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The map label for this gene is comEC [H]

Identifier: 218234707

GI number: 218234707

Start: 4071184

End: 4072086

Strand: Reverse

Name: comEC [H]

Synonym: BCB4264_A4165

Alternate gene names: 218234707

Gene position: 4072086-4071184 (Counterclockwise)

Preceding gene: 218233038

Following gene: 218233265

Centisome position: 75.14

GC content: 35.11

Gene sequence:

>903_bases
ATGAGAGGTATGCGGATTATTTTATTATTAGTTTCTGTTTTATTATGTTTTTCTTTAAATAGCGCATCAGCTAAAAGGTA
TATGATGTCCATTCATACTACGTCTCCTTTACATATGCATCGGCAACATCTTAGTAAAATGAAAGTGAGCTTTTTAAAAG
TGGGGCAAGGTGACGCAACACTTATTATAATGCCAAATGGACAAACAATGTTAATTGATGGAGGACCTTATGAAGCAGGA
GAGGTTATTATTCAGAAATTAATTGAGAAAGGGATTAATCATTTAGATGTAATTGTCAGTACGCATCCCGATATGGATCA
TATAGGGGGGTTAATTCCAATTGTAGAGCAAATGCCGGTATCGCTTATATTAGATAGCGGAAAAACATATAGTTCTCTTA
CTTATCATACGTATCGGAATAATATAAAAAAAAGAGGGATACCTTTCGTTTCAGTAAAGGAAGGACAATATATACCGCTG
GATCCACATGTTTCTATACAAGTATTAAACAACGGGAAATCAAAAGATGAAAATAATGAATCCTCAATTGTTTTAAAGGT
GCGATATGGAAAAGCGGATTTTTTATTAATGGGTGACGCGGATGTACGGACAGAACATGAAATATTAAAACAATTTGATG
TCCATGCAGATGTGTTAAAAGTGGGGCATCACGGCTCATATACTTCAACAAGTGAAACGTTTATAAAAAAAGTGGAACCG
CAGTTTGCTATTTTGTCGTACGGGAGTAGTAATCCGTATGGACATCCTCACCAAAGTGTAGTGAAACGCTTAAAAAGGCA
CGGTATAATGGTATATAGAACGAATAAAAGTACAGTAGAAATGGAAACAGATGGTGAACATATTATGTTAGAGTCTAGCG
GGTTAATGCCATTATTGAAGTGA

Upstream 100 bases:

>100_bases
CTTACAAGAGATATCGAAATAAAAGCTTAGCATTTTGCTAAGCTTTTTTTGTATATCAATTATTTACAGTGCCATACTAA
ATGAAAAAAGGAGACGAGTT

Downstream 100 bases:

>100_bases
TTTCTATATTAGGGGGCGATACTGTCCCTTTTTGGAAAAATGAATAATATATATTATAATTATAAGAGACGTAAGAAATT
TCCTTTTCTGTTGAATAAAA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MRGMRIILLLVSVLLCFSLNSASAKRYMMSIHTTSPLHMHRQHLSKMKVSFLKVGQGDATLIIMPNGQTMLIDGGPYEAG
EVIIQKLIEKGINHLDVIVSTHPDMDHIGGLIPIVEQMPVSLILDSGKTYSSLTYHTYRNNIKKRGIPFVSVKEGQYIPL
DPHVSIQVLNNGKSKDENNESSIVLKVRYGKADFLLMGDADVRTEHEILKQFDVHADVLKVGHHGSYTSTSETFIKKVEP
QFAILSYGSSNPYGHPHQSVVKRLKRHGIMVYRTNKSTVEMETDGEHIMLESSGLMPLLK

Sequences:

>Translated_300_residues
MRGMRIILLLVSVLLCFSLNSASAKRYMMSIHTTSPLHMHRQHLSKMKVSFLKVGQGDATLIIMPNGQTMLIDGGPYEAG
EVIIQKLIEKGINHLDVIVSTHPDMDHIGGLIPIVEQMPVSLILDSGKTYSSLTYHTYRNNIKKRGIPFVSVKEGQYIPL
DPHVSIQVLNNGKSKDENNESSIVLKVRYGKADFLLMGDADVRTEHEILKQFDVHADVLKVGHHGSYTSTSETFIKKVEP
QFAILSYGSSNPYGHPHQSVVKRLKRHGIMVYRTNKSTVEMETDGEHIMLESSGLMPLLK
>Mature_300_residues
MRGMRIILLLVSVLLCFSLNSASAKRYMMSIHTTSPLHMHRQHLSKMKVSFLKVGQGDATLIIMPNGQTMLIDGGPYEAG
EVIIQKLIEKGINHLDVIVSTHPDMDHIGGLIPIVEQMPVSLILDSGKTYSSLTYHTYRNNIKKRGIPFVSVKEGQYIPL
DPHVSIQVLNNGKSKDENNESSIVLKVRYGKADFLLMGDADVRTEHEILKQFDVHADVLKVGHHGSYTSTSETFIKKVEP
QFAILSYGSSNPYGHPHQSVVKRLKRHGIMVYRTNKSTVEMETDGEHIMLESSGLMPLLK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=253, Percent_Identity=28.0632411067194, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 33570; Mature: 33570

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGMRIILLLVSVLLCFSLNSASAKRYMMSIHTTSPLHMHRQHLSKMKVSFLKVGQGDAT
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEECCCCEE
LIIMPNGQTMLIDGGPYEAGEVIIQKLIEKGINHLDVIVSTHPDMDHIGGLIPIVEQMPV
EEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCHHHHHHHCCE
SLILDSGKTYSSLTYHTYRNNIKKRGIPFVSVKEGQYIPLDPHVSIQVLNNGKSKDENNE
EEEEECCCCCCCEEEHHHHHCHHHCCCCEEEECCCCEEECCCCEEEEEEECCCCCCCCCC
SSIVLKVRYGKADFLLMGDADVRTEHEILKQFDVHADVLKVGHHGSYTSTSETFIKKVEP
CEEEEEEEECCEEEEEECCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHCCC
QFAILSYGSSNPYGHPHQSVVKRLKRHGIMVYRTNKSTVEMETDGEHIMLESSGLMPLLK
CEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCCEEEEECCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MRGMRIILLLVSVLLCFSLNSASAKRYMMSIHTTSPLHMHRQHLSKMKVSFLKVGQGDAT
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEECCCCEE
LIIMPNGQTMLIDGGPYEAGEVIIQKLIEKGINHLDVIVSTHPDMDHIGGLIPIVEQMPV
EEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCHHHHHHHCCE
SLILDSGKTYSSLTYHTYRNNIKKRGIPFVSVKEGQYIPLDPHVSIQVLNNGKSKDENNE
EEEEECCCCCCCEEEHHHHHCHHHCCCCEEEECCCCEEECCCCEEEEEEECCCCCCCCCC
SSIVLKVRYGKADFLLMGDADVRTEHEILKQFDVHADVLKVGHHGSYTSTSETFIKKVEP
CEEEEEEEECCEEEEEECCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHCCC
QFAILSYGSSNPYGHPHQSVVKRLKRHGIMVYRTNKSTVEMETDGEHIMLESSGLMPLLK
CEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCCEEEEECCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]