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The map label for this gene is atoC [H]

Identifier: 218530930

GI number: 218530930

Start: 3144131

End: 3145621

Strand: Reverse

Name: atoC [H]

Synonym: Mchl_2980

Alternate gene names: 218530930

Gene position: 3145621-3144131 (Counterclockwise)

Preceding gene: 218530946

Following gene: 218530929

Centisome position: 54.44

GC content: 67.67

Gene sequence:

>1491_bases
ATGTCGACCACCGTTCTCATCATCGACGACGATCCCGTGCAGCGTCGCCTCGCCGAGGCAATGGTGCGCCGCCTCGGTTT
CCAGGCACAGATTGCGGAGAACGGCCATGACGGGTTGAACCTCCTGCGCAGCGGCGAGAGCGTCGATGTCGTGCTGCTCG
ATCTCGTCATGCCCGGCGGCATGGACGGGCTGAGCGTGCTGGCCGAGATGCGCAAGAGCGGCATCGATACCCCCGTCATC
GTGCAGACGTCGAACGGCTCCATCGACGCGGTGGTGAACGCCATGCGGGCGGGCGCCGTCGATTTCGTGGTCAAGCCGGC
CGGTGCCGAGCGGCTCCAGGTCTCGATCAAGAACGCCCTGCGGGTCGATCAGCTCGAGGAGGAGGTGCGCCGGATGCGCC
GTCGCGCCTCGGGCGCGCTGGGCTTCAAGGATCTCGCCTCGAAGAGCCCGGACATGGAGCGGGTGATTCGGCTGGCCGAG
CGGTCGGCGAAATCGAACATTCCCGTCCTGATCGAGGGCGAATCAGGCGTTGGCAAGGAAGTGCTGGCGCGCGCGATCCA
AGGCTCGGGCGACCGGCGCGGCAAGGCCTTCGTCACCGTCAATTGCGGGGCGATCCCCGAGAACCTCGTCGAATCGACCC
TGTTCGGTCACGAGAAGGGCGCCTTCACCGGCGCCACGGAGAAGCATGTCGGTAAGTTCGTCGAGGCCTCAGGGGGCACC
CTGTTCCTCGACGAGATCGGCGAGCTGCCCCTCGACGCACAGGTGAAGCTGCTGCGGGCGCTGCAGGAGGGCGAGGTCGA
TCCCGTCGGGGGCAAGCGCGCCGTGCGCGTCGATATCCGCCTGATCTCGGCCACCAACCGCTCGCTGCTCGACCTCGTGA
AACAGGGCAAGTTCCGCGAGGATCTCTATTACCGCCTCAACGTCTTCCCCATGACGCTGCCGCCGCTGCGGGCGCGGCGC
GAGGACATTCCGGATCTCGTGCGCTCGTTCTGCGCGCGGTTCGCGGCGGAAGAGGGCAAACGCCTGCGCGGCATCACGGC
CGAGGCGATGGCGTTGCTCTCGCGCTATCCCTGGCCCGGCAACGTGCGCCAGCTCGAGAATGCGCTGTTCCGTGCGGTCG
TGCTCGCCGACGGCGACGAACTGACGGTGGCGGAGTTTCCGCAGATCGCGGCGCAGGTCGAGGGCTTCGACGTCCGCATC
CCGCCGCTGCCGACACAGGCCGCCCTGCCCGCGGGCGGCCTCGAGCCGGTGCGGGAGATCGTCCGCGTCGAGGTGCGCGA
TCCCCACGCCATGTCGCTCGTCGTCGAGGACACCGGCGACATGAAGACGATGGAAGCCGTCGAAGCGGAGGTGATCCGCT
TCGCCCTGCAATTTTACCGCGGCCGAATGTCCGAAGTCTCCCGCCGCCTCGGAATCGGCCGATCGACCCTCTACCGCAAA
CTCAAGGAGCTCGGCCTCGACGACGAGGAGCGTTCCGAGGACGCCGCCTGA

Upstream 100 bases:

>100_bases
TGTGCCTCGAAACGAAACAGCCGCCGCCATGCGCCGCCGGTCTCCGCTGGGAGGCCGGGTCGGCCCGCGGCCGGTTTGAG
CGGAAAGCGAGGCGCCCCGC

Downstream 100 bases:

>100_bases
GGCCGGACAGTCGTTCAGAGCATCGTTCCGAAAGGCAATCGCCGGCTTTCGGGACAATGCGAAAACAAGAGGCAAACGCA
TCGTCCTCGATCCGATATCA

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSTTVLIIDDDPVQRRLAEAMVRRLGFQAQIAENGHDGLNLLRSGESVDVVLLDLVMPGGMDGLSVLAEMRKSGIDTPVI
VQTSNGSIDAVVNAMRAGAVDFVVKPAGAERLQVSIKNALRVDQLEEEVRRMRRRASGALGFKDLASKSPDMERVIRLAE
RSAKSNIPVLIEGESGVGKEVLARAIQGSGDRRGKAFVTVNCGAIPENLVESTLFGHEKGAFTGATEKHVGKFVEASGGT
LFLDEIGELPLDAQVKLLRALQEGEVDPVGGKRAVRVDIRLISATNRSLLDLVKQGKFREDLYYRLNVFPMTLPPLRARR
EDIPDLVRSFCARFAAEEGKRLRGITAEAMALLSRYPWPGNVRQLENALFRAVVLADGDELTVAEFPQIAAQVEGFDVRI
PPLPTQAALPAGGLEPVREIVRVEVRDPHAMSLVVEDTGDMKTMEAVEAEVIRFALQFYRGRMSEVSRRLGIGRSTLYRK
LKELGLDDEERSEDAA

Sequences:

>Translated_496_residues
MSTTVLIIDDDPVQRRLAEAMVRRLGFQAQIAENGHDGLNLLRSGESVDVVLLDLVMPGGMDGLSVLAEMRKSGIDTPVI
VQTSNGSIDAVVNAMRAGAVDFVVKPAGAERLQVSIKNALRVDQLEEEVRRMRRRASGALGFKDLASKSPDMERVIRLAE
RSAKSNIPVLIEGESGVGKEVLARAIQGSGDRRGKAFVTVNCGAIPENLVESTLFGHEKGAFTGATEKHVGKFVEASGGT
LFLDEIGELPLDAQVKLLRALQEGEVDPVGGKRAVRVDIRLISATNRSLLDLVKQGKFREDLYYRLNVFPMTLPPLRARR
EDIPDLVRSFCARFAAEEGKRLRGITAEAMALLSRYPWPGNVRQLENALFRAVVLADGDELTVAEFPQIAAQVEGFDVRI
PPLPTQAALPAGGLEPVREIVRVEVRDPHAMSLVVEDTGDMKTMEAVEAEVIRFALQFYRGRMSEVSRRLGIGRSTLYRK
LKELGLDDEERSEDAA
>Mature_495_residues
STTVLIIDDDPVQRRLAEAMVRRLGFQAQIAENGHDGLNLLRSGESVDVVLLDLVMPGGMDGLSVLAEMRKSGIDTPVIV
QTSNGSIDAVVNAMRAGAVDFVVKPAGAERLQVSIKNALRVDQLEEEVRRMRRRASGALGFKDLASKSPDMERVIRLAER
SAKSNIPVLIEGESGVGKEVLARAIQGSGDRRGKAFVTVNCGAIPENLVESTLFGHEKGAFTGATEKHVGKFVEASGGTL
FLDEIGELPLDAQVKLLRALQEGEVDPVGGKRAVRVDIRLISATNRSLLDLVKQGKFREDLYYRLNVFPMTLPPLRARRE
DIPDLVRSFCARFAAEEGKRLRGITAEAMALLSRYPWPGNVRQLENALFRAVVLADGDELTVAEFPQIAAQVEGFDVRIP
PLPTQAALPAGGLEPVREIVRVEVRDPHAMSLVVEDTGDMKTMEAVEAEVIRFALQFYRGRMSEVSRRLGIGRSTLYRKL
KELGLDDEERSEDAA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=483, Percent_Identity=40.1656314699793, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI1790437, Length=478, Percent_Identity=39.9581589958159, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI1790299, Length=483, Percent_Identity=39.3374741200828, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1788905, Length=490, Percent_Identity=37.1428571428571, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082117, Length=282, Percent_Identity=47.1631205673759, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1789087, Length=391, Percent_Identity=39.386189258312, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI1789233, Length=336, Percent_Identity=41.9642857142857, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87082152, Length=344, Percent_Identity=41.5697674418605, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1787583, Length=356, Percent_Identity=37.0786516853933, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786524, Length=353, Percent_Identity=38.5269121813031, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI87081872, Length=207, Percent_Identity=44.9275362318841, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789828, Length=248, Percent_Identity=41.9354838709677, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87081858, Length=369, Percent_Identity=30.0813008130081, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54297; Mature: 54166

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTVLIIDDDPVQRRLAEAMVRRLGFQAQIAENGHDGLNLLRSGESVDVVLLDLVMPGG
CCEEEEEECCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCEEEEEEECCCCC
MDGLSVLAEMRKSGIDTPVIVQTSNGSIDAVVNAMRAGAVDFVVKPAGAERLQVSIKNAL
CHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
RVDQLEEEVRRMRRRASGALGFKDLASKSPDMERVIRLAERSAKSNIPVLIEGESGVGKE
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHH
VLARAIQGSGDRRGKAFVTVNCGAIPENLVESTLFGHEKGAFTGATEKHVGKFVEASGGT
HHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCE
LFLDEIGELPLDAQVKLLRALQEGEVDPVGGKRAVRVDIRLISATNRSLLDLVKQGKFRE
EEHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCHH
DLYYRLNVFPMTLPPLRARREDIPDLVRSFCARFAAEEGKRLRGITAEAMALLSRYPWPG
HHEEEEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCCCCC
NVRQLENALFRAVVLADGDELTVAEFPQIAAQVEGFDVRIPPLPTQAALPAGGLEPVREI
CHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHH
VRVEVRDPHAMSLVVEDTGDMKTMEAVEAEVIRFALQFYRGRMSEVSRRLGIGRSTLYRK
HEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LKELGLDDEERSEDAA
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
STTVLIIDDDPVQRRLAEAMVRRLGFQAQIAENGHDGLNLLRSGESVDVVLLDLVMPGG
CEEEEEECCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCEEEEEEECCCCC
MDGLSVLAEMRKSGIDTPVIVQTSNGSIDAVVNAMRAGAVDFVVKPAGAERLQVSIKNAL
CHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
RVDQLEEEVRRMRRRASGALGFKDLASKSPDMERVIRLAERSAKSNIPVLIEGESGVGKE
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHH
VLARAIQGSGDRRGKAFVTVNCGAIPENLVESTLFGHEKGAFTGATEKHVGKFVEASGGT
HHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCE
LFLDEIGELPLDAQVKLLRALQEGEVDPVGGKRAVRVDIRLISATNRSLLDLVKQGKFRE
EEHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCHH
DLYYRLNVFPMTLPPLRARREDIPDLVRSFCARFAAEEGKRLRGITAEAMALLSRYPWPG
HHEEEEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCCCCC
NVRQLENALFRAVVLADGDELTVAEFPQIAAQVEGFDVRIPPLPTQAALPAGGLEPVREI
CHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHH
VRVEVRDPHAMSLVVEDTGDMKTMEAVEAEVIRFALQFYRGRMSEVSRRLGIGRSTLYRK
HEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LKELGLDDEERSEDAA
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]