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The map label for this gene is trpE [H]

Identifier: 218235640

GI number: 218235640

Start: 1252312

End: 1253730

Strand: Direct

Name: trpE [H]

Synonym: BCB4264_A1291

Alternate gene names: 218235640

Gene position: 1252312-1253730 (Clockwise)

Preceding gene: 218235221

Following gene: 218234059

Centisome position: 23.11

GC content: 38.83

Gene sequence:

>1419_bases
ATGATGACGAAAGAAGAATTTATAAAACAAAAAAGAGAGAGAACGACATTTTTAGTAATCACTGAAGAAGAAGGAGATAG
CATTACGCCAATTTCTTTATATAGACGTATGAAAGGAAAGAAGAAATTCTTATTAGAAAGTTCACAGCTTCATCAAGATA
AAGGGCGTTATTCTTACTTAGGATGTAATCCTTATGGAGAAGTGAAAAGCGTTGGTACAGAAGTGGAACGAACGATTTAC
GGCCGGTCAGAAAAGTTGCAAAGTAACGTACTTCAAGTGTTAGAAGAAGTGATCGCGTCAGCTCAAGTAGAGAGTCCATT
TCCATTTTGCGGGGGAGCAGTTGGTTATATTGGATATGACGTCATTCGGCAGTATGAAAACATTGGAGCGGATTTACACG
ACCCATTAAATATTCCGGAAGTACACCTTTTACTATATCGTGAGTTTATCGTTTACGATCATTTACGCCAAAAGTTGTCG
TTTGTATATGTATGCAGGCAAGATGATTCAGCAGATTATGAAGAAGTATACGAAAGGCTACGAGTATACAAAGAGGAAGT
GATACAAGGAGAAGAAGCTGAAGTAAATGCAATACAATCCCCATTATCATTCACTTCTTCTATAACGGAAAAAGAGTTTT
GTGAGATGGTAGAAATGGCGAAAGAATATATAAGAGCGGGAGACATATTCCAAGTTGTACTGTCACAGCGTTTACAAAGT
GAATGTATTGGTGATCCATTCGCGTTATATCGAAAACTTCGAATTGCAAATCCATCACCATATATGTTCTATATCGATTT
TCAAGATTATGTTGTACTCGGTTCCTCGCCGGAAAGTTTACTATCAGTAAGGGAGGATAAAGTGATGACGAATCCAATTG
CTGGTACAAGGCCGAGGGGGAAAACGAAGAGGGAAGATGAGGAAATCGCAAAAGAACTGTTAGGCAATGAGAAAGAGCGA
GCAGAGCATATGATGCTTGTAGATCTTGGGCGAAACGATATTGGTAGAGTGAGTGAAATCGGCTCGGTTACGATAGATAA
ATATATGAAAGTAGAAAAATATTCTCACGTTATGCACATTGTATCCGAAGTTTACGGAACATTGCAAAAACAAATGGGCG
GATTTGATGCGTTAGCGTATTGCTTACCAGCAGGGACGGTTTCTGGAGCTCCGAAAATTAGAGCGATGGAAATTATAAAT
GAACTAGAAAATGAAAAAAGAAATGTATACGCTGGTGCAGTTGGATACGTTAGTTTTTCAGGAAATCTTGATATGGCGCT
CGCCATTCGAACGATGGTCGTAAAGGATGAAAAAGCATATGTTCAGGCAGGAGCAGGAGTCGTTTACGATTCAGATCCAG
TAGCTGAATATGAAGAAACATTAAATAAAGCGAGAGCGCTTTTGGAGGTAATGAAATGA

Upstream 100 bases:

>100_bases
TTTGCATCCAACACGAGGTGGTACCGCGGTATATTTATCGTCCTCTACATATTTTCGATATGTAGAGGACTTTTTTATTT
TTCAGGGCGAGGTGAAGGAC

Downstream 100 bases:

