=397, Percent_Identity=35.7682619647355, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24645208, Length=397, Percent_Identity=35.7682619647355, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI281361397, Length=400, Percent_Identity=36, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI281361395, Length=400, Percent_Identity=36, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI21356231, Length=396, Percent_Identity=30.5555555555556, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 39826; Mature: 39826

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLEHVAKARVLAPAGIPVPRAVLCRTPEEAAAAFGELGPCMVKAQVPTGKRGKAGGIK
CCHHHHHHHHHEECCCCCCCCHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
PANAAEEARGVAERILGMTIDCHAVGAVLLEQQATIASEFYAAVLIDTASRCPLVLFSTE
CCCHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECC
GGMDIEEVAATRPDALRRHAVDPEAGFDAAAARALLAGLDLGGAEGAVADILASLTETSG
CCCCHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
RVDAELIEINPLAVLDDGRVVALDCKLTLDDSAAFRQGDLAAEAAEEPMTELEREGAAQG
CCCEEEEEECCEEEECCCCEEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHCC
LKFIQLDGDVGVLANGAGLTMTTMDVISHCGGRPANFLEIGGEAYTKSEAALKLVLSNPG
CEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCHHEEECCCHHCCCCCEEEEEECCCC
VKSLVVNFCGAFARTDVMAEGVVTAWKRLDPDIPVFFSIHGTGEDEAVRLVREGLGCEPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHH
DLMEDAVQAAVDAAHSTASRGVAR
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNFLEHVAKARVLAPAGIPVPRAVLCRTPEEAAAAFGELGPCMVKAQVPTGKRGKAGGIK
CCHHHHHHHHHEECCCCCCCCHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
PANAAEEARGVAERILGMTIDCHAVGAVLLEQQATIASEFYAAVLIDTASRCPLVLFSTE
CCCHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECC
GGMDIEEVAATRPDALRRHAVDPEAGFDAAAARALLAGLDLGGAEGAVADILASLTETSG
CCCCHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
RVDAELIEINPLAVLDDGRVVALDCKLTLDDSAAFRQGDLAAEAAEEPMTELEREGAAQG
CCCEEEEEECCEEEECCCCEEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHCC
LKFIQLDGDVGVLANGAGLTMTTMDVISHCGGRPANFLEIGGEAYTKSEAALKLVLSNPG
CEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCHHEEECCCHHCCCCCEEEEEECCCC
VKSLVVNFCGAFARTDVMAEGVVTAWKRLDPDIPVFFSIHGTGEDEAVRLVREGLGCEPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHH
DLMEDAVQAAVDAAHSTASRGVAR
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA