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The map label for this gene is acoB [H]

Identifier: 218236134

GI number: 218236134

Start: 2683403

End: 2684437

Strand: Reverse

Name: acoB [H]

Synonym: BCB4264_A2784

Alternate gene names: 218236134

Gene position: 2684437-2683403 (Counterclockwise)

Preceding gene: 218231470

Following gene: 218230914

Centisome position: 49.54

GC content: 40.0

Gene sequence:

>1035_bases
ATGACTAGAACAGTAAGTATGTCAACTGCAATTAATGAAGCGATGAAAATCTCAATGCGTCGTGATGAAAATGTAATTTT
AATAGGTGAAGATGTTGCAGGCGGTGCACAAGTTGATCATCTGCAAGATGATGAAGCATGGGGCGGTGTTCTTGGTGTTA
CGAAAGGACTTGTACAAGAGTTTGGCCGAAATCGTATATTGGATACACCAATTTCTGAAGCGGGTTATATGGGAGCCGCG
ATGGCAGCTGCTGCAACTGGGTTACGTCCGATAGCTGAGTTAATGTTTAATGATTTTATCGGTAGTTGTCTTGACCAAGT
ATTAAACCAAGGTGCGAAATTCCGTTATATGTTTGGAGGTAAAGCAAAAGTACCTGTTACAGTACGTACGATGCATGGCG
CTGGTTTTAGTGCAGCAGCTCAGCATTCACAAAGTTTGTACGCATTATTTACGAGCATACCAGGTATTAAAGTTGTTGTT
CCTTCCACGCCGTATGATGCAAAAGGCTTATTATTAGCAGCAATTGAAGATGATGATCCAGTAATCTTCTTTGAGGATAA
AACACTTTACAATATGAAAGGTGAAGTGCCAGAAGGATACTATACAATTCCATTAGGAAAAGCCGATATGAAACGGGAAG
GTTCTGATGTAACAATCGTTGCAATCGGAAAGCAAGTTCATACGGCGCTTGCAGCTGCAAAGCAATTATCGAAAAAGGGG
CTTGAAGTAGAAGTAATTGATCCACGATCTTTATCACCGCTTGATGAGGATACGATTTTATCATCTGTTGAAAAAACAAA
TCGTCTTATCGTCATTGATGAAGCAAACCCAAGATGTAGTATGGCAACAGATATTGCGGCAATTGTAGCGGATAAAGGTT
TTGATTTGTTAGATGCACCTATTAAACGAATTACAGCACCACACACACCTGTTCCGTTCTCACCGCCACTTGAAAAGTTG
TATTTGCCAACGCCAGAAAAAGTAATTGAAACTGTATCAGAAATGATTGGAGACCAATCTTTATTACATGTGTAA

Upstream 100 bases:

>100_bases
AAAGATCCATTGAATTTAGTGAAAATAGTCCATACCCAGACGATGAAGAATTATTAAAAGATGTATACGTTTTTTACAAA
TAAGAGGAGGTTGAAAAATT

Downstream 100 bases:

>100_bases
TAAAACGATGAGAAGGGAGAGAGAAACATGGCTGTAGAAGTTGTAATGCCGAAGTTAGGTATGGCGATGAAAGAAGGTAT
TATTACGAGCTGGAATATTA

Product: TPP-dependent acetoin dehydrogenase E1 beta-subunit

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQEFGRNRILDTPISEAGYMGAA
MAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGGKAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVV
PSTPYDAKGLLLAAIEDDDPVIFFEDKTLYNMKGEVPEGYYTIPLGKADMKREGSDVTIVAIGKQVHTALAAAKQLSKKG
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSMATDIAAIVADKGFDLLDAPIKRITAPHTPVPFSPPLEKL
YLPTPEKVIETVSEMIGDQSLLHV

Sequences:

>Translated_344_residues
MTRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQEFGRNRILDTPISEAGYMGAA
MAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGGKAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVV
PSTPYDAKGLLLAAIEDDDPVIFFEDKTLYNMKGEVPEGYYTIPLGKADMKREGSDVTIVAIGKQVHTALAAAKQLSKKG
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSMATDIAAIVADKGFDLLDAPIKRITAPHTPVPFSPPLEKL
YLPTPEKVIETVSEMIGDQSLLHV
>Mature_343_residues
TRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQEFGRNRILDTPISEAGYMGAAM
AAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGGKAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVVP
STPYDAKGLLLAAIEDDDPVIFFEDKTLYNMKGEVPEGYYTIPLGKADMKREGSDVTIVAIGKQVHTALAAAKQLSKKGL
EVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSMATDIAAIVADKGFDLLDAPIKRITAPHTPVPFSPPLEKLY
LPTPEKVIETVSEMIGDQSLLHV

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=337, Percent_Identity=39.4658753709199, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4557353, Length=338, Percent_Identity=39.3491124260355, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI34101272, Length=338, Percent_Identity=39.3491124260355, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI291084858, Length=337, Percent_Identity=37.6854599406528, Blast_Score=221, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17538422, Length=338, Percent_Identity=41.1242603550296, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17506935, Length=337, Percent_Identity=43.026706231454, Blast_Score=237, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6319698, Length=341, Percent_Identity=39.5894428152493, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21358145, Length=340, Percent_Identity=37.9411764705882, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24650940, Length=340, Percent_Identity=37.9411764705882, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI160714832, Length=338, Percent_Identity=38.1656804733728, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI160714828, Length=338, Percent_Identity=38.1656804733728, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24650943, Length=104, Percent_Identity=34.6153846153846, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650945, Length=104, Percent_Identity=34.6153846153846, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 37031; Mature: 36900

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQE
CCEEEEHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGRNRILDTPISEAGYMGAAMAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGG
HCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVVPSTPYDAKGLLLAAIEDDDP
CEECCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCC
VIFFEDKTLYNMKGEVPEGYYTIPLGKADMKREGSDVTIVAIGKQVHTALAAAKQLSKKG
EEEEECCEEEECCCCCCCCEEEEECCCHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHCC
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSMATDIAAIVADKGFDLLDAP
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHH
IKRITAPHTPVPFSPPLEKLYLPTPEKVIETVSEMIGDQSLLHV
HHHHCCCCCCCCCCCCHHHEECCCHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
TRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQE
CEEEEHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGRNRILDTPISEAGYMGAAMAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGG
HCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVVPSTPYDAKGLLLAAIEDDDP
CEECCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCC
VIFFEDKTLYNMKGEVPEGYYTIPLGKADMKREGSDVTIVAIGKQVHTALAAAKQLSKKG
EEEEECCEEEECCCCCCCCEEEEECCCHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHCC
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSMATDIAAIVADKGFDLLDAP
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHH
IKRITAPHTPVPFSPPLEKLYLPTPEKVIETVSEMIGDQSLLHV
HHHHCCCCCCCCCCCCHHHEECCCHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10368162; 8969503; 9384377 [H]