>100_bases
TTGTACTTATCGATAATTACGATTCGTTCACATATAACTTGTATCAACTGTTAGGCGAACATGAAGAAGAAATTGTAGTT
GTAAGAAATGATGAAATAAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MMTKEEFIKQKRERTTFLVITEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYLGCNPYGEVKSVGTEVERTIY
GRSEKLQSNVLQVLEEVIASAQVESPFPFCGGAVGYIGYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQKLS
FVYVCRQDDSADYEEVYERLRVYKEEVIQGEEAEVNAIQSPLSFTSSITEKEFCEMVEMAKEYIRAGDIFQVVLSQRLQS
ECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRGKTKREDEEIAKELLGNEKER
AEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHIVSEVYGTLQKQMGGFDALAYCLPAGTVSGAPKIRAMEIIN
ELENEKRNVYAGAVGYVSFSGNLDMALAIRTMVVKDEKAYVQAGAGVVYDSDPVAEYEETLNKARALLEVMK

Sequences:

>Translated_472_residues
MMTKEEFIKQKRERTTFLVITEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYLGCNPYGEVKSVGTEVERTIY
GRSEKLQSNVLQVLEEVIASAQVESPFPFCGGAVGYIGYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQKLS
FVYVCRQDDSADYEEVYERLRVYKEEVIQGEEAEVNAIQSPLSFTSSITEKEFCEMVEMAKEYIRAGDIFQVVLSQRLQS
ECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRGKTKREDEEIAKELLGNEKER
AEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHIVSEVYGTLQKQMGGFDALAYCLPAGTVSGAPKIRAMEIIN
ELENEKRNVYAGAVGYVSFSGNLDMALAIRTMVVKDEKAYVQAGAGVVYDSDPVAEYEETLNKARALLEVMK
>Mature_472_residues
MMTKEEFIKQKRERTTFLVITEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYLGCNPYGEVKSVGTEVERTIY
GRSEKLQSNVLQVLEEVIASAQVESPFPFCGGAVGYIGYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQKLS
FVYVCRQDDSADYEEVYERLRVYKEEVIQGEEAEVNAIQSPLSFTSSITEKEFCEMVEMAKEYIRAGDIFQVVLSQRLQS
ECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRGKTKREDEEIAKELLGNEKER
AEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHIVSEVYGTLQKQMGGFDALAYCLPAGTVSGAPKIRAMEIIN
ELENEKRNVYAGAVGYVSFSGNLDMALAIRTMVVKDEKAYVQAGAGVVYDSDPVAEYEETLNKARALLEVMK

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=436, Percent_Identity=32.7981651376147, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1787518, Length=366, Percent_Identity=36.8852459016393, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786809, Length=266, Percent_Identity=27.4436090225564, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87082077, Length=265, Percent_Identity=26.7924528301887, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=442, Percent_Identity=40.7239819004525, Blast_Score=328, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6324361, Length=399, Percent_Identity=25.5639097744361, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53660; Mature: 53660

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTKEEFIKQKRERTTFLVITEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYL
CCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
GCNPYGEVKSVGTEVERTIYGRSEKLQSNVLQVLEEVIASAQVESPFPFCGGAVGYIGYD
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
VIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQKLSFVYVCRQDDSADYEEVYERL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHH
RVYKEEVIQGEEAEVNAIQSPLSFTSSITEKEFCEMVEMAKEYIRAGDIFQVVLSQRLQS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
ECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRG
HHCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCC
KTKREDEEIAKELLGNEKERAEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHI
CCCCCHHHHHHHHHCCCHHHHHHEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
VSEVYGTLQKQMGGFDALAYCLPAGTVSGAPKIRAMEIINELENEKRNVYAGAVGYVSFS
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEEEEC
GNLDMALAIRTMVVKDEKAYVQAGAGVVYDSDPVAEYEETLNKARALLEVMK
CCCCHHHHHHHHHHCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MMTKEEFIKQKRERTTFLVITEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYL
CCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
GCNPYGEVKSVGTEVERTIYGRSEKLQSNVLQVLEEVIASAQVESPFPFCGGAVGYIGYD
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
VIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQKLSFVYVCRQDDSADYEEVYERL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHH
RVYKEEVIQGEEAEVNAIQSPLSFTSSITEKEFCEMVEMAKEYIRAGDIFQVVLSQRLQS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
ECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRG
HHCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCC
KTKREDEEIAKELLGNEKERAEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHI
CCCCCHHHHHHHHHCCCHHHHHHEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
VSEVYGTLQKQMGGFDALAYCLPAGTVSGAPKIRAMEIINELENEKRNVYAGAVGYVSFS
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEEEEC
GNLDMALAIRTMVVKDEKAYVQAGAGVVYDSDPVAEYEETLNKARALLEVMK
CCCCHHHHHHHHHHCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]