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The map label for this gene is gltT [H]

Identifier: 218234135

GI number: 218234135

Start: 1424610

End: 1425884

Strand: Direct

Name: gltT [H]

Synonym: BCB4264_A1487

Alternate gene names: 218234135

Gene position: 1424610-1425884 (Clockwise)

Preceding gene: 218231579

Following gene: 218233540

Centisome position: 26.29

GC content: 36.24

Gene sequence:

>1275_bases
ATGAAAAGAATAGGACTTGCATGGCAAATATTAATAGGACTTGCGCTTGGTATTGCGGTTGGTGCGATTTTCTTTGATAA
TCCAGCTGTTGTGAAGTACTTACAACCAATTGGTGATATTTTCATCCGATTAATTAAAATGATCGTTGTACCGATTGTTG
TAGCAAGTATTGTTGTTGGGGTTGCTGGTGTTGGCGATGTTAAAAAACTAGGTCGACTAGGCGGAAAAACAATTCTTTAC
TTTGAAATTATTACAACAATTGCAATTATTGTTGGTCTATTAATAGCGAATATTTTCCAACCAGGAAAAGGCGTAAATAT
GGAGCAGTTAACAAAGACAGATATTTCGAAATATACACATACGACAGAGCAAGTACAAAGTCATTCATTTGCAGATACAT
TTGTAAATATTGTTCCAACGAACATTATGAAGTCGTTAGCTGACGGAGATATGCTTGCTATTATCTTCTTCTCTGTACTA
TTTGGTTTAGGTGTAGCAGCGATTGGTGAAAGAGGAAGACCAGTTCTTCAATTTTTCCAAGGTGTAGCTGATGCAATGTT
TTACGTAACAAACCAAGTTATGAAATTTGCACCATTTGGTGTGTTTGCACTAATTGGTGTTACAGTTTCTACATTTGGTC
TTGCTTCATTAATTCCGTTAGGCAAATTACTAATTGTCGTATATGGAGCAATGATTTTCTTCGTCGTAGTTGTCTTAGGA
CTTACAGCGAAAATATTTGGAATTAACATTTTCCAATTCTTTAAGATTTTAAAAGACGAGCTGATCTTAGCGTATTCTAC
AGCAAGCTCAGAAACAGTTTTACCAAAAATCATGGAGAAAATGGAGAAATTCGGTTGCCCGAAAGCAATTACATCTTTCG
TTATTCCGACAGGTTATTCATTTAACTTAGATGGATCAACTTTATATCAAGCAATTGCGGCTATTTTCTTAGCGCAAATG
TACGGTATTGATTTATCTATTACACAACAAATTACATTGTTGCTTGTATTAATGGTTACATCAAAAGGTATCGCAGGTGT
ACCGGGCGTATCATTCGTTGTATTATTAGCGACACTTGGTACAGTAGGTATTCCACCTGAAGGCTTAGCGTTCATTGCTG
GTATTGACCGTATTTTAGATATGGCTCGTACAGCAGTTAACGTTGTAGGAAACTCTTTAGCAGCTGTAGTTATGTCTAAG
TGGGAAGGTCAATATGACGCTGAAAAAGGACAAGCTTATTTAAAAGAGATTTCTGAAAAGGGTCAAGCGGCTTAA

Upstream 100 bases:

>100_bases
TAGTGAATTGTCGAATAATATGTAATACTCTTAATTTCTTAGTTTTATAGAGATAGAATGAGAGATAGAGTGACACATCG
AAGAGGGGGTTACAACAAAT

Downstream 100 bases:

>100_bases
TTATAATATGAACAAGCTCTCACATAATATGTGGGAGCTTTTCTGTATATAGAAGAGGAGCAGACATAATGAAACGAAAA
TATGGTGACGGTTCTTCGTG

Product: proton/glutamate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKRIGLAWQILIGLALGIAVGAIFFDNPAVVKYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTILY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITQQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPPEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISEKGQAA

Sequences:

>Translated_424_residues
MKRIGLAWQILIGLALGIAVGAIFFDNPAVVKYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTILY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITQQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPPEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISEKGQAA
>Mature_424_residues
MKRIGLAWQILIGLALGIAVGAIFFDNPAVVKYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTILY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITQQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPPEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISEKGQAA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=425, Percent_Identity=27.5294117647059, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4827012, Length=454, Percent_Identity=28.1938325991189, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI40254478, Length=458, Percent_Identity=27.5109170305677, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI169790839, Length=452, Percent_Identity=28.3185840707965, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI194239697, Length=442, Percent_Identity=27.6018099547511, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI66773030, Length=447, Percent_Identity=27.7404921700224, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5032093, Length=401, Percent_Identity=25.4364089775561, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=26.8115942028986, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=26.8115942028986, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI301601644, Length=185, Percent_Identity=31.3513513513514, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790514, Length=430, Percent_Identity=62.3255813953488, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1789947, Length=418, Percent_Identity=39.4736842105263, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1788024, Length=413, Percent_Identity=27.3607748184019, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789473, Length=256, Percent_Identity=23.828125, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=29.2452830188679, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71996953, Length=464, Percent_Identity=27.3706896551724, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71983106, Length=436, Percent_Identity=26.1467889908257, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=436, Percent_Identity=26.1467889908257, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI193206505, Length=428, Percent_Identity=28.5046728971963, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=25.1243781094527, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=434, Percent_Identity=24.1935483870968, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24583025, Length=408, Percent_Identity=25.7352941176471, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17137668, Length=408, Percent_Identity=25.7352941176471, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24583023, Length=408, Percent_Identity=25.7352941176471, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281360481, Length=443, Percent_Identity=24.8306997742664, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360483, Length=443, Percent_Identity=24.8306997742664, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17137666, Length=443, Percent_Identity=24.8306997742664, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45399; Mature: 45399

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure
MKRIGLAWQILIGLALGIAVGAIFFDNPAVVKYLQPIGDIFIRLIKMIVVPIVVASIVVG
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGVGDVKKLGRLGGKTILYFEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTH
HCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVLFGLGVAAIGERGRPVLQFFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYS
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
FNLDGSTLYQAIAAIFLAQMYGIDLSITQQITLLLVLMVTSKGIAGVPGVSFVVLLATLG
ECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
TVGIPPEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDAEKGQAYLKEISEK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
GQAA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]