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The map label for this gene is yngF [H]

Identifier: 218235464

GI number: 218235464

Start: 2221514

End: 2222569

Strand: Reverse

Name: yngF [H]

Synonym: BCB4264_A2322

Alternate gene names: 218235464

Gene position: 2222569-2221514 (Counterclockwise)

Preceding gene: 218231057

Following gene: 218235872

Centisome position: 41.01

GC content: 35.32

Gene sequence:

>1056_bases
ATGACTGAACAAGTTTTATTTTCTGTTAGTGAAAACAGCGTTGCGACAATTACTTTAAACCGTCCAAAAGCACTTAATTC
TTTATCTTATGACATGTTACAACCTATCGGACAAAAACTTAAAGAGTGGGAACACGATGAGCGTATTGCACTTATCGTGT
TAAAAGGAGCTGGCACAAAAGGTTTTTGTGCAGGCGGCGACATTAAAACTCTTTATGAAGCGCGTTCCAATGAAGTGGCA
TTGCAACATGCAGAACGTTTTTTTGAAGAAGAGTATGAAATTGATACATATATTTATCAATATACAAAACCGATTATTGC
TTGTTTAGATGGAATTGTAATGGGCGGTGGTGTCGGTCTTACAAATGGTGCGAAGTATCGCATTGTAACTGAGCGTACGA
AATGGGCAATGCCAGAGATGAATATCGGCTTCTTCCCAGACGTCGGAGCTGCATATTTCTTAAATAAAGCGCCTGGATAT
ACAGGACGATTCGTTGCTTTAACAGCATCTATTTTAAAAGCTTCTGACGTATTATTTATTAATGCTGCTGATTACTTTAT
GACATCTGATTCATTACCAGAGTTTCTTACTGAACTTGAAAGTGTAAATTGGCATAAAGAAGATGATGTACATACTAATT
TAAAAGAAGTTATTCGTACATTTGCAACTGCTCCAAACTTAGAAAGCGAGCTTGCTCCTTCATTAGAAGTAATCAATTCA
CATTTTGCTTTCGATACAATTGAAGAAATCATCCATTCATTGGAGAAAGATGAAAGTTCCTTTGCTCTAAAAACGAAAGA
AACACTGTTATCAAAATCCCCTATTTCACTAAAAGTAACATTAAAACAGTTTATTGATGGAAAAGATAAATCCGTTGAAG
AATGTTTCGCTACGGACCTTATACTTGCTAAAAATTTCATGAGACATGAAGATTTCTTCGAGGGAGTACGCTCCGTTGTC
GTTGATAAAGATCAAAATCCGAATTATAAATATAAACAGTTAAGTGACGTTTCAGAAGAAGATGTGAATCGTTTCTTTAA
CTTACTTAATGCATAA

Upstream 100 bases:

>100_bases
CAAATTAATATTTACCGTCAACTTTTGACAAAATTTATAAAGGACATTTCAGTACATATCAAGAATTAAGAATAAGAAGA
TATGTAAGGGAGGATGCATT

Downstream 100 bases:

>100_bases
AATGAAATTGTCATGAGGGGAGGTTTTGTTCATCCCCCACCTAACTTCTTTTCTTCAGCTAAATCTTGTGCGGTGAAAAT
CTTACTACCCGCAAATAGCG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: trans-2-enoyl-CoA; trans-3-enoyl-CoA; H2O

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTEQVLFSVSENSVATITLNRPKALNSLSYDMLQPIGQKLKEWEHDERIALIVLKGAGTKGFCAGGDIKTLYEARSNEVA
LQHAERFFEEEYEIDTYIYQYTKPIIACLDGIVMGGGVGLTNGAKYRIVTERTKWAMPEMNIGFFPDVGAAYFLNKAPGY
TGRFVALTASILKASDVLFINAADYFMTSDSLPEFLTELESVNWHKEDDVHTNLKEVIRTFATAPNLESELAPSLEVINS
HFAFDTIEEIIHSLEKDESSFALKTKETLLSKSPISLKVTLKQFIDGKDKSVEECFATDLILAKNFMRHEDFFEGVRSVV
VDKDQNPNYKYKQLSDVSEEDVNRFFNLLNA

Sequences:

>Translated_351_residues
MTEQVLFSVSENSVATITLNRPKALNSLSYDMLQPIGQKLKEWEHDERIALIVLKGAGTKGFCAGGDIKTLYEARSNEVA
LQHAERFFEEEYEIDTYIYQYTKPIIACLDGIVMGGGVGLTNGAKYRIVTERTKWAMPEMNIGFFPDVGAAYFLNKAPGY
TGRFVALTASILKASDVLFINAADYFMTSDSLPEFLTELESVNWHKEDDVHTNLKEVIRTFATAPNLESELAPSLEVINS
HFAFDTIEEIIHSLEKDESSFALKTKETLLSKSPISLKVTLKQFIDGKDKSVEECFATDLILAKNFMRHEDFFEGVRSVV
VDKDQNPNYKYKQLSDVSEEDVNRFFNLLNA
>Mature_350_residues
TEQVLFSVSENSVATITLNRPKALNSLSYDMLQPIGQKLKEWEHDERIALIVLKGAGTKGFCAGGDIKTLYEARSNEVAL
QHAERFFEEEYEIDTYIYQYTKPIIACLDGIVMGGGVGLTNGAKYRIVTERTKWAMPEMNIGFFPDVGAAYFLNKAPGYT
GRFVALTASILKASDVLFINAADYFMTSDSLPEFLTELESVNWHKEDDVHTNLKEVIRTFATAPNLESELAPSLEVINSH
FAFDTIEEIIHSLEKDESSFALKTKETLLSKSPISLKVTLKQFIDGKDKSVEECFATDLILAKNFMRHEDFFEGVRSVVV
DKDQNPNYKYKQLSDVSEEDVNRFFNLLNA

Specific function: Converts O-Succinylbenzoyl-CoA (Osb-CoA) To 1,4- Dihydroxy-2-Naphthoic Acid (Dhna). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=353, Percent_Identity=39.943342776204, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI37594469, Length=309, Percent_Identity=38.5113268608414, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI194097323, Length=150, Percent_Identity=34, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI68989263, Length=219, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI221142681, Length=216, Percent_Identity=26.3888888888889, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788597, Length=258, Percent_Identity=23.2558139534884, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787660, Length=174, Percent_Identity=31.6091954022989, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082183, Length=231, Percent_Identity=23.3766233766234, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=344, Percent_Identity=37.5, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI25144157, Length=344, Percent_Identity=37.5, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17554946, Length=151, Percent_Identity=31.7880794701987, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=157, Percent_Identity=34.3949044585987, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=187, Percent_Identity=21.9251336898396, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=160, Percent_Identity=27.5, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=350, Percent_Identity=32.2857142857143, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28571729, Length=348, Percent_Identity=40.2298850574713, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI28571730, Length=348, Percent_Identity=40.2298850574713, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI20129971, Length=214, Percent_Identity=28.5046728971963, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24653477, Length=214, Percent_Identity=28.5046728971963, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24653139, Length=147, Percent_Identity=27.2108843537415, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.17

Molecular weight: Translated: 39585; Mature: 39454

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQVLFSVSENSVATITLNRPKALNSLSYDMLQPIGQKLKEWEHDERIALIVLKGAGTK
CCCCEEEEECCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
GFCAGGDIKTLYEARSNEVALQHAERFFEEEYEIDTYIYQYTKPIIACLDGIVMGGGVGL
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TNGAKYRIVTERTKWAMPEMNIGFFPDVGAAYFLNKAPGYTGRFVALTASILKASDVLFI
CCCCEEEEEECCCHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEE
NAADYFMTSDSLPEFLTELESVNWHKEDDVHTNLKEVIRTFATAPNLESELAPSLEVINS
ECHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHH
HFAFDTIEEIIHSLEKDESSFALKTKETLLSKSPISLKVTLKQFIDGKDKSVEECFATDL
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCEEEEEHHHHCCCCCCCHHHHHHHHH
ILAKNFMRHEDFFEGVRSVVVDKDQNPNYKYKQLSDVSEEDVNRFFNLLNA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TEQVLFSVSENSVATITLNRPKALNSLSYDMLQPIGQKLKEWEHDERIALIVLKGAGTK
CCCEEEEECCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
GFCAGGDIKTLYEARSNEVALQHAERFFEEEYEIDTYIYQYTKPIIACLDGIVMGGGVGL
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TNGAKYRIVTERTKWAMPEMNIGFFPDVGAAYFLNKAPGYTGRFVALTASILKASDVLFI
CCCCEEEEEECCCHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEE
NAADYFMTSDSLPEFLTELESVNWHKEDDVHTNLKEVIRTFATAPNLESELAPSLEVINS
ECHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHH
HFAFDTIEEIIHSLEKDESSFALKTKETLLSKSPISLKVTLKQFIDGKDKSVEECFATDL
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCEEEEEHHHHCCCCCCCHHHHHHHHH
ILAKNFMRHEDFFEGVRSVVVDKDQNPNYKYKQLSDVSEEDVNRFFNLLNA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3S)-3-hydroxyacyl-CoA

Specific reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]