Click here to switch to the map view.

The map label for this gene is sirC [H]

Identifier: 218234578

GI number: 218234578

Start: 1420166

End: 1420780

Strand: Direct

Name: sirC [H]

Synonym: BCB4264_A1483

Alternate gene names: 218234578

Gene position: 1420166-1420780 (Clockwise)

Preceding gene: 218230762

Following gene: 218231579

Centisome position: 26.21

GC content: 33.98

Gene sequence:

>615_bases
ATGTATCCACTTACAGTGCGAGTTAATGAGAAACGCGTTGTTGTTATTGGCGGGGGAAAAGTTGCAGGATTTAAAATTAT
TCCTTTACTCAAACAGGGTGCGGATATAGTTGTGATAAGTCCAGAATTAGATGCGAATTTAGTAAAACTTGTGGAAGAAA
AGAAAATTCGTTGGTATCAAAGAGAATATGAAAAAAGTGATATTAAAAGTGCTTTTTTAGTTGTTGCAGCGAGTAGTGAT
TCAATATTAAATGAACAAGTTGCTGAAGATGCCGCTGAGAATCAATTAGTAAATGTTATTACAAATCCGGAAAGTGGTAA
TGTTCATTTTCCGGCAGCGATTCATCGTGGTTTACTTAATATAGCAGTTTCTACTGGGGGAGCGAGCCCGAAGCTCGCAA
AAAAAATTCGAGATGATATTGCAAATAAATATGATGAGACATATGAATCGTATTTAGATTTTTTATATGAAGTAAGGTTG
AAGTTAAAAGATTTACAGTTAGAAAAGAGGGAACGAAATATATTGCTCCAAGAAGTGTTGAAATCAGTATATGTGCAAAA
TGAGGGGAAAAGAGAAAGTTTTTTACGTGAGTTAGAGGAAAAGGTTTTAAAATAA

Upstream 100 bases:

>100_bases
GAAGTGGAAGAGATAAAAATCAGTCCATATTTAGGGAAGAATGAAGCGTTTCAAGATATGTTAATTCAGAAAACGACGGA
GTTATTGAAAGGAGATCAGT

Downstream 100 bases:

>100_bases
TAAAAGATAAAGTGCGCTTTACAAATATAAAAATATAATTTATAATCACAAGTAACTTCAATAGATGAAATCGATGAGCA
AGAAGAGTACGTATATTTGA

Product: precorrin-2 dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MYPLTVRVNEKRVVVIGGGKVAGFKIIPLLKQGADIVVISPELDANLVKLVEEKKIRWYQREYEKSDIKSAFLVVAASSD
SILNEQVAEDAAENQLVNVITNPESGNVHFPAAIHRGLLNIAVSTGGASPKLAKKIRDDIANKYDETYESYLDFLYEVRL
KLKDLQLEKRERNILLQEVLKSVYVQNEGKRESFLRELEEKVLK

Sequences:

>Translated_204_residues
MYPLTVRVNEKRVVVIGGGKVAGFKIIPLLKQGADIVVISPELDANLVKLVEEKKIRWYQREYEKSDIKSAFLVVAASSD
SILNEQVAEDAAENQLVNVITNPESGNVHFPAAIHRGLLNIAVSTGGASPKLAKKIRDDIANKYDETYESYLDFLYEVRL
KLKDLQLEKRERNILLQEVLKSVYVQNEGKRESFLRELEEKVLK
>Mature_204_residues
MYPLTVRVNEKRVVVIGGGKVAGFKIIPLLKQGADIVVISPELDANLVKLVEEKKIRWYQREYEKSDIKSAFLVVAASSD
SILNEQVAEDAAENQLVNVITNPESGNVHFPAAIHRGLLNIAVSTGGASPKLAKKIRDDIANKYDETYESYLDFLYEVRL
KLKDLQLEKRERNILLQEVLKSVYVQNEGKRESFLRELEEKVLK

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=147, Percent_Identity=31.2925170068027, Blast_Score=71, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 23097; Mature: 23097

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLTVRVNEKRVVVIGGGKVAGFKIIPLLKQGADIVVISPELDANLVKLVEEKKIRWYQ
CCCEEEEECCCEEEEEECCEECCEEEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
REYEKSDIKSAFLVVAASSDSILNEQVAEDAAENQLVNVITNPESGNVHFPAAIHRGLLN
HHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEHHHHHHHHHH
IAVSTGGASPKLAKKIRDDIANKYDETYESYLDFLYEVRLKLKDLQLEKRERNILLQEVL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSVYVQNEGKRESFLRELEEKVLK
HHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYPLTVRVNEKRVVVIGGGKVAGFKIIPLLKQGADIVVISPELDANLVKLVEEKKIRWYQ
CCCEEEEECCCEEEEEECCEECCEEEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
REYEKSDIKSAFLVVAASSDSILNEQVAEDAAENQLVNVITNPESGNVHFPAAIHRGLLN
HHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEHHHHHHHHHH
IAVSTGGASPKLAKKIRDDIANKYDETYESYLDFLYEVRLKLKDLQLEKRERNILLQEVL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSVYVQNEGKRESFLRELEEKVLK
HHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA