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The map label for this gene is hutH

Identifier: 218234768

GI number: 218234768

Start: 3675478

End: 3676998

Strand: Reverse

Name: hutH

Synonym: BCB4264_A3760

Alternate gene names: 218234768

Gene position: 3676998-3675478 (Counterclockwise)

Preceding gene: 218233986

Following gene: 218231468

Centisome position: 67.85

GC content: 40.11

Gene sequence:

>1521_bases
ATGATGATTACGTTAACAGGACATACATTGACAGTTGAAGAAATGAAGAGGTTATTACTGGAAGGAGAAGGTGTAACAGC
TTGTCCAACTAGTATGCAAAAGGTAGCGGAGTGCCGTGAAGTAGTTGAGAAAATTGTAGAGGACGGAAAAGTCGTTTACG
GTATTACAACTGGATTTGGAAAGTTTAGTGATGTGCTTATCCAAAAAGATGATGTAAAGGCACTTCAACATAATTTAATT
CAGTCACATGCATGTGGAATTGGTGATCCATTCCCGGAAGAAGTATCGCGCGGAATGTTAATTTTACGAGCGAACACGAT
GCTTAAAGGAGTATCAGGCGTAAGGCCGCTCGTTGTAAATATGCTTCTTGAGTTTGTAAATCGTAAAATTCATCCAGTCG
TTCCGCAACAAGGTTCACTTGGTGCAAGTGGAGATTTAGCACCTTTATCTCATCTTGCGCTCGTATTATTAGGCGAAGGT
GAAGTGTTCTATAAAGGGAAACGCGTTCATGCAATGGTTGCTCTTACAGAAGAAGGGCTTGAGCCAATTGAACTTGAAGC
GAAAGAAGGTCTTGCGTTAATTAATGGTACGCAGGCGATGACAGCACAAGGAGTTCTTTCTTATATAGAAGCAGAAGCAA
CGGCGTATCAAGCTGAACTAATTGCTTCGATGACAATTGAAGGGTTACAAGGCATTATTGATGCATTTGATGAAAATGTT
CATAAAGCACGTGGTTATAAAGAGCAAGTGGATGTAGCAAGCAGAATTCGTGACATTCTTCATGATAGTAAGTTAACAAC
AAAACAAGGAGAACTACGTGTACAGGATGCCTATTCACTTCGTTGTATCCCGCAAGTACACGGTGCTTCTTGGCAAGTTT
TGAATTATGTGAAAGAAAAATTAGAAATTGAAATGAATGCCGCAACAGATAATCCGCTAATCTTTGATGGCGGGGAAAAA
GTAATTTCAGGTGGTAATTTCCATGGTCAACCGATTGCGTTTGCGATGGACTTCTTAAAAGTAGGAATGGCGGAACTTGC
AAACATTTCAGAGCGTCGTATTGAGCGTTTAGTAAATCCGCAGTTAAACGATTTACCACCATTTTTAAGTCCAGAACCAG
GACTTCAGTCTGGTGCAATGATTATGCAATATGCTGCAGCGTCGCTAGTTTCTGAAAATAAAACGTTAGCACATCCGGCG
AGTGTTGATTCAATCCCGTCATCAGCTAACCAAGAAGATCACGTAAGTATGGGAACAATCGCTTCACGTCATGCACATCA
AATTATTCAAAATGTAAGACGTGTTCTTTCAATTGAAATGATTTGTGCGATGCAAGCGGCAGAATATCGCGGAATTGAAA
ACATGAGTACAGTGACGAAGAGCTTCTACCATCAAGGTCGTCAGCAGGTGCCATCTATTAAAAATGACCGTATATTCTCA
ACGGATATTGAAAATATTGCGCACTGGTTAAAAACGAATTATTCAATAAAAGAAAGATTAGACGTAAACGCAGCACTATA
A

Upstream 100 bases:

>100_bases
TTTGCCCATAGTCTATTAGTTAGAAGGGGGCCTTACTTTTTTAGGACAGAAGTCTGTCTTAAAAAGATAAGGTCCCCTTT
TGCCTTTTTAAGGAGGAAAA

Downstream 100 bases:

>100_bases
AATGAGAAAAGGGAGAGATTGAAATGGAAAAAGTACAACAAACAATTCGCGCGCCAAGAGGTACAGAGTTACAAACGAAA
GGGTGGGTGCAAGAAGCTGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MMITLTGHTLTVEEMKRLLLEGEGVTACPTSMQKVAECREVVEKIVEDGKVVYGITTGFGKFSDVLIQKDDVKALQHNLI
QSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNMLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEG
EVFYKGKRVHAMVALTEEGLEPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAELIASMTIEGLQGIIDAFDENV
HKARGYKEQVDVASRIRDILHDSKLTTKQGELRVQDAYSLRCIPQVHGASWQVLNYVKEKLEIEMNAATDNPLIFDGGEK
VISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPA
SVDSIPSSANQEDHVSMGTIASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSIKNDRIFS
TDIENIAHWLKTNYSIKERLDVNAAL

Sequences:

>Translated_506_residues
MMITLTGHTLTVEEMKRLLLEGEGVTACPTSMQKVAECREVVEKIVEDGKVVYGITTGFGKFSDVLIQKDDVKALQHNLI
QSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNMLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEG
EVFYKGKRVHAMVALTEEGLEPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAELIASMTIEGLQGIIDAFDENV
HKARGYKEQVDVASRIRDILHDSKLTTKQGELRVQDAYSLRCIPQVHGASWQVLNYVKEKLEIEMNAATDNPLIFDGGEK
VISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPA
SVDSIPSSANQEDHVSMGTIASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSIKNDRIFS
TDIENIAHWLKTNYSIKERLDVNAAL
>Mature_506_residues
MMITLTGHTLTVEEMKRLLLEGEGVTACPTSMQKVAECREVVEKIVEDGKVVYGITTGFGKFSDVLIQKDDVKALQHNLI
QSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNMLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEG
EVFYKGKRVHAMVALTEEGLEPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAELIASMTIEGLQGIIDAFDENV
HKARGYKEQVDVASRIRDILHDSKLTTKQGELRVQDAYSLRCIPQVHGASWQVLNYVKEKLEIEMNAATDNPLIFDGGEK
VISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPA
SVDSIPSSANQEDHVSMGTIASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSIKNDRIFS
TDIENIAHWLKTNYSIKERLDVNAAL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=45.0819672131148, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=501, Percent_Identity=43.5129740518962, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_BACC4 (B7HCD0)

Other databases:

- EMBL:   CP001176
- RefSeq:   YP_002368464.1
- EnsemblBacteria:   EBBACT00000110678
- GeneID:   7099837
- GenomeReviews:   CP001176_GR
- KEGG:   bcb:BCB4264_A3760
- GeneTree:   EBGT00050000001273
- HOGENOM:   HBG510887
- OMA:   HIEGDER
- ProtClustDB:   PRK09367
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 55501; Mature: 55501

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMITLTGHTLTVEEMKRLLLEGEGVTACPTSMQKVAECREVVEKIVEDGKVVYGITTGFG
CEEEEECCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
KFSDVLIQKDDVKALQHNLIQSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVN
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECHHHHCCCCHHHHHHH
MLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGEVFYKGKRVHAMVALTEEGL
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCCEEEECCEEEEEEEEHHCCC
EPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAELIASMTIEGLQGIIDAFDENV
CCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKARGYKEQVDVASRIRDILHDSKLTTKQGELRVQDAYSLRCIPQVHGASWQVLNYVKEK
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHH
LEIEMNAATDNPLIFDGGEKVISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNP
HEEEEECCCCCCEEEECCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
ASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSIKNDRIFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEH
TDIENIAHWLKTNYSIKERLDVNAAL
HHHHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure
MMITLTGHTLTVEEMKRLLLEGEGVTACPTSMQKVAECREVVEKIVEDGKVVYGITTGFG
CEEEEECCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
KFSDVLIQKDDVKALQHNLIQSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVN
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECHHHHCCCCHHHHHHH
MLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGEVFYKGKRVHAMVALTEEGL
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCCEEEECCEEEEEEEEHHCCC
EPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAELIASMTIEGLQGIIDAFDENV
CCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKARGYKEQVDVASRIRDILHDSKLTTKQGELRVQDAYSLRCIPQVHGASWQVLNYVKEK
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHH
LEIEMNAATDNPLIFDGGEKVISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNP
HEEEEECCCCCCEEEECCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
ASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSIKNDRIFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEH
TDIENIAHWLKTNYSIKERLDVNAAL
HHHHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA