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The map label for this gene is ctaB

Identifier: 218531517

GI number: 218531517

Start: 3773129

End: 3774082

Strand: Reverse

Name: ctaB

Synonym: Mchl_3585

Alternate gene names: 218531517

Gene position: 3774082-3773129 (Counterclockwise)

Preceding gene: 218531518

Following gene: 218531516

Centisome position: 65.32

GC content: 69.39

Gene sequence:

>954_bases
ATGACGAGCCTGTCGAACAGCCTGAGTGCCGACACCGGCACCACGTCGTTCTCCCCCGCCGCGGGGGGCGAGGTTTCCGA
CTTCTTCGCCCTGCTGAAGCCGCGGGTGATGGTGCTCGTCATCTTCACCGCGCTCGTCGGCATGGTGGTCTCGGACGCCA
CCGTGAACCCGGTGATCGCGGCGATCTCGCTCCTGATGATCGCCGTCGGCGCGGGCGCCTCGGGCTGCCTCAACATGTGG
TGGGACGCCGATATCGACGCGCTGATGACCCGCACCGCCAAGCGTCCGATCCCGGACGGCCGCATCCGCCCCGACGAGGC
GCTGGCCTTCGGCATCGTCCTGTCGGTCGGCTCGGTGCTGATCCTCGGGTTGGCCTCGAATTGGCTCGCGGCCGGGCTGC
TCGCCTTCACCATCGTGTTCTACGCCGTGATCTACTCGATGTGGCTGAAGCGGGCGACCGCGCAGAACATCGTCATCGGC
GGCGCGGCCGGCGCCCTCCCCCCGGTGGTGGGCCAGGCCGCCGTGACCGGTCATGTCGGCATCGAGTCGCTGGTTCTGTT
CGCGATCATCTTCATCTGGACGCCGCCGCATTTCTGGGCGCTGGCGCTCGTGAAGAGCGGCGAGTACGCCCGCGCCGGCA
TCCCGATGATGCCGAACGTCGCCGGCCCGGATTCCACCCGCCGCCAGATCATCTGGTACTCGCTGGTCCTCGCGCCGCTG
GCCCTCCTGCCGGTCTGGCTCGGCTTCGGCGGCTGGCTCTACGCCGTCGTCGGCGTGCTCGGCGGGCTCGGCATGCTGGC
GGGCGCGGTGCAGGTCTACCGGCTGCGTGAGGGCGAGCCCGAGCGCAAGGCGGCGATGGGCCTGTTCGCCTTCTCGATCC
TCTACCTGTTCCTGCTCTTCTCGGCGCTGCTCGCCGAGCAGGGACTCGGATTGTTCCGCGCGGTCGCAGCGTGA

Upstream 100 bases:

>100_bases
CTCACCGCTAAGGCGAGGCCTCCCGCAAAGGGCGGCGCCCCGAACGGCGCGATCCGAAGACCTACGAAAACATCAGAACA
AGCGTCAGAGCACGGTTTCC

Downstream 100 bases:

>100_bases
GGCCCGCCATGTCCGATCTTCCCGAGGGGATCCGTCCGCTGACGCCGGCGGAGGCCAGGACCCGCCGCAAGCGCTCGGTC
GCCATTGCCCTGACGCTCGG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTSLSNSLSADTGTTSFSPAAGGEVSDFFALLKPRVMVLVIFTALVGMVVSDATVNPVIAAISLLMIAVGAGASGCLNMW
WDADIDALMTRTAKRPIPDGRIRPDEALAFGIVLSVGSVLILGLASNWLAAGLLAFTIVFYAVIYSMWLKRATAQNIVIG
GAAGALPPVVGQAAVTGHVGIESLVLFAIIFIWTPPHFWALALVKSGEYARAGIPMMPNVAGPDSTRRQIIWYSLVLAPL
ALLPVWLGFGGWLYAVVGVLGGLGMLAGAVQVYRLREGEPERKAAMGLFAFSILYLFLLFSALLAEQGLGLFRAVAA

Sequences:

>Translated_317_residues
MTSLSNSLSADTGTTSFSPAAGGEVSDFFALLKPRVMVLVIFTALVGMVVSDATVNPVIAAISLLMIAVGAGASGCLNMW
WDADIDALMTRTAKRPIPDGRIRPDEALAFGIVLSVGSVLILGLASNWLAAGLLAFTIVFYAVIYSMWLKRATAQNIVIG
GAAGALPPVVGQAAVTGHVGIESLVLFAIIFIWTPPHFWALALVKSGEYARAGIPMMPNVAGPDSTRRQIIWYSLVLAPL
ALLPVWLGFGGWLYAVVGVLGGLGMLAGAVQVYRLREGEPERKAAMGLFAFSILYLFLLFSALLAEQGLGLFRAVAA
>Mature_316_residues
TSLSNSLSADTGTTSFSPAAGGEVSDFFALLKPRVMVLVIFTALVGMVVSDATVNPVIAAISLLMIAVGAGASGCLNMWW
DADIDALMTRTAKRPIPDGRIRPDEALAFGIVLSVGSVLILGLASNWLAAGLLAFTIVFYAVIYSMWLKRATAQNIVIGG
AAGALPPVVGQAAVTGHVGIESLVLFAIIFIWTPPHFWALALVKSGEYARAGIPMMPNVAGPDSTRRQIIWYSLVLAPLA
LLPVWLGFGGWLYAVVGVLGGLGMLAGAVQVYRLREGEPERKAAMGLFAFSILYLFLLFSALLAEQGLGLFRAVAA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=170, Percent_Identity=35.2941176470588, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786631, Length=223, Percent_Identity=33.6322869955157, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=197, Percent_Identity=32.994923857868, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=236, Percent_Identity=29.6610169491525, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921064, Length=276, Percent_Identity=27.8985507246377, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_METC4 (B7KVJ7)

Other databases:

- EMBL:   CP001298
- RefSeq:   YP_002422333.1
- GeneID:   7113718
- GenomeReviews:   CP001298_GR
- KEGG:   mch:Mchl_3585
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33339; Mature: 33208

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x261567d8)-; HASH(0x256be818)-; HASH(0x26a07e04)-; HASH(0x269ee04c)-; HASH(0x269ea604)-; HASH(0x269fa6e8)-; HASH(0x269fa760)-; HASH(0x264925a0)-; HASH(0x265b0850)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLSNSLSADTGTTSFSPAAGGEVSDFFALLKPRVMVLVIFTALVGMVVSDATVNPVIA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AISLLMIAVGAGASGCLNMWWDADIDALMTRTAKRPIPDGRIRPDEALAFGIVLSVGSVL
HHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
ILGLASNWLAAGLLAFTIVFYAVIYSMWLKRATAQNIVIGGAAGALPPVVGQAAVTGHVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHCCHHHHHHHH
IESLVLFAIIFIWTPPHFWALALVKSGEYARAGIPMMPNVAGPDSTRRQIIWYSLVLAPL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ALLPVWLGFGGWLYAVVGVLGGLGMLAGAVQVYRLREGEPERKAAMGLFAFSILYLFLLF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SALLAEQGLGLFRAVAA
HHHHHHCCCHHHHHHCH
>Mature Secondary Structure 
TSLSNSLSADTGTTSFSPAAGGEVSDFFALLKPRVMVLVIFTALVGMVVSDATVNPVIA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH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HHHHHHCCCHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA