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The map label for this gene is hutU [H]

Identifier: 218231468

GI number: 218231468

Start: 3673796

End: 3675454

Strand: Reverse

Name: hutU [H]

Synonym: BCB4264_A3759

Alternate gene names: 218231468

Gene position: 3675454-3673796 (Counterclockwise)

Preceding gene: 218234768

Following gene: 218236142

Centisome position: 67.82

GC content: 40.93

Gene sequence:

>1659_bases
ATGGAAAAAGTACAACAAACAATTCGCGCGCCAAGAGGTACAGAGTTACAAACGAAAGGGTGGGTGCAAGAAGCTGCACT
TCGTATGTTAATGAACAATTTAGATCCGGAAGTTGCTGAAAAACCAGAAGAATTAGTTGTGTATGGCGGAATTGGCCGTG
CAGCTCGTAACTGGGAAAGCTATCAGGCGATTGTAGATTCATTAAAAACGTTAGAAAGCGATGAAACGTTACTTGTTCAA
TCAGGAAAACCAGTTGCTATTTTTAAATCACATGAAGATGCACCTCGCGTTCTGTTAGCGAACTCAAACTTAGTACCAAA
ATGGGCAAACTGGGATCACTTCCGAGAACTAGAGAAAAAAGGTCTTATGATGTACGGACAAATGACAGCTGGTAGCTGGA
TTTACATTGGAACACAAGGGATTCTACAAGGAACATATGAAACATTTGGTGAAGCAGCTCGTCAACATTTCGACGGTTCA
TTAAAAGGTACATTAACACTTACTGCTGGTTTAGGTGGTATGGGTGGTGCACAACCTCTTGCTGTAACGATGAACGGCGG
TGTTGTCATTGCTATTGATGTTGATAAGCGTAGCATCGATCGTCGTATTGAAAAGAGATATTGTGACATGTATACAGAAT
CATTAGAAGAAGCATTAACTGTTGCGAACGAGTATAAAGAGAAGAAAGAACCAATTTCAATTGGCTTGCTAGGAAATGCG
GCAGAGATTTTACCAGAACTAGTGAAGCGTGATATTACGCCAGATTTAGTTACAGATCAAACATCTGCTCATGATCCATT
AAACGGTTATATTCCAGTAGGTTACACATTAGAAGAAGCAGCGAAACTTCGTGAAAAAGATCCAGAACGTTACGTACAAT
TATCAAAAGAAAGTATGACAAAACATGTGGAAGCGATGCTTGCGATGCAAGAAAAAGGTGCAATTACATTTGATTATGGA
AATAACATTCGCCAAGTTGCTTTCGATGAAGGTTTGAAAAATGCTTTCGATTTCCCAGGATTCGTTCCAGCATTTATTCG
TCCATTATTCTGTGAAGGAAAAGGGCCATTCCGCTGGGTAGCACTTTCTGGTGATCCAGAAGATATTTATAAAACAGACG
AAGTAATTTTACGTGAGTTCGCTGATAATGAACATTTATGTAACTGGATTCGTATGGCACGTCAACAAGTTGAGTTCCAA
GGACTTCCATCACGTATTTGTTGGTTAGGTTACGGTGAGCGTGCGAAATTTGGTCGTATCATTAATGAAATGGTTGCAAA
TGGTGAATTATCAGCACCGATTGTTATTGGTCGTGACCATTTAGATTGCGGATCAGTAGCATCTCCAAACCGTGAAACAG
AAGCGATGAAAGACGGTAGTGATGCAGTAGCAGACTGGCCAATTTTAAATGCATTAATTAATAGTGTAAACGGTGCAAGC
TGGGTATCTGTTCACCACGGTGGTGGCGTTGGTATGGGGTATTCACTTCATGCGGGAATGGTTATCGTTGCAGATGGAAC
AGAAGCAGCAGCAAAACGAATTGAGCGCGTATTAACTTCTGATCCTGGTATGGGTGTTGTTCGTCACGTGGATGCAGGGT
ATGACTTAGCTGTGGAAACTGCGAAAGAAAAAGGCGTTAACATTCCGATGATGAAATAA

Upstream 100 bases:

>100_bases
ATATTGAAAATATTGCGCACTGGTTAAAAACGAATTATTCAATAAAAGAAAGATTAGACGTAAACGCAGCACTATAAAAT
GAGAAAAGGGAGAGATTGAA

Downstream 100 bases:

>100_bases
GGAGGAGAAAACATGCTGGACACTTTACTAATAAATATCGGTCAATTACTAACAATGGATCAAGAAGATGGCTTGTTAAG
ACGGGAAGCGATGAACACGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFDGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
AEILPELVKRDITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREKDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Sequences:

>Translated_552_residues
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFDGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
AEILPELVKRDITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREKDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK
>Mature_552_residues
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFDGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
AEILPELVKRDITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREKDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=563, Percent_Identity=35.1687388987567, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI260306182, Length=623, Percent_Identity=32.4237560192616, Blast_Score=298, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71997891, Length=551, Percent_Identity=35.5716878402904, Blast_Score=340, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60851; Mature: 60851

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YQAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFDGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRDITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREKDPERYVQLSKESMT
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC
>Mature Secondary Structure
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YQAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFDGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRDITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREKDPERYVQLSKESMT
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA